Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant

Detalhes bibliográficos
Autor(a) principal: Mesquita, Milene
Data de Publicação: 2014
Outros Autores: Resende, Paola, Marttorelli, Andressa, Machado, Viviane, Sacramento, Carolina Q., Rodrigues, Natalia Fintelman, Abrantes, Juliana L., Tavares, Rita, Schirmer, Marcelo, Siqueira, Marilda Agudo Mendonça Teixeira de, Souza, Thiago Moreno L
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10827
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.
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spelling Mesquita, MileneResende, PaolaMarttorelli, AndressaMachado, VivianeSacramento, Carolina Q.Rodrigues, Natalia FintelmanAbrantes, Juliana L.Tavares, RitaSchirmer, MarceloSiqueira, Marilda Agudo Mendonça Teixeira deSouza, Thiago Moreno L2015-06-12T13:57:53Z2015-06-12T13:57:53Z2014MESQUITA, Milene et al. Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant. Plos One, v.9, n.4, 6p., 2014.https://www.arca.fiocruz.br/handle/icict/1082710.1371/journal.pone.0094822engPlos OneDetection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplantinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer (INCA). Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Instituto Nacional de Câncer (INCA). Centro de Transplante de Medula Óssea. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.The 2009 pandemic influenza A(H1N1)pdm09 virus emerged and caused considerable morbidity and mortality in the third world, especially in Brazil. Although circulating strains of A(H1N1)pdm09 are A/California/04/2009-like (CA-04-like) viruses, various studies have suggested that some mutations in the viral hemagglutinin (HA) may be associated with enhanced severity and fatality. This phenomenon is particularly challenging for immunocompromised individuals, such as those who have undergone bone marrow transplant (BMT), because they are more likely to display worse clinical outcomes to influenza infection than non-immunocompromised individuals. We studied the clinical and viral aspects of post-BMT patients with confirmed A(H1N1)pdm09 diagnosis in the largest cancer hospital in Brazil. We found a viral strain with K-15E, P83S and Q293H polymorphisms in the HA, which is presumably more virulent, in these individuals. Despite that, these patients showed only mild symptoms of infection. Our findings complement the discovery of mild cases of infection with the A(H1N1)pdm09 virus with the K-15E, P83S and Q293H mutations in Brazil and oppose other studies that have linked these changes with increased disease severity. These results could be important for a better comprehension of the impact of the pandemic influenza in the context of BMT.Influenza A(H1N1)Bone Marrow TransplantInfluenza A virusTransplanteMedula ósseaVírus da Influenza Ainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/10827/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALpaola_resendeetal_IOC-2014.pdfapplication/pdf491610https://www.arca.fiocruz.br/bitstream/icict/10827/2/paola_resendeetal_IOC-2014.pdf6032ccfb6d14d8d8e446e5111663c990MD52TEXTpaola_resendeetal_IOC-2014.pdf.txtpaola_resendeetal_IOC-2014.pdf.txtExtracted texttext/plain29707https://www.arca.fiocruz.br/bitstream/icict/10827/3/paola_resendeetal_IOC-2014.pdf.txt90cc745c368defa007524d78c648686dMD53icict/108272022-06-24 13:08:45.723oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
title Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
spellingShingle Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
Mesquita, Milene
Influenza A(H1N1)
Bone Marrow Transplant
Influenza A virus
Transplante
Medula óssea
Vírus da Influenza A
title_short Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
title_full Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
title_fullStr Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
title_full_unstemmed Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
title_sort Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant
author Mesquita, Milene
author_facet Mesquita, Milene
Resende, Paola
Marttorelli, Andressa
Machado, Viviane
Sacramento, Carolina Q.
Rodrigues, Natalia Fintelman
Abrantes, Juliana L.
Tavares, Rita
Schirmer, Marcelo
Siqueira, Marilda Agudo Mendonça Teixeira de
Souza, Thiago Moreno L
author_role author
author2 Resende, Paola
Marttorelli, Andressa
Machado, Viviane
Sacramento, Carolina Q.
Rodrigues, Natalia Fintelman
Abrantes, Juliana L.
Tavares, Rita
Schirmer, Marcelo
Siqueira, Marilda Agudo Mendonça Teixeira de
Souza, Thiago Moreno L
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Mesquita, Milene
Resende, Paola
Marttorelli, Andressa
Machado, Viviane
Sacramento, Carolina Q.
Rodrigues, Natalia Fintelman
Abrantes, Juliana L.
Tavares, Rita
Schirmer, Marcelo
Siqueira, Marilda Agudo Mendonça Teixeira de
Souza, Thiago Moreno L
dc.subject.en.pt_BR.fl_str_mv Influenza A(H1N1)
Bone Marrow Transplant
Influenza A virus
topic Influenza A(H1N1)
Bone Marrow Transplant
Influenza A virus
Transplante
Medula óssea
Vírus da Influenza A
dc.subject.decs.pt_BR.fl_str_mv Transplante
Medula óssea
Vírus da Influenza A
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. WHO/NIC. Laboratório de Vírus Respiratório e Sarampo. Rio de Janeiro, RJ, Brasil.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-12T13:57:53Z
dc.date.available.fl_str_mv 2015-06-12T13:57:53Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MESQUITA, Milene et al. Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant. Plos One, v.9, n.4, 6p., 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10827
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pone.0094822
identifier_str_mv MESQUITA, Milene et al. Detection of the Influenza A(H1N1)pdm09 Virus Carrying the K-15E, P83S and Q293H Mutations in Patients Who Have Undergone Bone Marrow Transplant. Plos One, v.9, n.4, 6p., 2014.
10.1371/journal.pone.0094822
url https://www.arca.fiocruz.br/handle/icict/10827
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Plos One
publisher.none.fl_str_mv Plos One
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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