Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review

Detalhes bibliográficos
Autor(a) principal: Silva, Taylon Felipe
Data de Publicação: 2021
Outros Autores: Tomiotto-Pellissier, Fernanda, Pasquali, Aline Kuhn Sbruzzi, Pinto-Ferreira, Fernanda, Pavanelli, Wander Rogério, Conchon-Costa, Ivete, Navarro, Italmar Teodorico, Caldart, Eloiza Teles
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/50065
Resumo: Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.
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spelling Silva, Taylon FelipeTomiotto-Pellissier, FernandaPasquali, Aline Kuhn SbruzziPinto-Ferreira, FernandaPavanelli, Wander RogérioConchon-Costa, IveteNavarro, Italmar TeodoricoCaldart, Eloiza Teles2021-11-25T17:56:30Z2021-11-25T17:56:30Z2021SILVA, Taylon Felipe et al. Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review. Acta Tropica. v. 221, n. 106018, p. 1–8, 2021.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/5006510.1016/j.actatropica.2021.106018porActa TropicaLeishmania amazonensisLeishmaniasis, CutaneousLeishmaniasis, VisceralVirulenceLeishmaniasis CutáneaLeishmaniasis VisceralVirulenciaLeishmaniose cutanéeLeishmaniose viscéraleVirulenceLeishmaniose CutâneaLeishmaniose VisceralVirulênciaPhenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade do Oeste de Santa Catarina. Campos Novos, Brasil.Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Agrárias. Departamento de Medicina Veterinária Preventiva. Londrina, PR, Brasil.Leishmania (Leishmania) amazonensis is an important etiological agent of American cutaneous leishmaniasis (ACL) in Brazil. The species causes a large spectrum of clinical manifestations in humans and dogs, ranging from cutaneous, cutaneous diffuse, mucocutaneous, and visceral involvement, however, the factors that drive the development of different disease forms by the same species are not yet fully known. In the present work, it was systematically reviewed the studies addressing phenotypic and genotypic characteristics of Leishmania (L.) amazonensis isolates causing cutaneous and visceral clinical frames in humans and dogs, comparing the results observed. For this, four research databases were searched for the following keywords: (Leishmania amazonensis AND visceral leishmaniasis) AND (tropism OR virulence OR visceralization OR adaptations OR mutation OR clinical presentation OR resistance OR survival OR wide spectrum). The results revealed that the complexity disease seems to involve the combination of genetic factors of the parasite (as modifications in molecules related to the virulence and metabolism) and also of the host’s immune background and status. Nonetheless, the exact mechanism that leads to different clinical manifestations between strains of the same species is still uncertain and future studies must be developed to better elucidate this phenomenon.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/50065/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1-s2.0-S0001706X21001972-OK.pdf1-s2.0-S0001706X21001972-OK.pdfapplication/pdf678812https://www.arca.fiocruz.br/bitstream/icict/50065/2/1-s2.0-S0001706X21001972-OK.pdfe623f4f9278a49768d91a3092462d969MD52icict/500652021-11-25 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dc.title.pt_BR.fl_str_mv Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
title Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
spellingShingle Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
Silva, Taylon Felipe
Leishmania amazonensis
Leishmaniasis, Cutaneous
Leishmaniasis, Visceral
Virulence
Leishmaniasis Cutánea
Leishmaniasis Visceral
Virulencia
Leishmaniose cutanée
Leishmaniose viscérale
Virulence
Leishmaniose Cutânea
Leishmaniose Visceral
Virulência
title_short Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
title_full Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
title_fullStr Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
title_full_unstemmed Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
title_sort Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review
author Silva, Taylon Felipe
author_facet Silva, Taylon Felipe
Tomiotto-Pellissier, Fernanda
Pasquali, Aline Kuhn Sbruzzi
Pinto-Ferreira, Fernanda
Pavanelli, Wander Rogério
Conchon-Costa, Ivete
Navarro, Italmar Teodorico
Caldart, Eloiza Teles
author_role author
author2 Tomiotto-Pellissier, Fernanda
Pasquali, Aline Kuhn Sbruzzi
Pinto-Ferreira, Fernanda
Pavanelli, Wander Rogério
Conchon-Costa, Ivete
Navarro, Italmar Teodorico
Caldart, Eloiza Teles
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Silva, Taylon Felipe
Tomiotto-Pellissier, Fernanda
Pasquali, Aline Kuhn Sbruzzi
Pinto-Ferreira, Fernanda
Pavanelli, Wander Rogério
Conchon-Costa, Ivete
Navarro, Italmar Teodorico
Caldart, Eloiza Teles
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
topic Leishmania amazonensis
Leishmaniasis, Cutaneous
Leishmaniasis, Visceral
Virulence
Leishmaniasis Cutánea
Leishmaniasis Visceral
Virulencia
Leishmaniose cutanée
Leishmaniose viscérale
Virulence
Leishmaniose Cutânea
Leishmaniose Visceral
Virulência
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis, Cutaneous
Leishmaniasis, Visceral
Virulence
dc.subject.es.pt_BR.fl_str_mv Leishmaniasis Cutánea
Leishmaniasis Visceral
Virulencia
dc.subject.fr.pt_BR.fl_str_mv Leishmaniose cutanée
Leishmaniose viscérale
Virulence
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Cutânea
Leishmaniose Visceral
Virulência
description Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-25T17:56:30Z
dc.date.available.fl_str_mv 2021-11-25T17:56:30Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SILVA, Taylon Felipe et al. Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review. Acta Tropica. v. 221, n. 106018, p. 1–8, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/50065
dc.identifier.issn.pt_BR.fl_str_mv 0001-706X
dc.identifier.doi.none.fl_str_mv 10.1016/j.actatropica.2021.106018
identifier_str_mv SILVA, Taylon Felipe et al. Phenotypical and genotypical differences among Leishmania (Leishmania) amazonensis isolates that caused different clinical frames in humans and dogs: A systematic review. Acta Tropica. v. 221, n. 106018, p. 1–8, 2021.
0001-706X
10.1016/j.actatropica.2021.106018
url https://www.arca.fiocruz.br/handle/icict/50065
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dc.publisher.none.fl_str_mv Acta Tropica
publisher.none.fl_str_mv Acta Tropica
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collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/50065/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/50065/2/1-s2.0-S0001706X21001972-OK.pdf
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