A Low-Cost Open Source Device for Cell Microencapsulation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/45549 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil / Centro Universitário de Volta Redonda. UniFOA. Volta Redonda, RJ, Brasil. |
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Pereira, Miriam SallesCardoso, Liana Monteiro da FonsecaSilva, Tatiane Barreto daTeixeira, Ayla JosmaMizrahi, Saul EliahúFerreira, Gabriel Schonwandt MendesDantas, Fabio Moyses LinsAlmeida, Vinicius Cotta deAlves, Luiz Anastacio2021-01-10T15:15:56Z2021-01-10T15:15:56Z2020PEREIRA, Miriam Salles et al. A Low-Cost Open Source Device for Cell Microencapsulation. Materials, v. 13, p. 1-14, Nov. 2020.1996-1944https://www.arca.fiocruz.br/handle/icict/4554910.3390/ma13225090engMDPIAlginatoImpressora 3DMicroencapsulaçãoTransplante celularTerapia celularAlginate3D printerMicroencapsulationCell transplantationCell therapyA Low-Cost Open Source Device for Cell Microencapsulationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil / Centro Universitário de Volta Redonda. UniFOA. Volta Redonda, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Tecnologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Tecnologia. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Tecnologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Instituto Nacional de Ciência e Tecnologia em Neuroimunomodulação. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil.Microencapsulation is a widely studied cell therapy and tissue bioengineering technique, since it is capable of creating an immune-privileged site, protecting encapsulated cells from the host immune system. Several polymers have been tested, but sodium alginate is in widespread use for cell encapsulation applications, due to its low toxicity and easy manipulation. Di erent cell encapsulation methods have been described in the literature using pressure di erences or electrostatic changes with high cost commercial devices (about 30,000 US dollars). Herein, a low-cost device (about 100 US dollars) that can be created by commercial syringes or 3D printer devices has been developed. The capsules, whose diameter is around 500 mand can decrease or increase according to the pressure applied to the system, is able to maintain cells viable and functional. The hydrogel porosity of the capsule indicates that the immune system is not capable of destroying host cells, demonstrating that new studies can be developed for cell therapy at low cost with microencapsulation production. This device may aid pre-clinical and clinical projects in low- and middle-income countries and is lined up with open source equipment devices.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/45549/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMiriamSPereira_ViniciusCAlmeida_etal_IOC_2020.pdfMiriamSPereira_ViniciusCAlmeida_etal_IOC_2020.pdfapplication/pdf3380434https://www.arca.fiocruz.br/bitstream/icict/45549/2/MiriamSPereira_ViniciusCAlmeida_etal_IOC_2020.pdf060868bcca1c18ea541258eeb186c917MD52TEXTMiriamSPereira_ViniciusCAlmeida_etal_IOC_2020.pdf.txtMiriamSPereira_ViniciusCAlmeida_etal_IOC_2020.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
A Low-Cost Open Source Device for Cell Microencapsulation |
| title |
A Low-Cost Open Source Device for Cell Microencapsulation |
| spellingShingle |
A Low-Cost Open Source Device for Cell Microencapsulation Pereira, Miriam Salles Alginato Impressora 3D Microencapsulação Transplante celular Terapia celular Alginate 3D printer Microencapsulation Cell transplantation Cell therapy |
| title_short |
A Low-Cost Open Source Device for Cell Microencapsulation |
| title_full |
A Low-Cost Open Source Device for Cell Microencapsulation |
| title_fullStr |
A Low-Cost Open Source Device for Cell Microencapsulation |
| title_full_unstemmed |
A Low-Cost Open Source Device for Cell Microencapsulation |
| title_sort |
A Low-Cost Open Source Device for Cell Microencapsulation |
| author |
Pereira, Miriam Salles |
| author_facet |
Pereira, Miriam Salles Cardoso, Liana Monteiro da Fonseca Silva, Tatiane Barreto da Teixeira, Ayla Josma Mizrahi, Saul Eliahú Ferreira, Gabriel Schonwandt Mendes Dantas, Fabio Moyses Lins Almeida, Vinicius Cotta de Alves, Luiz Anastacio |
| author_role |
author |
| author2 |
Cardoso, Liana Monteiro da Fonseca Silva, Tatiane Barreto da Teixeira, Ayla Josma Mizrahi, Saul Eliahú Ferreira, Gabriel Schonwandt Mendes Dantas, Fabio Moyses Lins Almeida, Vinicius Cotta de Alves, Luiz Anastacio |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pereira, Miriam Salles Cardoso, Liana Monteiro da Fonseca Silva, Tatiane Barreto da Teixeira, Ayla Josma Mizrahi, Saul Eliahú Ferreira, Gabriel Schonwandt Mendes Dantas, Fabio Moyses Lins Almeida, Vinicius Cotta de Alves, Luiz Anastacio |
| dc.subject.other.pt_BR.fl_str_mv |
Alginato Impressora 3D Microencapsulação Transplante celular Terapia celular |
| topic |
Alginato Impressora 3D Microencapsulação Transplante celular Terapia celular Alginate 3D printer Microencapsulation Cell transplantation Cell therapy |
| dc.subject.en.pt_BR.fl_str_mv |
Alginate 3D printer Microencapsulation Cell transplantation Cell therapy |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Comunicação Celular. Rio de Janeiro, RJ, Brasil / Centro Universitário de Volta Redonda. UniFOA. Volta Redonda, RJ, Brasil. |
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2020 |
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2020 |
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2021-01-10T15:15:56Z |
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2021-01-10T15:15:56Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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PEREIRA, Miriam Salles et al. A Low-Cost Open Source Device for Cell Microencapsulation. Materials, v. 13, p. 1-14, Nov. 2020. |
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https://www.arca.fiocruz.br/handle/icict/45549 |
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1996-1944 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/ma13225090 |
| identifier_str_mv |
PEREIRA, Miriam Salles et al. A Low-Cost Open Source Device for Cell Microencapsulation. Materials, v. 13, p. 1-14, Nov. 2020. 1996-1944 10.3390/ma13225090 |
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MDPI |
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MDPI |
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