Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/33047 |
Resumo: | Fundação de Amparo à Pesquisa do Estado da Bahia (BOL0575/2015). This study wasfinanced in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001. |
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Firmino, Alisson de AquinoMartins, Adenilda Lima LopesGois, Luana LeandroPaixão, Taiane SilvaBatista, Everton da SilvaCastro Filho, Bernardo GalvãoGrassi, Maria Fernanda Rios2019-05-13T16:50:08Z2019-05-13T16:50:08Z2019FIRMINO, Alisson de Aquino et al. Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women. Brazilian Journal of Infectious Diseases, v. 23, n. 1, p. 27-33, 2019.1413-8670https://www.arca.fiocruz.br/handle/icict/3304710.1016/j.bjid.2019.02.001Fundação de Amparo à Pesquisa do Estado da Bahia (BOL0575/2015). This study wasfinanced in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. Methods: HTLV-1-infected and uninfected women were selected at the Centro de Atendi-mento ao Portador de HTLV in Salvador-Brazil. None of the included HTLV-1-infected womenreported any HTLV-1-associated diseases. All volunteers underwent gynecological exam-ination to collect cervicovaginal fluid. Cytokine quantification was performed using theCytometric Bead Array (CBA) Human Th1/Th2/Th17 kit. Light microscopy was used to eval-uate cervicovaginal cytopathology. In addition, proviral load in cervicovaginal fluid andperipheral blood was measured by real-time quantitative polymerase chain reaction.Results: 112 women (63 HTLV-1-infected and 49 uninfected) were evaluated. No differenceswere found with respect to cytopathological cervicovaginal findings between the groups.IL-2, TNF, IL-4, IL-10, and IL-17 levels were significantly higher in cervicovaginal fluid of theHTLV-1-infected women than in uninfected women (p < 0.05). Conversely, IFN- was foundto be lower in the HTLV-1-infected women (p < 0.001) compared to uninfected individuals.Cervicovaginal proviral load was detectable in 53% of the HTLV-1-infected women and wasfound to be consistently lower than the proviral load in peripheral blood.Conclusions: HTLV-1 infection induces immune activation in cervicovaginal environment.engElsevierHTLV-1Citocinas InflamatóriasCarga ProviralCitopatologia cervicovaginalHTLV-1Inflammatory cytokinesProviral loadCervicovaginal cytopathologyEvaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/33047/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFirmino A.A. Evaluation cervicovaginal... 2019.pdfFirmino A.A. Evaluation cervicovaginal... 2019.pdfapplication/pdf849550https://www.arca.fiocruz.br/bitstream/icict/33047/2/Firmino%20A.A.%20%20Evaluation%20cervicovaginal...%202019.pdf5fb3f3c5efe369679dc46a6234fb6f34MD52TEXTFirmino A.A. Evaluation cervicovaginal... 2019.pdf.txtFirmino A.A. 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| dc.title.pt_BR.fl_str_mv |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| title |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| spellingShingle |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women Firmino, Alisson de Aquino HTLV-1 Citocinas Inflamatórias Carga Proviral Citopatologia cervicovaginal HTLV-1 Inflammatory cytokines Proviral load Cervicovaginal cytopathology |
| title_short |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| title_full |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| title_fullStr |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| title_full_unstemmed |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| title_sort |
Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women |
| author |
Firmino, Alisson de Aquino |
| author_facet |
Firmino, Alisson de Aquino Martins, Adenilda Lima Lopes Gois, Luana Leandro Paixão, Taiane Silva Batista, Everton da Silva Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| author_role |
author |
| author2 |
Martins, Adenilda Lima Lopes Gois, Luana Leandro Paixão, Taiane Silva Batista, Everton da Silva Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Firmino, Alisson de Aquino Martins, Adenilda Lima Lopes Gois, Luana Leandro Paixão, Taiane Silva Batista, Everton da Silva Castro Filho, Bernardo Galvão Grassi, Maria Fernanda Rios |
| dc.subject.other.pt_BR.fl_str_mv |
HTLV-1 Citocinas Inflamatórias Carga Proviral Citopatologia cervicovaginal |
| topic |
HTLV-1 Citocinas Inflamatórias Carga Proviral Citopatologia cervicovaginal HTLV-1 Inflammatory cytokines Proviral load Cervicovaginal cytopathology |
| dc.subject.en.pt_BR.fl_str_mv |
HTLV-1 Inflammatory cytokines Proviral load Cervicovaginal cytopathology |
| description |
Fundação de Amparo à Pesquisa do Estado da Bahia (BOL0575/2015). This study wasfinanced in part by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001. |
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2019 |
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2019-05-13T16:50:08Z |
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2019-05-13T16:50:08Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FIRMINO, Alisson de Aquino et al. Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women. Brazilian Journal of Infectious Diseases, v. 23, n. 1, p. 27-33, 2019. |
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https://www.arca.fiocruz.br/handle/icict/33047 |
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1413-8670 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.bjid.2019.02.001 |
| identifier_str_mv |
FIRMINO, Alisson de Aquino et al. Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymphotropic virus type 1 infected women. Brazilian Journal of Infectious Diseases, v. 23, n. 1, p. 27-33, 2019. 1413-8670 10.1016/j.bjid.2019.02.001 |
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