Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas

Detalhes bibliográficos
Autor(a) principal: Gomes, Larissa Rodrigues
Data de Publicação: 2016
Outros Autores: Oliveira, Natália Ketrin Almeida de, Lavigne, Aline Rosa de, Lima, Suelen Rezende Félix de, Costa, Anielle de Pina, Brasil, Patrícia, Daniel-Ribeiro, Cláudio Tadeu, Ménard, Didier, Cruz, Maria de Fátima Ferreira da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16573
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.
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spelling Gomes, Larissa RodriguesOliveira, Natália Ketrin Almeida deLavigne, Aline Rosa deLima, Suelen Rezende Félix deCosta, Anielle de PinaBrasil, PatríciaDaniel-Ribeiro, Cláudio TadeuMénard, DidierCruz, Maria de Fátima Ferreira da2016-12-27T12:44:02Z2016-12-27T12:44:02Z2016GOMES, Larissa Rodrigues et al. Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non‑endemic Brazilian areas. Malaria Journal, v. 15, n. 96, p. 1-5, 2016.1475-2875https://www.arca.fiocruz.br/handle/icict/1657310.1186/s12936-016-1141-9engBioMed CentralPlasmodium vivaxResistência à cloroquinaBrasilPlasmodium vivaxChloroquine resistancePvmdr1 geneBrazilPlasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areasinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas (INI-IPEC). Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas (INI-IPEC). Laboratório de Doenças Febris Agudas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Institut Pasteur in Cambodia. Malaria Molecular Epidemiology Unit. Phnom Penh, Cambodia.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.Plasmodium vivax is the most widely distributed species causing the highest number of malaria cases in the world. In Brazil, P. vivax is responsible for approximately 84 % of reported cases. In the absence of a vaccine, control strategies are based on the management of cases through rapid diagnosis and adequate treatment, in addition to vector control measures. The approaches used to investigate P. vivax resistance to chloroquine (CQ) were exclusively in vivo studies because of the difficulty in keeping parasites in continuous in vitro culture. In view of the limitations related to follow-up of patients and to assessing the plasma dosage of CQ and its metabolites, an alternative approach to monitor chemo-resistance (QR) is to use molecular markers. Single nucleotide polymorphisms (SNPs) in the multidrug resistance gene pvmdr1 are putative determinants of CQ resistance (CQR), but such SNPs in P. vivax isolates from patients with good response to treatment should be further explored. The aim of this study is to investigate the mutations in the gene, supposedly associated to QR, in P. vivax isolates from successfully cured patients, living in Brazilian endemic and non-endemic areas.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16573/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALlarissa2_gomes_etal_IOC_2016.pdflarissa2_gomes_etal_IOC_2016.pdfapplication/pdf1019673https://www.arca.fiocruz.br/bitstream/icict/16573/2/larissa2_gomes_etal_IOC_2016.pdf37afb1dafa313ef83407b071d6b5f1c3MD52TEXTlarissa2_gomes_etal_IOC_2016.pdf.txtlarissa2_gomes_etal_IOC_2016.pdf.txtExtracted texttext/plain28089https://www.arca.fiocruz.br/bitstream/icict/16573/3/larissa2_gomes_etal_IOC_2016.pdf.txt602221c2d99aa981c75a4a10d1a93c39MD53icict/165732023-10-25 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dc.title.pt_BR.fl_str_mv Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
title Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
spellingShingle Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
Gomes, Larissa Rodrigues
Plasmodium vivax
Resistência à cloroquina
Brasil
Plasmodium vivax
Chloroquine resistance
Pvmdr1 gene
Brazil
title_short Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
title_full Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
title_fullStr Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
title_full_unstemmed Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
title_sort Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non-endemic Brazilian areas
author Gomes, Larissa Rodrigues
author_facet Gomes, Larissa Rodrigues
Oliveira, Natália Ketrin Almeida de
Lavigne, Aline Rosa de
Lima, Suelen Rezende Félix de
Costa, Anielle de Pina
Brasil, Patrícia
Daniel-Ribeiro, Cláudio Tadeu
Ménard, Didier
Cruz, Maria de Fátima Ferreira da
author_role author
author2 Oliveira, Natália Ketrin Almeida de
Lavigne, Aline Rosa de
Lima, Suelen Rezende Félix de
Costa, Anielle de Pina
Brasil, Patrícia
Daniel-Ribeiro, Cláudio Tadeu
Ménard, Didier
Cruz, Maria de Fátima Ferreira da
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gomes, Larissa Rodrigues
Oliveira, Natália Ketrin Almeida de
Lavigne, Aline Rosa de
Lima, Suelen Rezende Félix de
Costa, Anielle de Pina
Brasil, Patrícia
Daniel-Ribeiro, Cláudio Tadeu
Ménard, Didier
Cruz, Maria de Fátima Ferreira da
dc.subject.other.pt_BR.fl_str_mv Plasmodium vivax
Resistência à cloroquina
Brasil
topic Plasmodium vivax
Resistência à cloroquina
Brasil
Plasmodium vivax
Chloroquine resistance
Pvmdr1 gene
Brazil
dc.subject.en.pt_BR.fl_str_mv Plasmodium vivax
Chloroquine resistance
Pvmdr1 gene
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ. Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Centro de Pesquisa, Diagnóstico e Tratamento em Malária (CPD-Mal). Rio de Janeiro, RJ, Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-27T12:44:02Z
dc.date.available.fl_str_mv 2016-12-27T12:44:02Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GOMES, Larissa Rodrigues et al. Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non‑endemic Brazilian areas. Malaria Journal, v. 15, n. 96, p. 1-5, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16573
dc.identifier.issn.pt_BR.fl_str_mv 1475-2875
dc.identifier.doi.none.fl_str_mv 10.1186/s12936-016-1141-9
identifier_str_mv GOMES, Larissa Rodrigues et al. Plasmodium vivax mdr1 genotypes in isolates from successfully cured patients living in endemic and non‑endemic Brazilian areas. Malaria Journal, v. 15, n. 96, p. 1-5, 2016.
1475-2875
10.1186/s12936-016-1141-9
url https://www.arca.fiocruz.br/handle/icict/16573
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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