The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation

Detalhes bibliográficos
Autor(a) principal: Lima, Israel Diniz
Data de Publicação: 2022
Outros Autores: Fonseca, Leonardo Marques da, Reis, Jhenifer Santos dos, Santos, Marcos André Rodrigues da Costa, Costa, Kelli Monteiro da, Santos, Carlos Antonio do Nascimento, Barcelos, Pedro Marçal, Pinto, Kamila Guimarães, Filardy, Alessandra Almeida, Lima, Marco Edilson Freire de, Ricardo, Debora Decote, Morrot, Alexandre, Lima, Celio Geraldo Freire de, Lima, Leonardo Freire de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/53600
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
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spelling Lima, Israel DinizFonseca, Leonardo Marques daReis, Jhenifer Santos dosSantos, Marcos André Rodrigues da CostaCosta, Kelli Monteiro daSantos, Carlos Antonio do NascimentoBarcelos, Pedro MarçalPinto, Kamila GuimarãesFilardy, Alessandra AlmeidaLima, Marco Edilson Freire deRicardo, Debora DecoteMorrot, AlexandreLima, Celio Geraldo Freire deLima, Leonardo Freire de2022-06-30T19:11:02Z2022-06-30T19:11:02Z2022LIMA, Israel Diniz et al. The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation. Medicines , v. 9, 37, p. 1 - 9, June 2022.2305-6320https://www.arca.fiocruz.br/handle/icict/5360010.3390/ medicines9060037engMDPIInfecção fúngicaGlicoconjugadosSistema imunológicoCitocinasFungal infectionGlycoconjugatesImmune systemCytokinesThe Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Goes. Rio de Janeiro, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Química., Departamento de Química Orgânica. Seropédica, RJ, Brasil.Universidade Federal Rural do Rio de Janeiro. Instituto de Veterinária. Departamento de Microbiologia e Imunologia Veterinária. Seropédica, RJ, Brasil.Fundação Oswaldo Cruz. Insituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.Fungal infections are the most common secondary infections in debilitated individuals in a state of chronic disease or immunosuppression. Despite this, most fungal infections are neglected, mainly due to the lower frequency of their more severe clinical forms in immunocompetent individuals with a healthy background. However, over the past few years, several cases of severe fungal infections in healthy individuals have provoked a change in the epidemiological dynamics of fungal infections around the world, both due to recurrent outbreaks in previously infrequent regions and the greater emergence of more pathogenic fungal variants affecting healthy individuals, such as in the Cryptococcus genus. Therefore, before the arrival of a scenario of prevalent severe fungal infections, it is necessary to assess more carefully what are the real reasons for the increased incidence of fungal infection globally. What are the factors that are currently contributing to this new possible epidemiological dynamic? Could these be of a structural nature? Herein, we propose a discussion based on the importance of the virulence factors of glycoconjugate composition in the adaptation of pathogenic fungal species into the current scenario of increasing severity of these infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/53600/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALIsraelDiniz_AlexandreMorrot_etal_IOC_2022.pdfIsraelDiniz_AlexandreMorrot_etal_IOC_2022.pdfapplication/pdf361879https://www.arca.fiocruz.br/bitstream/icict/53600/2/IsraelDiniz_AlexandreMorrot_etal_IOC_2022.pdfe271d28e83927332c694afdbef957ec2MD52icict/536002022-06-30 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dc.title.pt_BR.fl_str_mv The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
title The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
spellingShingle The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
Lima, Israel Diniz
Infecção fúngica
Glicoconjugados
Sistema imunológico
Citocinas
Fungal infection
Glycoconjugates
Immune system
Cytokines
title_short The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
title_full The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
title_fullStr The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
title_full_unstemmed The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
title_sort The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation
author Lima, Israel Diniz
author_facet Lima, Israel Diniz
Fonseca, Leonardo Marques da
Reis, Jhenifer Santos dos
Santos, Marcos André Rodrigues da Costa
Costa, Kelli Monteiro da
Santos, Carlos Antonio do Nascimento
Barcelos, Pedro Marçal
Pinto, Kamila Guimarães
Filardy, Alessandra Almeida
Lima, Marco Edilson Freire de
Ricardo, Debora Decote
Morrot, Alexandre
Lima, Celio Geraldo Freire de
Lima, Leonardo Freire de
author_role author
author2 Fonseca, Leonardo Marques da
Reis, Jhenifer Santos dos
Santos, Marcos André Rodrigues da Costa
Costa, Kelli Monteiro da
Santos, Carlos Antonio do Nascimento
Barcelos, Pedro Marçal
Pinto, Kamila Guimarães
Filardy, Alessandra Almeida
Lima, Marco Edilson Freire de
Ricardo, Debora Decote
Morrot, Alexandre
Lima, Celio Geraldo Freire de
Lima, Leonardo Freire de
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Israel Diniz
Fonseca, Leonardo Marques da
Reis, Jhenifer Santos dos
Santos, Marcos André Rodrigues da Costa
Costa, Kelli Monteiro da
Santos, Carlos Antonio do Nascimento
Barcelos, Pedro Marçal
Pinto, Kamila Guimarães
Filardy, Alessandra Almeida
Lima, Marco Edilson Freire de
Ricardo, Debora Decote
Morrot, Alexandre
Lima, Celio Geraldo Freire de
Lima, Leonardo Freire de
dc.subject.other.pt_BR.fl_str_mv Infecção fúngica
Glicoconjugados
Sistema imunológico
Citocinas
topic Infecção fúngica
Glicoconjugados
Sistema imunológico
Citocinas
Fungal infection
Glycoconjugates
Immune system
Cytokines
dc.subject.en.pt_BR.fl_str_mv Fungal infection
Glycoconjugates
Immune system
Cytokines
description Universidade Federal do Rio de Janeiro. Instituto de Biofisica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil.
publishDate 2022
dc.date.accessioned.fl_str_mv 2022-06-30T19:11:02Z
dc.date.available.fl_str_mv 2022-06-30T19:11:02Z
dc.date.issued.fl_str_mv 2022
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA, Israel Diniz et al. The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation. Medicines , v. 9, 37, p. 1 - 9, June 2022.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/53600
dc.identifier.issn.pt_BR.fl_str_mv 2305-6320
dc.identifier.doi.none.fl_str_mv 10.3390/ medicines9060037
identifier_str_mv LIMA, Israel Diniz et al. The Sweet Side of Fungal Infections: Structural Glycan Diversity and Its Importance for Pathogenic Adaptation. Medicines , v. 9, 37, p. 1 - 9, June 2022.
2305-6320
10.3390/ medicines9060037
url https://www.arca.fiocruz.br/handle/icict/53600
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/53600/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/53600/2/IsraelDiniz_AlexandreMorrot_etal_IOC_2022.pdf
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