Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 1995 |
| Outros Autores: | , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/22866 |
Resumo: | Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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Costa, Jackson Mauricio LopesMoraes, Marta Solange CSaldanha, Ana Cristina RodriguesBarral, Aldina Maria PradoBurattini, Marcelo Nascimento2017-10-18T16:27:42Z2017-10-18T16:27:42Z1995COSTA, J. M. L. et al. Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 28, n. 4, p. 405-407, 1995.0037-8682https://www.arca.fiocruz.br/handle/icict/22866Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.05 autores relatam o caso de um paciente procedente de Bacabal, MA, portador de leishmaniose cutânea difusa (LCD) há 9 anos, apresentando um total de 168 lesões distribuídas pelo corpo, de caráter nódulo tumoral e algumas ulceradas, tendo sido submetido a tratamentos anteriores á base de antimonial pentavalente (glucantime® ) e associação interferom gamma+glucantime® com melhora e posterior recidiva das lesões. Recentemente quando da utilização do medicamento isotianato de pentamidina (pentacarina t® ) na dose de 4mg/kg/peso/dia, aplicados 1M em dias alternados em 3 séries de 20, 10, 10 aplicações com intervalos entre as séries de 3 meses. Na evolução do tratamento desenvolveu um quadro de perda de peso 10kg, polidpsia, poliúria, xerostomia, lesões de membros inferiores com sinais de atividade. Glicemia em jejum 420mg/dl, presença de glicose e corpos cetônicos na urina. Instituída insulinoterapia houve melhora do quadro e retorno dos níveis glicêmicos permanecendo estável até o presente momento. Alerta-se os clínicos que devido a disponibilidade da pentamidina como opção terapêutica, a mesma deve ser usada com critérios, obedecendo rigoroso controle laboratorial incluindo os níveis glicêmicos dos pacientesThe authors report a case of a male patient from Bacabal, MA with diffuse cutaneous leishmaniasis (DCL), for at least nine years, with 168 lesions on his body. These were tumour-like nodules with some ulceratmi. He used pentavalent antimonial (glucantime®) and an association of gamma interferon plus glucantime with improvement of the lesions but relapsed later. Recently, pentamidine isethionate (pentacarinat®) was given a dosage of 4mg/kg/weight/day on alternate days for 20 applications. After 3 months a similar course o f 10 application was given 2 times. Later he developed diabetic signs with weight loss of 10kg, polydypsia, polyuria and xerostomia. The lower limbs lesions showed signs of activity. Blood glucose levels normalised and remain like this at moment. Attention is drawn to the fact that pentamidine isethionate should be used as a therapy option with care, obeyng rigorous laboratory controls including a glucose tolerance test.Universidade Federal do Maranhão. Faculdade de Medicina. Departamento de Patologia. São Luís, MA, BrasilUniversidade Federal do Maranhão. Faculdade de Medicina. Departamento de Patologia. São Luís, MA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilEscola Paulista de Medicina. São Paulo, SP, BrasilengSociedade Brasileira de Medicina TropicalLeishmaniose cutânea difusaIsotionato de pentamidinaDiabetes mellitusBrasilDiffuse cutaneous leishmaniasisPentamidine isethionateDiabetes mellitusMaranhão StateDiabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22866/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCosta JML Diabetes mellitus....pdfCosta JML Diabetes mellitus....pdfapplication/pdf199311https://www.arca.fiocruz.br/bitstream/icict/22866/2/Costa%20JML%20Diabetes%20mellitus....pdfea2a4cf360d063e15efb9f68eb828610MD52TEXTCosta JML Diabetes mellitus....pdf.txtCosta JML Diabetes mellitus....pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| title |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| spellingShingle |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis Costa, Jackson Mauricio Lopes Leishmaniose cutânea difusa Isotionato de pentamidina Diabetes mellitus Brasil Diffuse cutaneous leishmaniasis Pentamidine isethionate Diabetes mellitus Maranhão State |
| title_short |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| title_full |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| title_fullStr |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| title_full_unstemmed |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| title_sort |
Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis |
| author |
Costa, Jackson Mauricio Lopes |
| author_facet |
Costa, Jackson Mauricio Lopes Moraes, Marta Solange C Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Burattini, Marcelo Nascimento |
| author_role |
author |
| author2 |
Moraes, Marta Solange C Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Burattini, Marcelo Nascimento |
| author2_role |
author author author author |
| dc.contributor.author.fl_str_mv |
Costa, Jackson Mauricio Lopes Moraes, Marta Solange C Saldanha, Ana Cristina Rodrigues Barral, Aldina Maria Prado Burattini, Marcelo Nascimento |
| dc.subject.other.pt_BR.fl_str_mv |
Leishmaniose cutânea difusa Isotionato de pentamidina Diabetes mellitus Brasil |
| topic |
Leishmaniose cutânea difusa Isotionato de pentamidina Diabetes mellitus Brasil Diffuse cutaneous leishmaniasis Pentamidine isethionate Diabetes mellitus Maranhão State |
| dc.subject.en.pt_BR.fl_str_mv |
Diffuse cutaneous leishmaniasis Pentamidine isethionate Diabetes mellitus Maranhão State |
| description |
Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”. |
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1995 |
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1995 |
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2017-10-18T16:27:42Z |
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2017-10-18T16:27:42Z |
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info:eu-repo/semantics/article |
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article |
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COSTA, J. M. L. et al. Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 28, n. 4, p. 405-407, 1995. |
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0037-8682 |
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COSTA, J. M. L. et al. Diabetes Mellitus Associated with Pentamidine Isethionate in Diffuse Cutaneous Leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 28, n. 4, p. 405-407, 1995. 0037-8682 |
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Sociedade Brasileira de Medicina Tropical |
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Sociedade Brasileira de Medicina Tropical |
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