Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis

Detalhes bibliográficos
Autor(a) principal: Aleixo, Ana Luisa Quintella do Couto
Data de Publicação: 2019
Outros Autores: Oliveira, Raquel Vasconcelos C. de, Albuquerque, Maíra Cavalcanti, Biancardi, Ana Luiza, Curi, André Luiz Land, Benchimol, Eliezer Israel, Amendoeira, Maria Regina Reis
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1371/journal.pone.0211627
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32311
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.
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spelling Aleixo, Ana Luisa Quintella do CoutoOliveira, Raquel Vasconcelos C. deAlbuquerque, Maíra CavalcantiBiancardi, Ana LuizaCuri, André Luiz LandBenchimol, Eliezer IsraelAmendoeira, Maria Regina Reis2019-04-01T14:01:19Z2019-04-01T14:01:19Z2019ALEIXO, Ana Luisa Quintella do Couto et al. Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis. Plos One, p. 1-8, Feb. 12, 2019.1932-6203https://www.arca.fiocruz.br/handle/icict/3231110.1371/journal.pone.02116271932-6203engPublic Library of ScienceToxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Purpose: To analyze risk factors for recurrent toxoplasmic retinochoroiditis. Design: Single center prospective case series. Population and Methods: A total of 230 patients with toxoplasmic retinochoroiditis were prospectively followed to assess recurrences. All patients were treated with a specific drug regime for toxoplasmosis in each episode of active retinochoroiditis. Individuals with chronic diseases and pregnant women were excluded. Survival analysis by extended Cox regression model (Prentice-Williams-Peterson counting process model) was performed to evaluate the time between recurrences according to some potential risk factors: age, number of retinochoroidal lesions at initial evaluation, sex and interferon gamma +874 T/A gene polymorphism. Hazard Ratios (HR) and 95% confidence intervals (CI) were provided to interpret the risk effects. Results: One hundred sixty-two recurrence episodes were observed in 104 (45.2%) patients during follow-up that lasted from 269 to 1976 days. Mean age at presentation was 32.8 years (Standard deviation = 11.38). The risk of recurrence during follow up was influenced by age (HR = 1.02, 95% CI = 1.01–1.04) and number of retinochoroidal lesions at the beginning of Purpose To analyze risk factors for recurrent toxoplasmic retinochoroiditis. Design: Single center prospective case series. Population and Methods: A total of 230 patients with toxoplasmic retinochoroiditis were prospectively followed to assess recurrences. All patients were treated with a specific drug regime for toxoplasmosis in each episode of active retinochoroiditis. Individuals with chronic diseases and pregnant women were excluded. Survival analysis by extended Cox regression model (Prentice-Williams-Peterson counting process model) was performed to evaluate the time between recurrences according to some potential risk factors: age, number of retinochoroidal lesions at initial evaluation, sex and interferon gamma +874 T/A gene polymorphism. Hazard Ratios (HR) and 95% confidence intervals (CI) were provided to interpret the risk effects. Results: One hundred sixty-two recurrence episodes were observed in 104 (45.2%) patients during follow-up that lasted from 269 to 1976 days. Mean age at presentation was 32.8 years (Standard deviation = 11.38). The risk of recurrence during follow up was influenced by age (HR = 1.02, 95% CI = 1.01–1.04) and number of retinochoroidal lesions at the beginning of the study (HR = 1.60, 95% CI = 1.07–2.40). Heterozygosis for IFN-γ gene polymorphism at position +874 T/A was also associated with recurrence (HR = 1.49, 95% CI = 1.04–2.14). Conclusion: The risk of ocular toxoplasmosis recurrence after an active episode increased with age and was significantly higher in individuals with primary lesions, which suggests that individuals with this characteristic and the elderly could benefit from recurrence prophylactic strategies with antimicrobials. Results suggest an association between IFN-γ gene polymorphism at position +874T/A and recurrence.ToxoplasmosisToxoplasmic retinochoroiditisRetinochoroidal lesionsGenetic polymorphismIFN-γ +874 T/Ainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32311/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Aleixo_Ana_Luisa_etal_INI_2019.pdfve_Aleixo_Ana_Luisa_etal_INI_2019.pdfapplication/pdf380558https://www.arca.fiocruz.br/bitstream/icict/32311/2/ve_Aleixo_Ana_Luisa_etal_INI_2019.pdfc9798b284c5d46a4da8851e7f1f749beMD52TEXTve_Aleixo_Ana_Luisa_etal_INI_2019.pdf.txtve_Aleixo_Ana_Luisa_etal_INI_2019.pdf.txtExtracted texttext/plain29125https://www.arca.fiocruz.br/bitstream/icict/32311/3/ve_Aleixo_Ana_Luisa_etal_INI_2019.pdf.txt2672186356c829a34acae171c2d86cadMD53icict/323112023-09-05 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dc.title.pt_BR.fl_str_mv Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
title Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
spellingShingle Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
Aleixo, Ana Luisa Quintella do Couto
Toxoplasmosis
Toxoplasmic retinochoroiditis
Retinochoroidal lesions
Genetic polymorphism
IFN-γ +874 T/A
title_short Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
title_full Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
title_fullStr Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
title_full_unstemmed Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
title_sort Toxoplasmic retinochoroiditis: the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis
author Aleixo, Ana Luisa Quintella do Couto
author_facet Aleixo, Ana Luisa Quintella do Couto
Oliveira, Raquel Vasconcelos C. de
Albuquerque, Maíra Cavalcanti
Biancardi, Ana Luiza
Curi, André Luiz Land
Benchimol, Eliezer Israel
Amendoeira, Maria Regina Reis
author_role author
author2 Oliveira, Raquel Vasconcelos C. de
Albuquerque, Maíra Cavalcanti
Biancardi, Ana Luiza
Curi, André Luiz Land
Benchimol, Eliezer Israel
Amendoeira, Maria Regina Reis
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Aleixo, Ana Luisa Quintella do Couto
Oliveira, Raquel Vasconcelos C. de
Albuquerque, Maíra Cavalcanti
Biancardi, Ana Luiza
Curi, André Luiz Land
Benchimol, Eliezer Israel
Amendoeira, Maria Regina Reis
dc.subject.en.pt_BR.fl_str_mv Toxoplasmosis
Toxoplasmic retinochoroiditis
Retinochoroidal lesions
Genetic polymorphism
IFN-γ +874 T/A
topic Toxoplasmosis
Toxoplasmic retinochoroiditis
Retinochoroidal lesions
Genetic polymorphism
IFN-γ +874 T/A
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa. Rio de Janeiro, RJ, Brasil.
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-04-01T14:01:19Z
dc.date.available.fl_str_mv 2019-04-01T14:01:19Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ALEIXO, Ana Luisa Quintella do Couto et al. Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis. Plos One, p. 1-8, Feb. 12, 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32311
dc.identifier.issn.pt_BR.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0211627
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv ALEIXO, Ana Luisa Quintella do Couto et al. Toxoplasmic retinochoroiditis: The influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-γ +874 T/A as risk factors for recurrence in a survival analysis. Plos One, p. 1-8, Feb. 12, 2019.
1932-6203
10.1371/journal.pone.0211627
url https://www.arca.fiocruz.br/handle/icict/32311
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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