Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis

Detalhes bibliográficos
Autor(a) principal: Charret, Karen S.
Data de Publicação: 2009
Outros Autores: Rodrigues, Raquel F., Bernardino, Alice M. R., Gomes, Adriana O., Carvalho, Adriana V., Canto-Cavalheiro, Marilene M., Leon, Leonor L., Amaral, Veronica F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31098
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.
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spelling Charret, Karen S.Rodrigues, Raquel F.Bernardino, Alice M. R.Gomes, Adriana O.Carvalho, Adriana V.Canto-Cavalheiro, Marilene M.Leon, Leonor L.Amaral, Veronica F.2019-01-17T12:14:15Z2019-01-17T12:14:15Z2009CHARRET, Karen S. et al. Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis. Am. J. Trop. Med. Hyg., v.80, n.4, p.568-573, 2009.0002-9637https://www.arca.fiocruz.br/handle/icict/310981476-1645engAmerican Society of Tropical Medicine and HygieneLeishmania amazonensistratamento oralInfecção murinaDerivados de pirazoleto-carbohydrazideOral treatmentPyrazole Carbohydrazide DerivativesMurine infectionLeishmania amazonensisEffect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Programa de Pós-graduação em Química Orgânica.Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Química. Departamento de Química Orgânica. Programa de Pós-graduação em Química Orgânica. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunobiologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunobiologia. Niterói, RJ, Brasil.Newly synthesized pyrazole carbohydrazide derivatives with substituents X = Br/Y = NO 2 and X = NO 2 /Y = Cl were independently investigated in the CBA mouse model of cutaneous leishmaniasis. Animals were infected with Leishmania amazonensis and treated two weeks after the parasitic infection with the pyrazole carbohydrazides for 45 days. Oral treatment with both compounds controlled evolution of footpad cutaneous lesions and dissemination of parasites to draining lymph nodes. Nitric oxide generation was observed in supernatants of lymph node cells from infected CBA mice that were treated with these compounds. The pyrazole carbohydrazide derivatives did not show any toxicity or cause alterations in body weight, plasma concentrations of alanine aminotransferase and aspartate aminotransferase, and urinary creatinine levels, but promoted a small decrease in blood neutrophils. These results provide new perspectives on the development of drugs with activities against leishmaniasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31098/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALleonorleon_mcavalheiro_etal_IOC_2009.pdfleonorleon_mcavalheiro_etal_IOC_2009.pdfapplication/pdf541312https://www.arca.fiocruz.br/bitstream/icict/31098/2/leonorleon_mcavalheiro_etal_IOC_2009.pdfc2b3e1d8c16cf14103c53d7f86d33740MD52TEXTleonorleon_mcavalheiro_etal_IOC_2009.pdf.txtleonorleon_mcavalheiro_etal_IOC_2009.pdf.txtExtracted texttext/plain37897https://www.arca.fiocruz.br/bitstream/icict/31098/3/leonorleon_mcavalheiro_etal_IOC_2009.pdf.txt322380df1dacb157a70e9d082c50ef6bMD53icict/310982019-01-18 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dc.title.pt_BR.fl_str_mv Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
title Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
spellingShingle Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
Charret, Karen S.
Leishmania amazonensis
tratamento oral
Infecção murina
Derivados de pirazoleto-carbohydrazide
Oral treatment
Pyrazole Carbohydrazide Derivatives
Murine infection
Leishmania amazonensis
title_short Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
title_full Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
title_fullStr Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
title_full_unstemmed Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
title_sort Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis
author Charret, Karen S.
author_facet Charret, Karen S.
Rodrigues, Raquel F.
Bernardino, Alice M. R.
Gomes, Adriana O.
Carvalho, Adriana V.
Canto-Cavalheiro, Marilene M.
Leon, Leonor L.
Amaral, Veronica F.
author_role author
author2 Rodrigues, Raquel F.
Bernardino, Alice M. R.
Gomes, Adriana O.
Carvalho, Adriana V.
Canto-Cavalheiro, Marilene M.
Leon, Leonor L.
Amaral, Veronica F.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Charret, Karen S.
Rodrigues, Raquel F.
Bernardino, Alice M. R.
Gomes, Adriana O.
Carvalho, Adriana V.
Canto-Cavalheiro, Marilene M.
Leon, Leonor L.
Amaral, Veronica F.
dc.subject.other.pt_BR.fl_str_mv Leishmania amazonensis
tratamento oral
Infecção murina
Derivados de pirazoleto-carbohydrazide
topic Leishmania amazonensis
tratamento oral
Infecção murina
Derivados de pirazoleto-carbohydrazide
Oral treatment
Pyrazole Carbohydrazide Derivatives
Murine infection
Leishmania amazonensis
dc.subject.en.pt_BR.fl_str_mv Oral treatment
Pyrazole Carbohydrazide Derivatives
Murine infection
Leishmania amazonensis
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica de Tripanosomatídeos. Rio de Janeiro, RJ, Brasil.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2019-01-17T12:14:15Z
dc.date.available.fl_str_mv 2019-01-17T12:14:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHARRET, Karen S. et al. Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis. Am. J. Trop. Med. Hyg., v.80, n.4, p.568-573, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31098
dc.identifier.issn.pt_BR.fl_str_mv 0002-9637
dc.identifier.eissn.none.fl_str_mv 1476-1645
identifier_str_mv CHARRET, Karen S. et al. Effect of Oral Treatment with Pyrazole Carbohydrazide Derivatives against Murine Infection by Leishmania amazonensis. Am. J. Trop. Med. Hyg., v.80, n.4, p.568-573, 2009.
0002-9637
1476-1645
url https://www.arca.fiocruz.br/handle/icict/31098
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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