Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/57337 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil / Universidade Federal de Ouro Preto. Escola de Farmácia. Laboratório de Desenvolvimento Galênico e Nanotecnologia. Ouro Preto, MG, Brazil / Estación Experimental Agraria Baños del Inca. Instituto Nacional de Innovación Agraria. Cajamarca, Peru. |
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González, Marco Antonio CabreraGonçalves, Ana Alice MaiaOttino, JenniferLeite, Jaqueline CostaResende, Lucilene AparecidaMelo-Júnior, Otoni AlvesSilveira, PatríciaCardoso, Mariana SantosFujiwara, Ricardo ToshioBueno, Lilian LacerdaSantos, Renato LimaCarvalho, Tatiane Furtado deGarcia, Giani MartinsPaes, Paulo Ricardo de OliveiraGaldino, Alexsandro SobreiraChávez-Fumagalli, Miguel AngelMelo, Marília MartinsSilveira-Lemos, DeniseMartins Filho, Olindo AssisDutra, Walderez OrnelasMosqueira, Vanessa Carla FurtadoGiunchetti, Rodolfo Cordeiro2023-03-13T17:12:45Z2023-03-13T17:12:45Z2023GONZÁLEZ, Marco Antonio Cabrera et al. Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster. Vaccines, v. 11, p. 1-14, 2023.2076-393Xhttps://www.arca.fiocruz.br/handle/icict/5733710.3390/vaccines11010111engMDPIVaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamsterinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil / Universidade Federal de Ouro Preto. Escola de Farmácia. Laboratório de Desenvolvimento Galênico e Nanotecnologia. Ouro Preto, MG, Brazil / Estación Experimental Agraria Baños del Inca. Instituto Nacional de Innovación Agraria. Cajamarca, Peru.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Veterinária. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Veterinária. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Escola de Farmácia. Laboratório de Desenvolvimento Galênico e Nanotecnologia. Ouro Preto, MG, Brazil.Universidade Federal de Minas Gerais. Escola de Veterinária. Belo Horizonte, MG, Brazil.Universidade Federal de São João Del-Rei. Laboratório de Biotecnologia de Microrganismos. Divinópolis, MG, Brazil.Computational Biology and Chemistry Research Group. Vicerrectorado de Investigación. Universidad Católica de Santa María. Arequipa, Peru.Universidade Federal de Minas Gerais. Escola de Veterinária. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Biomarcadores de Diagnóstico e Monitoração. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil/Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Escola de Farmácia. Laboratório de Desenvolvimento Galênico e Nanotecnologia. Ouro Preto, MG, Brazil.Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil / Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brazil / Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais. Belo Horizonte, MG, Brazil.Visceral leishmaniasis (VL) is a fatal disease caused by the protozoa Leishmania infantum for which dogs are the main reservoirs. A vaccine against canine visceral leishmaniasis (CVL) could be an important tool in the control of human and CVL by reducing the infection pressure of L. infantum. Despite the CVL vaccine available on the market, the Brazilian Ministry of Health did not implement the use of it in their control programs. In this sense, there is an urgent need to develop more efficient vaccines. In this study, the association between two polymeric nanoformulations, (poly (D, L-lactic) acid (PLA) polymer) loading Leishmania amazonensis antigens, was evaluated as a potential immunobiological agent against VL using golden hamsters as an experimental model. The results indicated that no significant adverse reactions were observed in animals vaccinated with LAPSmP. LAPSmP presented similar levels of total anti-Leishmania IgG as compared to LAPSmG. The LAPSmP and LAPSmG groups showed an intense reduction in liver and spleen parasitic load by qPCR. The LAPSmP and LAPSmG vaccines showed exceptional results, indicating that they may be promising candidates as a VL vaccine.NanotechnologyVaccineVisceral leishmaniasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/57337/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALVaccination with Formulation of Nanoparticles Loaded with.pdfVaccination with Formulation of Nanoparticles Loaded with.pdfapplication/pdf6553123https://www.arca.fiocruz.br/bitstream/icict/57337/2/Vaccination%20with%20Formulation%20of%20Nanoparticles%20Loaded%20with.pdfb9f42df1085cd3391fc7ff31fa7ccfbbMD52icict/573372023-05-26 23:39:49.757oai:www.arca.fiocruz.br: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ório 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| dc.title.en_US.fl_str_mv |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| title |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| spellingShingle |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster González, Marco Antonio Cabrera Nanotechnology Vaccine Visceral leishmaniasis |
| title_short |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| title_full |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| title_fullStr |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| title_full_unstemmed |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| title_sort |
Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster |
| author |
González, Marco Antonio Cabrera |
| author_facet |
González, Marco Antonio Cabrera Gonçalves, Ana Alice Maia Ottino, Jennifer Leite, Jaqueline Costa Resende, Lucilene Aparecida Melo-Júnior, Otoni Alves Silveira, Patrícia Cardoso, Mariana Santos Fujiwara, Ricardo Toshio Bueno, Lilian Lacerda Santos, Renato Lima Carvalho, Tatiane Furtado de Garcia, Giani Martins Paes, Paulo Ricardo de Oliveira Galdino, Alexsandro Sobreira Chávez-Fumagalli, Miguel Angel Melo, Marília Martins Silveira-Lemos, Denise Martins Filho, Olindo Assis Dutra, Walderez Ornelas Mosqueira, Vanessa Carla Furtado Giunchetti, Rodolfo Cordeiro |
| author_role |
author |
| author2 |
Gonçalves, Ana Alice Maia Ottino, Jennifer Leite, Jaqueline Costa Resende, Lucilene Aparecida Melo-Júnior, Otoni Alves Silveira, Patrícia Cardoso, Mariana Santos Fujiwara, Ricardo Toshio Bueno, Lilian Lacerda Santos, Renato Lima Carvalho, Tatiane Furtado de Garcia, Giani Martins Paes, Paulo Ricardo de Oliveira Galdino, Alexsandro Sobreira Chávez-Fumagalli, Miguel Angel Melo, Marília Martins Silveira-Lemos, Denise Martins Filho, Olindo Assis Dutra, Walderez Ornelas Mosqueira, Vanessa Carla Furtado Giunchetti, Rodolfo Cordeiro |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
González, Marco Antonio Cabrera Gonçalves, Ana Alice Maia Ottino, Jennifer Leite, Jaqueline Costa Resende, Lucilene Aparecida Melo-Júnior, Otoni Alves Silveira, Patrícia Cardoso, Mariana Santos Fujiwara, Ricardo Toshio Bueno, Lilian Lacerda Santos, Renato Lima Carvalho, Tatiane Furtado de Garcia, Giani Martins Paes, Paulo Ricardo de Oliveira Galdino, Alexsandro Sobreira Chávez-Fumagalli, Miguel Angel Melo, Marília Martins Silveira-Lemos, Denise Martins Filho, Olindo Assis Dutra, Walderez Ornelas Mosqueira, Vanessa Carla Furtado Giunchetti, Rodolfo Cordeiro |
| dc.subject.en.en_US.fl_str_mv |
Nanotechnology Vaccine Visceral leishmaniasis |
| topic |
Nanotechnology Vaccine Visceral leishmaniasis |
| description |
Universidade Federal de Minas Gerais. Departamento de Morfologia. Belo Horizonte, MG, Brazil / Universidade Federal de Ouro Preto. Escola de Farmácia. Laboratório de Desenvolvimento Galênico e Nanotecnologia. Ouro Preto, MG, Brazil / Estación Experimental Agraria Baños del Inca. Instituto Nacional de Innovación Agraria. Cajamarca, Peru. |
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2023 |
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2023-03-13T17:12:45Z |
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2023-03-13T17:12:45Z |
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2023 |
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info:eu-repo/semantics/article |
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GONZÁLEZ, Marco Antonio Cabrera et al. Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster. Vaccines, v. 11, p. 1-14, 2023. |
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https://www.arca.fiocruz.br/handle/icict/57337 |
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2076-393X |
| dc.identifier.doi.none.fl_str_mv |
10.3390/vaccines11010111 |
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GONZÁLEZ, Marco Antonio Cabrera et al. Vaccination with Formulation of Nanoparticles Loaded with Leishmania amazonensis Antigens Confers Protection against Experimental Visceral Leishmaniasis in Hamster. Vaccines, v. 11, p. 1-14, 2023. 2076-393X 10.3390/vaccines11010111 |
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