Comparison of the effects of aqueous extract of Sida cordifolia L. and 5-fluorouracil in colon carcinogenesis induced by 1,2- dimethylhydrazine on Wistar rats

• Autor(a) principal: Cruz, Filipe Jonas Federico da
• Data de Publicação: 2022
• Outros Autores: Souza, Daniel Ferreira Almeida de, Anjos, Samila Fernandes dos Santos, Barbosa, Ana Paula Fernandes, Marques, Juliana Pedrosa de Holanda, Barros, Svetlana Maria Wanderley de, Santana, Antonio Euzebio Goulart, Moreira, Magna Suzana Alexandre, Jucá, Mario Jorge, Filipe Jonas Federico da Cruz
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista Fitos
• Texto Completo: https://revistafitos.far.fiocruz.br/index.php/revista-fitos/article/view/1085
• topic: Colorectal cancer; Chemoprevention; da cordifolia L; Aberrant crypt; 1,2-dymethylhydrazine

Search for new therapeutic agents and alternative strategies for chemoprevention of colorectal cancer is needed to reduce morbidity and mortality resulting from this disease. This study aimed to compare the effect of aqueous extract of Sida cordifolia L. and 5- fluorouracil (5-FU) on colon carcinogenesis induced by 1,2- dimethylhydrazine (1,2-DMH). The extract reduced the frequency of aberrant crypts to regarding the positive control, but there was no significant difference among the positive control animals, those who received the extract and those receiving standard anticancer drug. Thus, the aqueous extract of Sida cordifolia L. 800 mg/kg showed no statistical impact on carcinogenesis in animal models, but showed a significant anti-inflammatory effect on the colon mucosa.