Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51850 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. |
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Farias, Beatriz OliveiraBianco, KayoNascimento, Ana Paula AlvesGonçalves de Brito, Andressa SilvaMoreira, Thais CostaClementino, Maysa Mandetta2022-03-24T12:04:40Z2022-03-24T12:04:40Z2022FARIAS, Beatriz Oliveira et al. Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants. Microbial Drug Resistance, v. 0, n. 0, p. 1-9, 2022.1931-8448https://www.arca.fiocruz.br/handle/icict/5185010.1089/mdr.2021.0254engGenomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plantsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil.The emergence of vancomycin-resistant Enterococcus faecium (Efm) harboring vanA gene and multidrug-resistant determinants is a relevant public health concern. It is an opportunistic pathogen responsible for nosocomial infections widely distributed in the environment, including wastewater treatment plants (WWTPs). Our study addresses a genomic investigation of vanA-carrying Efm from WWTPs in Brazil. Samples from five WWTPs supplied with sewage from different sources were evaluated. Here we present whole-genome sequencing of eight vanA-Efm isolates performed on Illumina MiSeq platform. All these isolates presented multidrug-resistant profile, and five strains were from treated wastewater. Multiple antimicrobial resistance genes (ARGs) were found, such as aph(3′)-IIIa, ant(6′)-Ia, erm(B), and msrC, some of them being allocated in plasmids. The virulence profile was predominantly constituted by efaAfm and acm genes and all isolates, except for one, were predicted as human pathogens. Multilocus sequence typing analysis revealed a new allele and five different STs, three previously described (ST32, ST168, and ST253) and two novel ones (ST1893 and ST1894). Six strains belonged to CC17, often associated with hospital outbreaks. As far as our knowledge, no genomic studies of vanA-Efm recovered from WWTPs revealed isolates belonging to CC17 in Brazil. Therefore, our findings point to the environmental spread of Efm carrying multiple ARGs.Vancomycin-resistant enterococci (VRE)Antibiotic resistanceWhole-genome sequencingWastewaterEnterococos Resistentes à VancomicinaResistência Microbiana a MedicamentosSequenciamento Completo do GenomaÁguas Residuáriasinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83102https://www.arca.fiocruz.br/bitstream/icict/51850/1/license.txt3e59f4bb248f3215f9b063e1264ea7aeMD51ORIGINALmdr.2021.0254.pdfmdr.2021.0254.pdfapplication/pdf595114https://www.arca.fiocruz.br/bitstream/icict/51850/2/mdr.2021.0254.pdf698a5ecfbd42896606ede4a1f0503d0eMD52icict/518502022-06-03 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dc.title.pt_BR.fl_str_mv |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
title |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
spellingShingle |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants Farias, Beatriz Oliveira Vancomycin-resistant enterococci (VRE) Antibiotic resistance Whole-genome sequencing Wastewater Enterococos Resistentes à Vancomicina Resistência Microbiana a Medicamentos Sequenciamento Completo do Genoma Águas Residuárias |
title_short |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
title_full |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
title_fullStr |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
title_full_unstemmed |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
title_sort |
Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants |
author |
Farias, Beatriz Oliveira |
author_facet |
Farias, Beatriz Oliveira Bianco, Kayo Nascimento, Ana Paula Alves Gonçalves de Brito, Andressa Silva Moreira, Thais Costa Clementino, Maysa Mandetta |
author_role |
author |
author2 |
Bianco, Kayo Nascimento, Ana Paula Alves Gonçalves de Brito, Andressa Silva Moreira, Thais Costa Clementino, Maysa Mandetta |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Farias, Beatriz Oliveira Bianco, Kayo Nascimento, Ana Paula Alves Gonçalves de Brito, Andressa Silva Moreira, Thais Costa Clementino, Maysa Mandetta |
dc.subject.en.pt_BR.fl_str_mv |
Vancomycin-resistant enterococci (VRE) Antibiotic resistance Whole-genome sequencing Wastewater |
topic |
Vancomycin-resistant enterococci (VRE) Antibiotic resistance Whole-genome sequencing Wastewater Enterococos Resistentes à Vancomicina Resistência Microbiana a Medicamentos Sequenciamento Completo do Genoma Águas Residuárias |
dc.subject.decs.pt_BR.fl_str_mv |
Enterococos Resistentes à Vancomicina Resistência Microbiana a Medicamentos Sequenciamento Completo do Genoma Águas Residuárias |
description |
Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Rio de Janeiro, RJ, Brasil. |
publishDate |
2022 |
dc.date.accessioned.fl_str_mv |
2022-03-24T12:04:40Z |
dc.date.available.fl_str_mv |
2022-03-24T12:04:40Z |
dc.date.issued.fl_str_mv |
2022 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FARIAS, Beatriz Oliveira et al. Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants. Microbial Drug Resistance, v. 0, n. 0, p. 1-9, 2022. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/51850 |
dc.identifier.issn.pt_BR.fl_str_mv |
1931-8448 |
dc.identifier.doi.none.fl_str_mv |
10.1089/mdr.2021.0254 |
identifier_str_mv |
FARIAS, Beatriz Oliveira et al. Genomic Analysis of Multidrug-Resistant Enterococcus faecium Harboring vanA Gene from Wastewater Treatment Plants. Microbial Drug Resistance, v. 0, n. 0, p. 1-9, 2022. 1931-8448 10.1089/mdr.2021.0254 |
url |
https://www.arca.fiocruz.br/handle/icict/51850 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
collection |
Repositório Institucional da FIOCRUZ (ARCA) |
bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/51850/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/51850/2/mdr.2021.0254.pdf |
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repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
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1798324802436464640 |