Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/18232 |
Resumo: | Texto completo: acesso restrito. p. 1809–1817 |
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Santos, Silvane Maria BragaOliveira, PauloLuna, TaniaSouza, Anselmo de SantanaNascimento, MárciaSiqueira, IsadoraTanajura, DaviMuniz, André Luís NunesGlesby, Marshall J.Carvalho Filho, Edgar Marcelino deSantos, Silvane Maria BragaOliveira, PauloLuna, TaniaSouza, Anselmo de SantanaNascimento, MárciaSiqueira, IsadoraTanajura, DaviMuniz, André Luís NunesGlesby, Marshall J.Carvalho Filho, Edgar Marcelino de2015-11-18T15:03:39Z20120146-6615http://repositorio.ufba.br/ri/handle/ri/18232v. 84, n. 11Texto completo: acesso restrito. p. 1809–1817The majority of patients infected with human T-cell lymphotropic virus-type 1 (HTLV-1) are considered carriers, but a high frequency of urinary symptoms of overactive bladder, common in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) have been documented in these patients. The aim of this study was to determine if immunological and viral factors that are seen in HAM/TSP are also observed in these patients. Participants were classified as HTLV-1 carriers (n = 45), HTLV-1 patients suffering from overactive bladder (n = 45) and HAM/TSP (n = 45). Cells from HTLV-1 overactive bladder patients produced spontaneously more proinflammatory cytokines than carriers. TNF-α and IL-17 levels were similar in HAM/TSP and HTLV-1 overactive bladder patients. High proviral load was found in patients with overactive bladder and HAM/TSP and correlated with proinflammatory cytokines. In contrast with findings in patients with HAM/TSP, serum levels of Th1 chemokines were similar in HTLV-1 overactive bladder and carriers. Exogenous addition of regulatory cytokines decreased spontaneous IFN-γ production in cell cultures from HTLV-1 overactive bladder patients. The results show that HTLV-1 overactive bladder and HAM/TSP patients have in common some immunological features as well as similar proviral load profile. The data show that HTLV-1 overactive bladder patients are still able to down regulate their inflammatory immune response. In addition, these patients express levels of chemokines similar to carriers, which may explain why they have yet to develop the same degree of spinal cord damage as seen in patients with HAM/TSP. These patients present symptoms of overactive bladder, which may be an early sign of HAM/TSP. J. Med. Virol. 84:1809–1817, 2012. © 2012 Wiley Periodicals, Inc.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-13T14:04:34Z No. of bitstreams: 1 Silvane Braga Santos.pdf: 223783 bytes, checksum: 8168c5981528ed595caf1f27698ee774 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2015-11-18T15:03:39Z (GMT) No. of bitstreams: 1 Silvane Braga Santos.pdf: 223783 bytes, checksum: 8168c5981528ed595caf1f27698ee774 (MD5)Made available in DSpace on 2015-11-18T15:03:39Z (GMT). No. of bitstreams: 1 Silvane Braga Santos.pdf: 223783 bytes, checksum: 8168c5981528ed595caf1f27698ee774 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1002/jmv.23341reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAHTLV-1Immune responseCytokinesChemokinesProviral loadImmunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infectionJournal of Medical Virologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/18232/2/license.txt0d4b811ef71182510d2015daa7c8a900MD52ORIGINALSilvane Braga Santos.pdfSilvane Braga Santos.pdfapplication/pdf223783https://repositorio.ufba.br/bitstream/ri/18232/1/Silvane%20Braga%20Santos.pdf8168c5981528ed595caf1f27698ee774MD51TEXTSilvane Braga Santos.pdf.txtSilvane Braga Santos.pdf.txtExtracted texttext/plain44126https://repositorio.ufba.br/bitstream/ri/18232/3/Silvane%20Braga%20Santos.pdf.txt399a9ddbf8cb7346b7321417dc3b2e44MD53ri/182322022-08-08 13:20:14.503oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:20:14Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Medical Virology |
| title |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| spellingShingle |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection Santos, Silvane Maria Braga HTLV-1 Immune response Cytokines Chemokines Proviral load |
| title_short |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| title_full |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| title_fullStr |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| title_full_unstemmed |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| title_sort |
Immunological and viral features in patients with overactive bladder associated with human T-cell lymphotropic virus type 1 infection |
| author |
Santos, Silvane Maria Braga |
| author_facet |
Santos, Silvane Maria Braga Oliveira, Paulo Luna, Tania Souza, Anselmo de Santana Nascimento, Márcia Siqueira, Isadora Tanajura, Davi Muniz, André Luís Nunes Glesby, Marshall J. Carvalho Filho, Edgar Marcelino de |
| author_role |
author |
| author2 |
Oliveira, Paulo Luna, Tania Souza, Anselmo de Santana Nascimento, Márcia Siqueira, Isadora Tanajura, Davi Muniz, André Luís Nunes Glesby, Marshall J. Carvalho Filho, Edgar Marcelino de |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santos, Silvane Maria Braga Oliveira, Paulo Luna, Tania Souza, Anselmo de Santana Nascimento, Márcia Siqueira, Isadora Tanajura, Davi Muniz, André Luís Nunes Glesby, Marshall J. Carvalho Filho, Edgar Marcelino de Santos, Silvane Maria Braga Oliveira, Paulo Luna, Tania Souza, Anselmo de Santana Nascimento, Márcia Siqueira, Isadora Tanajura, Davi Muniz, André Luís Nunes Glesby, Marshall J. Carvalho Filho, Edgar Marcelino de |
| dc.subject.por.fl_str_mv |
HTLV-1 Immune response Cytokines Chemokines Proviral load |
| topic |
HTLV-1 Immune response Cytokines Chemokines Proviral load |
| description |
Texto completo: acesso restrito. p. 1809–1817 |
| publishDate |
2012 |
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2012 |
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2015-11-18T15:03:39Z |
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0146-6615 |
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v. 84, n. 11 |
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0146-6615 v. 84, n. 11 |
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