Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks

Detalhes bibliográficos
Autor(a) principal: Riccio, Evelyn K. P.
Data de Publicação: 2003
Outros Autores: Júnior, Ivan Neves, Riccio, Lilian R. Pratt, Alecrim, Maria das Graças, Corte-Real, Suzana, Morgado, Mariza, Daniel-Ribeiro, Cláudio T., Ferreira-da-Cruz, Maria de Fátima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1007/s00436-002-0816-z
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33619
Resumo: Ivan Neves Júnior. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Riccio, Evelyn K. P.Júnior, Ivan NevesRiccio, Lilian R. PrattAlecrim, Maria das GraçasCorte-Real, SuzanaMorgado, MarizaDaniel-Ribeiro, Cláudio T.Ferreira-da-Cruz, Maria de Fátima2019-06-21T14:00:33Z2019-06-21T14:00:33Z2003RICCIO, Evelyn K.P. et al. Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks. Parasitology Research, v. 90, n. 1, p. 9-18, 2003.0932-0113https://www.arca.fiocruz.br/handle/icict/3361910.1007/s00436-002-0816-z1432-1955Ivan Neves Júnior. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2020-06-21Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação de Medicina Tropical. Manaus, AM, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultra-Estrutura e Biologia Celular. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia, Laboratório de Pesquisas em Malária. Rio de Janeiro, RJ, Brasil.The occurrence and intensity of lymphocyte apoptosis in blood samples from 79 outclinic patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria and 30 healthy individuals were investigated. No difference in apoptosis percentages was detected between healthy individuals and malaria patients when ex vivo lymphocytes were analyzed. However, significantly increased apoptosis levels were observed in lymphocytes from both P. falciparum- and P. vivax-infected patients when the cells were cultured for 24 h. CD4(+)and CD8(+) T cells were affected to a comparable extent in P.falciparum- and P.vivax-infected patients. However, when we compared apoptosis values in infected and non-infected individuals it appeared that CD4(+) T cells were more susceptible than CD8(+) T cells. A significant increase in the sIL-2R plasma levels was observed in malaria patients when compared with healthy individuals and a positive correlation was observed between sIL-2R levels and apoptosis rates in infected patients presenting increased rates of apoptosis. An increased expression of Fas antigen was recorded after stimulation with P. falciparum antigen or anti-CD3 monoclonal antibody. These data show that a consistent proportion of the lymphocyte population dies by apoptosis during a malaria infection and that a period of time is necessary before in vivo activated cells can express the apoptotic process in vitro.engSpringer VerlagMalaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacksinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMalariaApoptosisinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
title Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
spellingShingle Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
Riccio, Evelyn K. P.
Malaria
Apoptosis
title_short Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
title_full Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
title_fullStr Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
title_full_unstemmed Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
title_sort Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks
author Riccio, Evelyn K. P.
author_facet Riccio, Evelyn K. P.
Júnior, Ivan Neves
Riccio, Lilian R. Pratt
Alecrim, Maria das Graças
Corte-Real, Suzana
Morgado, Mariza
Daniel-Ribeiro, Cláudio T.
Ferreira-da-Cruz, Maria de Fátima
author_role author
author2 Júnior, Ivan Neves
Riccio, Lilian R. Pratt
Alecrim, Maria das Graças
Corte-Real, Suzana
Morgado, Mariza
Daniel-Ribeiro, Cláudio T.
Ferreira-da-Cruz, Maria de Fátima
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Riccio, Evelyn K. P.
Júnior, Ivan Neves
Riccio, Lilian R. Pratt
Alecrim, Maria das Graças
Corte-Real, Suzana
Morgado, Mariza
Daniel-Ribeiro, Cláudio T.
Ferreira-da-Cruz, Maria de Fátima
dc.subject.en.pt_BR.fl_str_mv Malaria
Apoptosis
topic Malaria
Apoptosis
description Ivan Neves Júnior. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2019-06-21T14:00:33Z
dc.date.available.fl_str_mv 2019-06-21T14:00:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv RICCIO, Evelyn K.P. et al. Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks. Parasitology Research, v. 90, n. 1, p. 9-18, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33619
dc.identifier.issn.pt_BR.fl_str_mv 0932-0113
dc.identifier.doi.none.fl_str_mv 10.1007/s00436-002-0816-z
dc.identifier.eissn.none.fl_str_mv 1432-1955
identifier_str_mv RICCIO, Evelyn K.P. et al. Malaria associated apoptosis is not significantly correlated with either parasitemia or the number of previous malaria attacks. Parasitology Research, v. 90, n. 1, p. 9-18, 2003.
0932-0113
10.1007/s00436-002-0816-z
1432-1955
url https://www.arca.fiocruz.br/handle/icict/33619
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33619/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33619/2/ve_Riccio_Evelyn_etal_INI_2003.pdf
https://www.arca.fiocruz.br/bitstream/icict/33619/3/ve_Riccio_Evelyn_etal_INI_2003.pdf.txt
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