Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.

Detalhes bibliográficos
Autor(a) principal: Venkatasubramanian, Sambasivan
Data de Publicação: 2016
Outros Autores: Tripathi, Deepak, Tucker, Torry, Paidipally, Padmaja, Cheekatla, Satyanarayana, Welch, Elwyn, Raghunath, Anjana, Jeffers, Ann, Tvinnereim, Amy R, Schechter, Melissa E, Andrade, Bruno de Bezerril, Mackman, Nizel, Idell, Steven, Vankayalapati, Ramakrishna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13950
Resumo: University of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USA
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spelling Venkatasubramanian, SambasivanTripathi, DeepakTucker, TorryPaidipally, PadmajaCheekatla, SatyanarayanaWelch, ElwynRaghunath, AnjanaJeffers, AnnTvinnereim, Amy RSchechter, Melissa EAndrade, Bruno de BezerrilMackman, NizelIdell, StevenVankayalapati, Ramakrishna2016-04-20T19:03:54Z2016-04-20T19:03:54Z2016VENKATASUBRAMANIAN, S. et. al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. European Journal of Immunology, v. 46, p. 464–479, 2016.0014-2980https://www.arca.fiocruz.br/handle/icict/1395010.1002/eji.201545817engWiley-VCH VerlagTissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Cellular and Molecular Biology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Cellular and Molecular Biology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USAFrederick National Laboratory for Cancer Research. Clinical Research Directorate/Clinical Monitoring Research Program. Leidos Biomedical Research, Inc. Frederick, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Integrado de Microbiologia e Imunoregulação. Salvador, BA, Brasil / Brazilian Institute for Tuberculosis Research. Research Center. Salvador, BA, BrasilThe University of North Carolina at Chapel Hill School of Medicine. Department of Medicine. NC, USAUniversity of Texas Health Science Center at Tyler. Department of Cellular and Molecular Biology. Tyler, TX, USAUniversity of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USATissue factor (TF) is a transmembrane glycoprotein that plays an essential role in hemostasis by activating coagulation. TF is also expressed by monocytes/macrophages as part of the innate immune response to infections. In the current study, we determined the role of TF expressed by myeloid cells during Mycobacterium tuberculosis (M. tb) infection by using mice lacking the TF gene in myeloid cells (TF(Δ) ) and human monocyte derived macrophages (MDMs). We found that during M. tb infection, a deficiency of TF in myeloid cells was associated with reduced inducible nitric oxide synthase (iNOS) expression, enhanced arginase 1 (Arg1) expression, enhanced IL-10 production and reduced apoptosis in infected macrophages, which augmented M. tb growth. Our results demonstrate that a deficiency of TF in myeloid cells promotes M2-like phenotype in M .tb infected macrophages. A deficiency in TF expression by myeloid cells was also associated with reduced fibrin deposition and increased matrix metalloproteases (MMP)-2 and MMP-9 mediated inflammation in M. tb infected lungs. Our studies demonstrate that TF expressed by myeloid cells has newly recognized abilities to polarize macrophages and to regulate M. tb growthApoptosis IL-10MacrophageM. tuberculosisTissue factorinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13950/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVenkatasubramanian_Tissue factor....pdfVenkatasubramanian_Tissue factor....pdfapplication/pdf2078232https://www.arca.fiocruz.br/bitstream/icict/13950/2/Venkatasubramanian_Tissue%20factor....pdf64ac10f6fa8886788693ba980ff0c7eeMD52TEXTVenkatasubramanian_Tissue factor....pdf.txtVenkatasubramanian_Tissue factor....pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
title Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
spellingShingle Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
Venkatasubramanian, Sambasivan
Apoptosis IL-10
Macrophage
M. tuberculosis
Tissue factor
title_short Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
title_full Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
title_fullStr Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
title_full_unstemmed Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
title_sort Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection.
author Venkatasubramanian, Sambasivan
author_facet Venkatasubramanian, Sambasivan
Tripathi, Deepak
Tucker, Torry
Paidipally, Padmaja
Cheekatla, Satyanarayana
Welch, Elwyn
Raghunath, Anjana
Jeffers, Ann
Tvinnereim, Amy R
Schechter, Melissa E
Andrade, Bruno de Bezerril
Mackman, Nizel
Idell, Steven
Vankayalapati, Ramakrishna
author_role author
author2 Tripathi, Deepak
Tucker, Torry
Paidipally, Padmaja
Cheekatla, Satyanarayana
Welch, Elwyn
Raghunath, Anjana
Jeffers, Ann
Tvinnereim, Amy R
Schechter, Melissa E
Andrade, Bruno de Bezerril
Mackman, Nizel
Idell, Steven
Vankayalapati, Ramakrishna
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Venkatasubramanian, Sambasivan
Tripathi, Deepak
Tucker, Torry
Paidipally, Padmaja
Cheekatla, Satyanarayana
Welch, Elwyn
Raghunath, Anjana
Jeffers, Ann
Tvinnereim, Amy R
Schechter, Melissa E
Andrade, Bruno de Bezerril
Mackman, Nizel
Idell, Steven
Vankayalapati, Ramakrishna
dc.subject.en.pt_BR.fl_str_mv Apoptosis IL-10
Macrophage
M. tuberculosis
Tissue factor
topic Apoptosis IL-10
Macrophage
M. tuberculosis
Tissue factor
description University of Texas Health Science Center at Tyler. Department of Pulmonary Immunology. Tyler, TX, USA
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-04-20T19:03:54Z
dc.date.available.fl_str_mv 2016-04-20T19:03:54Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VENKATASUBRAMANIAN, S. et. al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. European Journal of Immunology, v. 46, p. 464–479, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13950
dc.identifier.issn.none.fl_str_mv 0014-2980
dc.identifier.doi.none.fl_str_mv 10.1002/eji.201545817
identifier_str_mv VENKATASUBRAMANIAN, S. et. al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. European Journal of Immunology, v. 46, p. 464–479, 2016.
0014-2980
10.1002/eji.201545817
url https://www.arca.fiocruz.br/handle/icict/13950
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Wiley-VCH Verlag
publisher.none.fl_str_mv Wiley-VCH Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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