Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review

Detalhes bibliográficos
Autor(a) principal: Freire, Mariana Lourenço
Data de Publicação: 2021
Outros Autores: Rêgo, Felipe Dutra, Cota, Gláucia Fernandes, Xavier, Marcelo Antônio Pascoal, Oliveira, Edward José de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51793
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
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spelling Freire, Mariana LourençoRêgo, Felipe DutraCota, Gláucia FernandesXavier, Marcelo Antônio PascoalOliveira, Edward José de2022-03-21T19:35:15Z2022-03-21T19:35:15Z2021FREIRE, Mariana Lourenço et al. Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review. PLoS One, v. 16, n. 5, e0251956, 2021. doi: 10.1371/journal.pone.0251956.1932-6203https://www.arca.fiocruz.br/handle/icict/5179310.1371/journal.pone.0251956engPublic Library of SciencePotential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.Immunological tests may represent valuable tools for the diagnosis of human tegumentary leishmaniasis (TL) due to their simple execution, less invasive nature and potential use as a point-of-care test. Indeed, several antigenic targets have been used with the aim of improving the restricted scenario for TL-diagnosis. We performed a worldwide systematic review to identify antigenic targets that have been evaluated for the main clinical forms of TL, such as cutaneous (CL) and mucosal (ML) leishmaniasis. Included were original studies evaluating the sensitivity and specificity of immunological tests for human-TL, CL and/or ML diagnosis using purified or recombinant proteins, synthetic peptides or polyclonal or monoclonal antibodies to detect Leishmania-specific antibodies or antigens. The review methodology followed PRISMA guidelines and all selected studies were evaluated in accordance with QUADAS-2. Thirty-eight original studies from four databases fulfilled the selection criteria. A total of 79 antigens were evaluated for the detection of antibodies as a diagnostic for TL, CL and/or ML by ELISA. Furthermore, three antibodies were evaluated for the detection of antigen by immunochromatographic test (ICT) and immunohistochemistry (IHC) for CL-diagnosis. Several antigenic targets showed 100% of sensitivity and specificity, suggesting potential use for TL-diagnosis in its different clinical manifestations. However, a high number of proof-of-concept studies reinforce the need for further analysis aimed at verifying true diagnostic accuracy in clinical practice.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/51793/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALPotential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis.pdfPotential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis.pdfapplication/pdf7642175https://www.arca.fiocruz.br/bitstream/icict/51793/2/Potential%20antigenic%20targets%20used%20in%20immunological%20tests%20for%20diagnosis%20of%20tegumentary%20leishmaniasis.pdf09bab6dcee495e9268d94c2125c029baMD52icict/517932022-03-21 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dc.title.pt_BR.fl_str_mv Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
title Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
spellingShingle Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
Freire, Mariana Lourenço
title_short Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
title_full Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
title_fullStr Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
title_full_unstemmed Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
title_sort Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review
author Freire, Mariana Lourenço
author_facet Freire, Mariana Lourenço
Rêgo, Felipe Dutra
Cota, Gláucia Fernandes
Xavier, Marcelo Antônio Pascoal
Oliveira, Edward José de
author_role author
author2 Rêgo, Felipe Dutra
Cota, Gláucia Fernandes
Xavier, Marcelo Antônio Pascoal
Oliveira, Edward José de
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Freire, Mariana Lourenço
Rêgo, Felipe Dutra
Cota, Gláucia Fernandes
Xavier, Marcelo Antônio Pascoal
Oliveira, Edward José de
description Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-21T19:35:15Z
dc.date.available.fl_str_mv 2022-03-21T19:35:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FREIRE, Mariana Lourenço et al. Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review. PLoS One, v. 16, n. 5, e0251956, 2021. doi: 10.1371/journal.pone.0251956.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51793
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0251956
identifier_str_mv FREIRE, Mariana Lourenço et al. Potential antigenic targets used in immunological tests for diagnosis of tegumentary leishmaniasis: A systematic review. PLoS One, v. 16, n. 5, e0251956, 2021. doi: 10.1371/journal.pone.0251956.
1932-6203
10.1371/journal.pone.0251956
url https://www.arca.fiocruz.br/handle/icict/51793
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51793/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/51793/2/Potential%20antigenic%20targets%20used%20in%20immunological%20tests%20for%20diagnosis%20of%20tegumentary%20leishmaniasis.pdf
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
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