HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?

Detalhes bibliográficos
Autor(a) principal: Sarno, Euzenir Nunes
Data de Publicação: 2008
Outros Autores: Illarramendi Rojas, Ximena, Nery, José A. Costa, Sales, Ana M., Gutierrez-Galhardo, Maria C., Penna, Maria L. Fernandes, Sampaio, Elizabeth Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/32018
Resumo: 2022-01-01
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spelling Sarno, Euzenir NunesIllarramendi Rojas, XimenaNery, José A. CostaSales, Ana M.Gutierrez-Galhardo, Maria C.Penna, Maria L. FernandesSampaio, Elizabeth Pereira2019-03-09T18:34:05Z2019-03-09T18:34:05Z2008SARNO, Euzenir Nunes et al. HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy? Public Health Reports, v. 123, p. 206-212, mar./abr. 2008.0033-3549https://www.arca.fiocruz.br/handle/icict/3201810.1177/0033354908123002131468-2877engSAGE PublicationsHanseníaseHIVMycobacterium lepraeTratamento antiretroviralLeprosyMycobacterium lepraeHIVAntiretroviral treatmentHIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2022-01-01Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Departamento de Infectologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Medicina Social. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ, BrasilIt has been speculated that, as seen in tuberculosis, human immunodeficiency virus (HIV) and Mycobacterium leprae (M. leprae) co-infection may exacerbate the pathogenesis of leprosy lesions and/or lead to increased susceptibility to leprosy. However, to date, HIV infection has not appeared to increase susceptibility to leprosy. In contrast, initiation of antiretroviral treatment (ART) has been reported to be associated with anecdotal activation of M. leprae infection and exacerbation of existing leprosy lesions. To determine whether ART is associated with worsening of the manifestations of leprosy, a cohort of leprosy patients recruited between 1996 and 2006 at the Oswaldo Cruz Foundation (FIOCRUZ) Leprosy Outpatient Clinic in Rio de Janeiro, Brazil, was studied longitudinally. ART treatment of HIV/leprosy co-infection was associated with the tuberculoid type, paucibacillary disease, and lower bacillary loads. CD4 lymphocyte counts were higher among HIV/ leprosy patients at the time of leprosy diagnosis, while viral loads were lower compared with the time of HIV diagnosis. The conclusion was that ART and immune reconstitution were critical factors driving the development and/or clinical appearance of leprosy lesions.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/32018/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALximena_ilarramendi_etal_IOC_2008.pdfximena_ilarramendi_etal_IOC_2008.pdfapplication/pdf110984https://www.arca.fiocruz.br/bitstream/icict/32018/2/ximena_ilarramendi_etal_IOC_2008.pdfcaf6b7bdc6f72542645ed631bff8122bMD52TEXTximena_ilarramendi_etal_IOC_2008.pdf.txtximena_ilarramendi_etal_IOC_2008.pdf.txtExtracted texttext/plain28474https://www.arca.fiocruz.br/bitstream/icict/32018/3/ximena_ilarramendi_etal_IOC_2008.pdf.txta423b717ffad247ce1e856d591454b55MD53icict/320182023-04-22 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dc.title.pt_BR.fl_str_mv HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
title HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
spellingShingle HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
Sarno, Euzenir Nunes
Hanseníase
HIV
Mycobacterium leprae
Tratamento antiretroviral
Leprosy
Mycobacterium leprae
HIV
Antiretroviral treatment
title_short HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
title_full HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
title_fullStr HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
title_full_unstemmed HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
title_sort HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy?
author Sarno, Euzenir Nunes
author_facet Sarno, Euzenir Nunes
Illarramendi Rojas, Ximena
Nery, José A. Costa
Sales, Ana M.
Gutierrez-Galhardo, Maria C.
Penna, Maria L. Fernandes
Sampaio, Elizabeth Pereira
author_role author
author2 Illarramendi Rojas, Ximena
Nery, José A. Costa
Sales, Ana M.
Gutierrez-Galhardo, Maria C.
Penna, Maria L. Fernandes
Sampaio, Elizabeth Pereira
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sarno, Euzenir Nunes
Illarramendi Rojas, Ximena
Nery, José A. Costa
Sales, Ana M.
Gutierrez-Galhardo, Maria C.
Penna, Maria L. Fernandes
Sampaio, Elizabeth Pereira
dc.subject.other.pt_BR.fl_str_mv Hanseníase
HIV
Mycobacterium leprae
Tratamento antiretroviral
topic Hanseníase
HIV
Mycobacterium leprae
Tratamento antiretroviral
Leprosy
Mycobacterium leprae
HIV
Antiretroviral treatment
dc.subject.en.pt_BR.fl_str_mv Leprosy
Mycobacterium leprae
HIV
Antiretroviral treatment
description 2022-01-01
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2019-03-09T18:34:05Z
dc.date.available.fl_str_mv 2019-03-09T18:34:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv SARNO, Euzenir Nunes et al. HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy? Public Health Reports, v. 123, p. 206-212, mar./abr. 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/32018
dc.identifier.issn.pt_BR.fl_str_mv 0033-3549
dc.identifier.doi.pt_BR.fl_str_mv 10.1177/003335490812300213
dc.identifier.eissn.none.fl_str_mv 1468-2877
identifier_str_mv SARNO, Euzenir Nunes et al. HIV-M. Leprae Interaction: Can HAART Modify the Course of Leprosy? Public Health Reports, v. 123, p. 206-212, mar./abr. 2008.
0033-3549
10.1177/003335490812300213
1468-2877
url https://www.arca.fiocruz.br/handle/icict/32018
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SAGE Publications
publisher.none.fl_str_mv SAGE Publications
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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