Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/16427 |
Resumo: | CNPq contract grant (#620219/2008-4) provided by the Brazilian Minister for Health (FIOCRUZ). |
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Gonçalves, Rozana OliveiraFraga, Lucas RosaSantos, Wendell Vilas BoasCarvalho, Acácia Fernandes Lacerda deCerqueira, Bruno Antonio VelosoSarno, Manoel Alfredo CurveloToralles, Maria Betania PVieira, M JDutra, C GSchüler-Faccini, LavíniaSanseverino, Maria Teresa VieiraGonçalves, Marilda de SouzaVianna, Fernanda Sales LuizCosta, Olivia Lucia Nunes2016-12-05T18:45:10Z2016-12-05T18:45:10Z2016GONÇALVES, R. O. et. al. Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women. Genetics and Molecular Research, v. 15, n. 3, p. gmr.15038156, 2016.1676-5680https://www.arca.fiocruz.br/handle/icict/1642710.4238/gmr.15038156CNPq contract grant (#620219/2008-4) provided by the Brazilian Minister for Health (FIOCRUZ).Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, BrasilUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, Brasil / Hospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, BrasilHospital de Clínicas de Porto Alegre. Serviço de Genética Médica. Porto Alegre, RS, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Hematologia, Genética e Biologia Computacional. Salvador, BA, BrasilUniversidade Federal do Rio Grande do Sul. Programa de Pós-Graduação em Genética e Biologia Molecular. Porto Alegre, RS, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilSome cases of recurrent first trimester miscarriage have a thrombotic etiology. The aim of this study was to investigate the prevalence of the most common thrombophilic mutations - factor V (FV) Leiden G1691A (FVL), prothrombin (FII) G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T - in women with recurrent miscarriages. In this case-control study, we included 137 women with two or more consecutive first-trimester miscarriages (£12 weeks of gestation) and 100 healthy women with no history of pregnancy loss, and with at least one living child. DNA was extracted from the patient samples, and the relevant genes (FVL, FII, and MTHFR) were amplified by PCR, followed by restriction fragment length polymorphism, to assess the polymorphisms in these genes. The allelic frequencies of polymorphisms were not significantly different between the case and control groups. Polymorphisms in the MTHFR, FVL, and FII genes were not associated with recurrent miscarriage during the first trimester of pregnancy in Brazilian women (P = 0.479; P = 0.491 and P = 0.107, respectively). However, the etiologic identification of genetic factors is important for genetic counseling.engFundação Norte-Rio-Grandense de Pesquisa e CulturaAbortoProtrombinaPolimorfismoTromboseHumanosFemininoAconselhamento genéticoRecurrent miscarriageFirst trimester miscarriageFactor V LeidenMethylenetetrahydrofolate reductase C677TFII G20210AAssociation between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian womeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/16427/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGonçalves RO Association between....pdfGonçalves RO Association 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| dc.title.pt_BR.fl_str_mv |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| title |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| spellingShingle |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women Gonçalves, Rozana Oliveira Aborto Protrombina Polimorfismo Trombose Humanos Feminino Aconselhamento genético Recurrent miscarriage First trimester miscarriage Factor V Leiden Methylenetetrahydrofolate reductase C677T FII G20210A |
| title_short |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| title_full |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| title_fullStr |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| title_full_unstemmed |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| title_sort |
Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women |
| author |
Gonçalves, Rozana Oliveira |
| author_facet |
Gonçalves, Rozana Oliveira Fraga, Lucas Rosa Santos, Wendell Vilas Boas Carvalho, Acácia Fernandes Lacerda de Cerqueira, Bruno Antonio Veloso Sarno, Manoel Alfredo Curvelo Toralles, Maria Betania P Vieira, M J Dutra, C G Schüler-Faccini, Lavínia Sanseverino, Maria Teresa Vieira Gonçalves, Marilda de Souza Vianna, Fernanda Sales Luiz Costa, Olivia Lucia Nunes |
| author_role |
author |
| author2 |
Fraga, Lucas Rosa Santos, Wendell Vilas Boas Carvalho, Acácia Fernandes Lacerda de Cerqueira, Bruno Antonio Veloso Sarno, Manoel Alfredo Curvelo Toralles, Maria Betania P Vieira, M J Dutra, C G Schüler-Faccini, Lavínia Sanseverino, Maria Teresa Vieira Gonçalves, Marilda de Souza Vianna, Fernanda Sales Luiz Costa, Olivia Lucia Nunes |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gonçalves, Rozana Oliveira Fraga, Lucas Rosa Santos, Wendell Vilas Boas Carvalho, Acácia Fernandes Lacerda de Cerqueira, Bruno Antonio Veloso Sarno, Manoel Alfredo Curvelo Toralles, Maria Betania P Vieira, M J Dutra, C G Schüler-Faccini, Lavínia Sanseverino, Maria Teresa Vieira Gonçalves, Marilda de Souza Vianna, Fernanda Sales Luiz Costa, Olivia Lucia Nunes |
| dc.subject.other.pt_BR.fl_str_mv |
Aborto Protrombina Polimorfismo Trombose Humanos Feminino Aconselhamento genético |
| topic |
Aborto Protrombina Polimorfismo Trombose Humanos Feminino Aconselhamento genético Recurrent miscarriage First trimester miscarriage Factor V Leiden Methylenetetrahydrofolate reductase C677T FII G20210A |
| dc.subject.en.pt_BR.fl_str_mv |
Recurrent miscarriage First trimester miscarriage Factor V Leiden Methylenetetrahydrofolate reductase C677T FII G20210A |
| description |
CNPq contract grant (#620219/2008-4) provided by the Brazilian Minister for Health (FIOCRUZ). |
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2016 |
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2016-12-05T18:45:10Z |
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2016-12-05T18:45:10Z |
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2016 |
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info:eu-repo/semantics/article |
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GONÇALVES, R. O. et. al. Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women. Genetics and Molecular Research, v. 15, n. 3, p. gmr.15038156, 2016. |
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https://www.arca.fiocruz.br/handle/icict/16427 |
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1676-5680 |
| dc.identifier.doi.none.fl_str_mv |
10.4238/gmr.15038156 |
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GONÇALVES, R. O. et. al. Association between the thrombophilic polymorphisms MTHFR C677T, Factor V Leiden, and prothrombin G20210A and recurrent miscarriage in Brazilian women. Genetics and Molecular Research, v. 15, n. 3, p. gmr.15038156, 2016. 1676-5680 10.4238/gmr.15038156 |
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Fundação Norte-Rio-Grandense de Pesquisa e Cultura |
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Fundação Norte-Rio-Grandense de Pesquisa e Cultura |
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