Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25574 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil. |
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Riccio, Lilian Rose PrattBianco Junior, CesareTotino, Paulo Renato RivasSilva, Daiana de Souza Perce daRiccio, Evelyn Kety PrattVidal, Vítor EnnesFerreira, Ana Gisele Costa NevesPerales, JonasRocha, Surza Lucia Gonçalves daSilva, Fabrício Dias daCruz, Maria de Fátima Ferreira daDaniel-Ribeiro, Cláudio TadeuFerreira, Joseli de OliveiraTheisen, MichaelCarvalho, Leonardo José de MouraBanic, Dalma MariaSilva, Luciene Aquino2018-04-03T12:06:24Z2018-04-03T12:06:24Z2011RICCIO, Lilian Rose Pratt; et al. Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth. Mem Inst Oswaldo Cruz, v. 106, Suppl. I, p. 34-43, 2011.0074-0276https://www.arca.fiocruz.br/handle/icict/255741678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzMaláriaPlasmodium falciparumanticorposinibição do crescimentoAtividade biológicaMalariaPlasmodium falciparumGLURPantibodiesbiological activitygrowth inhibitionAntibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growthinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Toxinologia. Rio de Janeiro, RJ. BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.Statens Seruminstitut. Copenhagen, Denmark.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil.The glutamate-rich protein (GLURP) is an exoantigen expressed in all stages of the Plasmodium falciparum life cycle in humans. Anti-GLURP antibodies can inhibit parasite growth in the presence of monocytes via antibody-dependent cellular inhibition (ADCI), and a major parasite-inhibitory region has been found in the N-terminal R0 region of the protein. Herein, we describe the antiplasmodial activity of anti-GLURP antibodies present in the sera from individuals naturally exposed to malaria in a Brazilian malaria-endemic area. The anti-R0 antibodies showed a potent inhibitory effect on the growth of P. falciparum in vitro, both in the presence (ADCI) and absence (GI) of monocytes. The inhibitory effect on parasite growth was comparable to the effect of IgGs purified from pooled sera from hyperimmune African individuals. Interestingly, in the ADCI test, higher levels of tumour necrosis factor alpha (TNF-α) were observed in the supernatant from cultures with higher parasitemias. Our data suggest that the antibody response induced by GLURP-R0 in naturally exposed individuals may have an important role in controlling parasitemia because these antibodies are able to inhibit the in vitro growth of P. falciparum with or without the cooperation from monocytes. Our results also indicate that TNF-α may not be relevant for the inhibitory effect on P. falciparum in vitro growth.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25574/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlilian_riccio_etal_IOC_2011.pdflilian_riccio_etal_IOC_2011.pdfapplication/pdf602888https://www.arca.fiocruz.br/bitstream/icict/25574/2/lilian_riccio_etal_IOC_2011.pdf551b486f7c055e1dc0794693cb8d8a62MD52TEXTlilian_riccio_etal_IOC_2011.pdf.txtlilian_riccio_etal_IOC_2011.pdf.txtExtracted texttext/plain54750https://www.arca.fiocruz.br/bitstream/icict/25574/3/lilian_riccio_etal_IOC_2011.pdf.txt54c1495e0cf7e51111764238ca2cb143MD53icict/255742020-07-17 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| dc.title.pt_BR.fl_str_mv |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| title |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| spellingShingle |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth Riccio, Lilian Rose Pratt Malária Plasmodium falciparum anticorpos inibição do crescimento Atividade biológica Malaria Plasmodium falciparum GLURP antibodies biological activity growth inhibition |
| title_short |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| title_full |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| title_fullStr |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| title_full_unstemmed |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| title_sort |
Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth |
| author |
Riccio, Lilian Rose Pratt |
| author_facet |
Riccio, Lilian Rose Pratt Bianco Junior, Cesare Totino, Paulo Renato Rivas Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Vidal, Vítor Ennes Ferreira, Ana Gisele Costa Neves Perales, Jonas Rocha, Surza Lucia Gonçalves da Silva, Fabrício Dias da Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli de Oliveira Theisen, Michael Carvalho, Leonardo José de Moura Banic, Dalma Maria Silva, Luciene Aquino |
| author_role |
author |
| author2 |
Bianco Junior, Cesare Totino, Paulo Renato Rivas Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Vidal, Vítor Ennes Ferreira, Ana Gisele Costa Neves Perales, Jonas Rocha, Surza Lucia Gonçalves da Silva, Fabrício Dias da Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli de Oliveira Theisen, Michael Carvalho, Leonardo José de Moura Banic, Dalma Maria Silva, Luciene Aquino |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Riccio, Lilian Rose Pratt Bianco Junior, Cesare Totino, Paulo Renato Rivas Silva, Daiana de Souza Perce da Riccio, Evelyn Kety Pratt Vidal, Vítor Ennes Ferreira, Ana Gisele Costa Neves Perales, Jonas Rocha, Surza Lucia Gonçalves da Silva, Fabrício Dias da Cruz, Maria de Fátima Ferreira da Daniel-Ribeiro, Cláudio Tadeu Ferreira, Joseli de Oliveira Theisen, Michael Carvalho, Leonardo José de Moura Banic, Dalma Maria Silva, Luciene Aquino |
| dc.subject.other.pt_BR.fl_str_mv |
Malária Plasmodium falciparum anticorpos inibição do crescimento Atividade biológica |
| topic |
Malária Plasmodium falciparum anticorpos inibição do crescimento Atividade biológica Malaria Plasmodium falciparum GLURP antibodies biological activity growth inhibition |
| dc.subject.en.pt_BR.fl_str_mv |
Malaria Plasmodium falciparum GLURP antibodies biological activity growth inhibition |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ. Brasil. |
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2011 |
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2011 |
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2018-04-03T12:06:24Z |
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2018-04-03T12:06:24Z |
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info:eu-repo/semantics/article |
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RICCIO, Lilian Rose Pratt; et al. Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth. Mem Inst Oswaldo Cruz, v. 106, Suppl. I, p. 34-43, 2011. |
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https://www.arca.fiocruz.br/handle/icict/25574 |
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0074-0276 |
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1678-8060 |
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RICCIO, Lilian Rose Pratt; et al. Antibodies against the Plasmodium falciparum glutamate-rich protein from naturally exposed individuals living in a Brazilian malaria-endemic area can inhibit in vitro parasite growth. Mem Inst Oswaldo Cruz, v. 106, Suppl. I, p. 34-43, 2011. 0074-0276 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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