Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da Universidade Federal do Ceará (UFC) |
Texto Completo: | http://www.repositorio.ufc.br/handle/riufc/26499 |
Resumo: | Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae. |
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Repositório Institucional da Universidade Federal do Ceará (UFC) |
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Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of ageHanseníaseLeprosyMycobacterium lepraeConsidering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae.Brazilian Journal of Infectious Diseases2017-10-09T14:37:49Z2017-10-09T14:37:49Z2017-09info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfMACEDO, A. C. de et al. Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age. Brazilian Journal of Infectious Diseases, Salvador, v. 21, n. 5, p. 551-561, set./oct. 2017.(Online) 1678-4391(Impresso) 1413-8670http://www.repositorio.ufc.br/handle/riufc/26499Macedo, Alexandre Casimiro deCunha Júnior, José EvandroYaochite, Juliana Navarro UedaTavares, Clodis MariaNagao-Dias, Aparecida Tiemiengreponame:Repositório Institucional da Universidade Federal do Ceará (UFC)instname:Universidade Federal do Ceará (UFC)instacron:UFCinfo:eu-repo/semantics/openAccess2022-03-30T18:14:22Zoai:repositorio.ufc.br:riufc/26499Repositório InstitucionalPUBhttp://www.repositorio.ufc.br/ri-oai/requestbu@ufc.br || repositorio@ufc.bropendoar:2024-09-11T18:31:23.028018Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC)false |
dc.title.none.fl_str_mv |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
title |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
spellingShingle |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age Macedo, Alexandre Casimiro de Hanseníase Leprosy Mycobacterium leprae |
title_short |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
title_full |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
title_fullStr |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
title_full_unstemmed |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
title_sort |
Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age |
author |
Macedo, Alexandre Casimiro de |
author_facet |
Macedo, Alexandre Casimiro de Cunha Júnior, José Evandro Yaochite, Juliana Navarro Ueda Tavares, Clodis Maria Nagao-Dias, Aparecida Tiemi |
author_role |
author |
author2 |
Cunha Júnior, José Evandro Yaochite, Juliana Navarro Ueda Tavares, Clodis Maria Nagao-Dias, Aparecida Tiemi |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Macedo, Alexandre Casimiro de Cunha Júnior, José Evandro Yaochite, Juliana Navarro Ueda Tavares, Clodis Maria Nagao-Dias, Aparecida Tiemi |
dc.subject.por.fl_str_mv |
Hanseníase Leprosy Mycobacterium leprae |
topic |
Hanseníase Leprosy Mycobacterium leprae |
description |
Considering that the main route of Mycobacterium leprae transmission is the upper respiratory tract, detection of salivary antibodies can be a useful tool for diagnosing early infection. The study aimed to analyze salivary anti-PGL-1 IgA and IgM antibodies in 169 children aged 4–16 years old, who lived nearby or inside the house of multibacillary or paucibacillary leprosy patients in two endemic cities in Alagoas State – Brazil. Salivary anti-PGL-1 antibodies were quantified by modified ELISA method. The frequency of contact and clinical form of the index case were significantly associated with salivary antibody levels. High frequency of IgM positivity strongly suggests active transmission of M. leprae in these communities. We suggest in the present work that salivary anti-PGL IgA and IgM are important biomarkers to be used for identifying communities with probable active transmission of M. leprae. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-09T14:37:49Z 2017-10-09T14:37:49Z 2017-09 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
MACEDO, A. C. de et al. Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age. Brazilian Journal of Infectious Diseases, Salvador, v. 21, n. 5, p. 551-561, set./oct. 2017. (Online) 1678-4391 (Impresso) 1413-8670 http://www.repositorio.ufc.br/handle/riufc/26499 |
identifier_str_mv |
MACEDO, A. C. de et al. Salivary anti-PGL-1 IgM may indicate active transmission of Mycobacterium leprae among young people under 16 years of age. Brazilian Journal of Infectious Diseases, Salvador, v. 21, n. 5, p. 551-561, set./oct. 2017. (Online) 1678-4391 (Impresso) 1413-8670 |
url |
http://www.repositorio.ufc.br/handle/riufc/26499 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
publisher.none.fl_str_mv |
Brazilian Journal of Infectious Diseases |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da Universidade Federal do Ceará (UFC) instname:Universidade Federal do Ceará (UFC) instacron:UFC |
instname_str |
Universidade Federal do Ceará (UFC) |
instacron_str |
UFC |
institution |
UFC |
reponame_str |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
collection |
Repositório Institucional da Universidade Federal do Ceará (UFC) |
repository.name.fl_str_mv |
Repositório Institucional da Universidade Federal do Ceará (UFC) - Universidade Federal do Ceará (UFC) |
repository.mail.fl_str_mv |
bu@ufc.br || repositorio@ufc.br |
_version_ |
1813028839489536000 |