A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma

Detalhes bibliográficos
Autor(a) principal: Athanazio, Paulo Roberto Fontes
Data de Publicação: 2014
Outros Autores: Santos, Andréia Carvalho dos, Freitas, Luiz Antonio Rodrigues de, Athanazio, Daniel Abensur
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9715
Resumo: IMAGEPAT Laboratory of Pathology. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Patologia. Salvador, BA, Brasil
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spelling Athanazio, Paulo Roberto FontesSantos, Andréia Carvalho dosFreitas, Luiz Antonio Rodrigues deAthanazio, Daniel Abensur2015-03-17T12:51:28Z2015-03-17T12:51:28Z2014ATHANAZIO, P. R. F. et al. A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma. Pathology – Research and Practice, v. 210, p. 312–317, 2014.0344-0338https://www.arca.fiocruz.br/handle/icict/9715dx.doi.org/10.1016/j.prp.2014.02.002engElsevierA modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleIMAGEPAT Laboratory of Pathology. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Patologia. Salvador, BA, BrasilIMAGEPAT Laboratory of Pathology. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilIMAGEPAT Laboratory of Pathology. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Departamento de Patologia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThis study reports a modified point-count method for quantifying the extent of carcinoma in prostatectomy specimens (n = 143), as adapted from Billis et al. (2003) [3]. The prostates were studied as follows: the basal/apical margins were sampled using the cone method. The remainder of the gland was divided into 12 quadrant-shaped regions that were sampled using two slices. Eight equidistant points were marked directly on the coverslip over each fragment. The points inside the tumoral areas were counted and expressed as both the percentage of prostate gland involvement by carcinoma (PGI) and the tumor volume (TV). A significant correlation between the preoperative PSA levels and each of the three quantitative estimations were observed, with improved correlations with the PGI and TV values obtained using the point-count method (viz. number of slices involved (NSI) (r = 0.32), PGI (r = 0.39) and TV (r = 0.44)). With the data sets stratified into three categories, all three methods correlated with multiple parameters, including Gleason scores ≥7, primary Gleason scores ≥4, perineural/angiolymphatic invasion, extraprostatic extension, seminal vesicle invasion and positive margins. All three quantitative methods were associated with morphologic features of tumor progression. The results obtained using this modified point-count method correlate more strongly with preoperative PSA levels.Prostatic neoplasmsPathologyProstate-specific antigenTumor burdenNeoplasias da Próstata/patologiaBiópsia por AgulhaHumanosMasculinoInvasividade Neoplásica/diagnósticoValor Preditivo dos TestesProstatectomia/métodosNeoplasias da Próstata/diagnósticoCarga Tumoral/fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9715/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALAthanazio PRF A modified....pdfAthanazio PRF A modified....pdfapplication/pdf722220https://www.arca.fiocruz.br/bitstream/icict/9715/2/Athanazio%20PRF%20A%20modified....pdf5fd25e968157eb8e0b5f8d0b6bb769b3MD52TEXTAthanazio PRF A modified....pdf.txtAthanazio PRF A modified....pdf.txtExtracted texttext/plain40442https://www.arca.fiocruz.br/bitstream/icict/9715/3/Athanazio%20PRF%20A%20modified....pdf.txtf14b26a08c9305973b52f99b1fe1c5a3MD53icict/97152023-03-15 14:33:27.556oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:27Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
title A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
spellingShingle A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
Athanazio, Paulo Roberto Fontes
Prostatic neoplasms
Pathology
Prostate-specific antigen
Tumor burden
Neoplasias da Próstata/patologia
Biópsia por Agulha
Humanos
Masculino
Invasividade Neoplásica/diagnóstico
Valor Preditivo dos Testes
Prostatectomia/métodos
Neoplasias da Próstata/diagnóstico
Carga Tumoral/fisiologia
title_short A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
title_full A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
title_fullStr A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
title_full_unstemmed A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
title_sort A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma
author Athanazio, Paulo Roberto Fontes
author_facet Athanazio, Paulo Roberto Fontes
Santos, Andréia Carvalho dos
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
author_role author
author2 Santos, Andréia Carvalho dos
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
author2_role author
author
author
dc.contributor.author.fl_str_mv Athanazio, Paulo Roberto Fontes
Santos, Andréia Carvalho dos
Freitas, Luiz Antonio Rodrigues de
Athanazio, Daniel Abensur
dc.subject.en.pt_BR.fl_str_mv Prostatic neoplasms
Pathology
Prostate-specific antigen
Tumor burden
topic Prostatic neoplasms
Pathology
Prostate-specific antigen
Tumor burden
Neoplasias da Próstata/patologia
Biópsia por Agulha
Humanos
Masculino
Invasividade Neoplásica/diagnóstico
Valor Preditivo dos Testes
Prostatectomia/métodos
Neoplasias da Próstata/diagnóstico
Carga Tumoral/fisiologia
dc.subject.decs.pt_BR.fl_str_mv Neoplasias da Próstata/patologia
Biópsia por Agulha
Humanos
Masculino
Invasividade Neoplásica/diagnóstico
Valor Preditivo dos Testes
Prostatectomia/métodos
Neoplasias da Próstata/diagnóstico
Carga Tumoral/fisiologia
description IMAGEPAT Laboratory of Pathology. Salvador, BA, Brasil / Universidade Federal da Bahia. Departamento de Patologia. Salvador, BA, Brasil
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-03-17T12:51:28Z
dc.date.available.fl_str_mv 2015-03-17T12:51:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ATHANAZIO, P. R. F. et al. A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma. Pathology – Research and Practice, v. 210, p. 312–317, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9715
dc.identifier.issn.none.fl_str_mv 0344-0338
dc.identifier.doi.none.fl_str_mv dx.doi.org/10.1016/j.prp.2014.02.002
identifier_str_mv ATHANAZIO, P. R. F. et al. A modified point count method as a practical approach to assess the tumor volume and the percent gland involvement by prostate carcinoma. Pathology – Research and Practice, v. 210, p. 312–317, 2014.
0344-0338
dx.doi.org/10.1016/j.prp.2014.02.002
url https://www.arca.fiocruz.br/handle/icict/9715
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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