Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35117 |
Resumo: | Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil. |
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Oliveira, Ayisa Rodrigues dePinheiro, Guilherme Rafael GomideTinoco, Herlandes P.Loyola, Maria ElviraCoelho, Carlyle MendesDias, Edelberto SantosMonteiro, Érika MichalskySilva, Fabiana de Oliveira Lara ePessanha, Angela TinocoSouza, Andreza Geisiane MaiaPereira, Nathália Cristina LimaFujiwara, Ricardo ToshioPaixão, Tatiane Alves daSantos, Renato Lima2019-08-27T16:12:01Z2019-08-27T16:12:01Z2019OLIVEIRA, Ayisa Rodrigues de et al. Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis. PLoS Neglected Tropical Diseases, v. 13, n. 4, p. 1-14, 2019.1935-2735https://www.arca.fiocruz.br/handle/icict/3511710.1371/journal.pntd.0007313engPublic Library of ScienceCompetence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil.Prefeitura de Belo Horizonte. Fundação de Parques Municipais e Zoobotânica. Belo Horizonte, MG, Brasil.Prefeitura de Belo Horizonte. Fundação de Parques Municipais e Zoobotânica. Belo Horizonte, MG, Brasil.Prefeitura de Belo Horizonte. Fundação de Parques Municipais e Zoobotânica. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação de Parques Municipais e Zoobotânica de Belo Horizonte, Belo Horizonte, Minas Gerais, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Fundação Oswaldo Cruz. Instituto René Rachou. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil.Leishmaniasis is a zoonotic disease of worldwide relevance. Visceral leishmaniasis is endemic in Brazil, where it is caused by Leishmania infantum with Lutzomyia longipalpis being the most important invertebrate vector. Non-human primates are susceptible to L. infantum infection. However, little is known about the role of these species as reservoirs. The aim of this study was to evaluate the transmissibility potential of visceral leishmaniasis by non-human primates through xenodiagnosis using the phlebotomine Lu. longipalpis as well as to identify phlebotomine species prevalent in the area where the primates were kept in captivity, and assess infection by Leishmania in captured phlebotomine specimens. Fifty two non-human primates kept in captivity in an endemic area for leishmaniasis were subjected to xenodiagnosis. All primates were serologically tested for detection of anti-Leishmania antibodies. Additionally, an anti-Lu. longipalpis saliva ELISA was performed. Sand flies fed on all animals were tested by qPCR to identify and quantify L. infantum promastigotes. Eight of the 52 non-human primates were positive by xenodiagnosis, including three Pan troglodytes, three Leontopithecus rosalia, one Sapajus apella, and one Miopithecus talapoin, with estimated numbers of promastigotes ranging from 5.67 to 1,181.93 per μg of DNA. Positive animals had higher levels of IgG anti-Lu. longipalpis saliva when compared to negative animals, prior to xenodiagnosis. Captive non-human primates are capable of infecting Lu. longipalpis with L. infantum. Our findings also demonstrate the relevance of non-human primates as sentinels to zoonotic diseases. Several phlebotomine species, including Lu. longipalpis, have been identified in the area where the primates were maintained, but only one pool of Lutzomyia lenti was infected with L. infantum. This study has implications for public health strategies and conservation medicine.LeishmaniasisVisceral leishmaniasisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83082https://www.arca.fiocruz.br/bitstream/icict/35117/1/license.txt9193a7c197bc67acd023525e72a03240MD51ORIGINALCompetence of non-human primates.pdfCompetence of non-human primates.pdfapplication/pdf6543660https://www.arca.fiocruz.br/bitstream/icict/35117/2/Competence%20of%20non-human%20primates.pdf6bedef80032581408bfc88ae0e5871e3MD52TEXTCompetence of non-human primates.pdf.txtCompetence of non-human primates.pdf.txtExtracted texttext/plain1872https://www.arca.fiocruz.br/bitstream/icict/35117/3/Competence%20of%20non-human%20primates.pdf.txte4deb5626854ba7564cc4d38c138f535MD53icict/351172019-08-30 21:35:04.352oai:www.arca.fiocruz.br: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Repositório 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| dc.title.pt_BR.fl_str_mv |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| title |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| spellingShingle |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis Oliveira, Ayisa Rodrigues de Leishmaniasis Visceral leishmaniasis |
| title_short |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| title_full |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| title_fullStr |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| title_full_unstemmed |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| title_sort |
Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis |
| author |
Oliveira, Ayisa Rodrigues de |
| author_facet |
Oliveira, Ayisa Rodrigues de Pinheiro, Guilherme Rafael Gomide Tinoco, Herlandes P. Loyola, Maria Elvira Coelho, Carlyle Mendes Dias, Edelberto Santos Monteiro, Érika Michalsky Silva, Fabiana de Oliveira Lara e Pessanha, Angela Tinoco Souza, Andreza Geisiane Maia Pereira, Nathália Cristina Lima Fujiwara, Ricardo Toshio Paixão, Tatiane Alves da Santos, Renato Lima |
| author_role |
author |
| author2 |
Pinheiro, Guilherme Rafael Gomide Tinoco, Herlandes P. Loyola, Maria Elvira Coelho, Carlyle Mendes Dias, Edelberto Santos Monteiro, Érika Michalsky Silva, Fabiana de Oliveira Lara e Pessanha, Angela Tinoco Souza, Andreza Geisiane Maia Pereira, Nathália Cristina Lima Fujiwara, Ricardo Toshio Paixão, Tatiane Alves da Santos, Renato Lima |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Oliveira, Ayisa Rodrigues de Pinheiro, Guilherme Rafael Gomide Tinoco, Herlandes P. Loyola, Maria Elvira Coelho, Carlyle Mendes Dias, Edelberto Santos Monteiro, Érika Michalsky Silva, Fabiana de Oliveira Lara e Pessanha, Angela Tinoco Souza, Andreza Geisiane Maia Pereira, Nathália Cristina Lima Fujiwara, Ricardo Toshio Paixão, Tatiane Alves da Santos, Renato Lima |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Visceral leishmaniasis |
| topic |
Leishmaniasis Visceral leishmaniasis |
| description |
Universidade Federal de Minas Gerais. Escola de Veterinária. Departamento de Clínica e Cirurgia Veterinárias. Belo Horizonte, MG, Brasil. |
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2019 |
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2019-08-27T16:12:01Z |
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2019-08-27T16:12:01Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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OLIVEIRA, Ayisa Rodrigues de et al. Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis. PLoS Neglected Tropical Diseases, v. 13, n. 4, p. 1-14, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35117 |
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1935-2735 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0007313 |
| identifier_str_mv |
OLIVEIRA, Ayisa Rodrigues de et al. Competence of non-human primates to transmit Leishmania infantum to the invertebrate vector Lutzomyia longipalpis. PLoS Neglected Tropical Diseases, v. 13, n. 4, p. 1-14, 2019. 1935-2735 10.1371/journal.pntd.0007313 |
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Public Library of Science |
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