The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren

Detalhes bibliográficos
Autor(a) principal: Oliveira, Gabriel Melo de
Data de Publicação: 2020
Outros Autores: Rossi, Maria Inês Doria
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42205
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Oliveira, Gabriel Melo deRossi, Maria Inês Doria2020-07-10T19:07:56Z2020-07-10T19:07:56Z2020OLIVEIRA, Gabriel Melo de; ROSSI, Maria Inês Doria. The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren. Nephrology and Renal Diseases, v. 5, p. 1-5, May 2020.2399-908Xhttps://www.arca.fiocruz.br/handle/icict/4220510.15761/NRD.1000165engScholars CentralCOVID-19Pacientes hipertensosManejoInfecçãoUso de AliskirenCOVID-19Possible managementHypertensive patientsInfectionUse of AliskirenThe possible management of hypertensive patients infected with COVID-19 through the use of Aliskireninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil.In late 2019, a novel corona virus (COVID-19) was identified in Wuhan, a city in the Hubei province of China. COVID-19 rapidly spread and led to an outbreak in China and then became a global health emergency. Human pathogenic coronavirus bind to their target cells through angiotensin-converting enzyme 2 (ACE2). The expression of ACE2 is substantially increased in hypertension patients and with type 1 or type 2 diabetes. Hypertension is also treated with ACE inhibitors and ARBs, which results in an upregulation of ACE2.We therefore hypothesis that hypertension and diabetes treatment with ACE2-stimulating drugs increases the risk of developing severe and fatal COVID-19. Therefore, we propose for COVID-19 patients to prevent ANG I and II formation by direct blockade of renin with the specific inhibitor called Aliskiren. The aliskiren acts as a renin inhibitor, which blocks the conversion of angiotensinogen to ANG I. Hence, blood pressure is reduce by decreasing the amount of ANG II to reach the AT1 receptor, thereby causing a decrease ACE2 released. Through the respective review, we hope to contribute to the treatment of patients infected with COVID-19, especially hypertensive patients.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42205/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALGabrielMOliveira_MariaIDRossi_IOC_2020.pdfGabrielMOliveira_MariaIDRossi_IOC_2020.pdfapplication/pdf290249https://www.arca.fiocruz.br/bitstream/icict/42205/2/GabrielMOliveira_MariaIDRossi_IOC_2020.pdfcd5b9175ab5452ba29f571f3e8eea6bdMD52TEXTGabrielMOliveira_MariaIDRossi_IOC_2020.pdf.txtGabrielMOliveira_MariaIDRossi_IOC_2020.pdf.txtExtracted texttext/plain32233https://www.arca.fiocruz.br/bitstream/icict/42205/3/GabrielMOliveira_MariaIDRossi_IOC_2020.pdf.txt3f0655e51d3859438f3f74832af62bccMD53icict/422052020-07-11 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dc.title.pt_BR.fl_str_mv The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
title The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
spellingShingle The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
Oliveira, Gabriel Melo de
COVID-19
Pacientes hipertensos
Manejo
Infecção
Uso de Aliskiren
COVID-19
Possible management
Hypertensive patients
Infection
Use of Aliskiren
title_short The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
title_full The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
title_fullStr The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
title_full_unstemmed The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
title_sort The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren
author Oliveira, Gabriel Melo de
author_facet Oliveira, Gabriel Melo de
Rossi, Maria Inês Doria
author_role author
author2 Rossi, Maria Inês Doria
author2_role author
dc.contributor.author.fl_str_mv Oliveira, Gabriel Melo de
Rossi, Maria Inês Doria
dc.subject.other.pt_BR.fl_str_mv COVID-19
Pacientes hipertensos
Manejo
Infecção
Uso de Aliskiren
topic COVID-19
Pacientes hipertensos
Manejo
Infecção
Uso de Aliskiren
COVID-19
Possible management
Hypertensive patients
Infection
Use of Aliskiren
dc.subject.en.pt_BR.fl_str_mv COVID-19
Possible management
Hypertensive patients
Infection
Use of Aliskiren
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-10T19:07:56Z
dc.date.available.fl_str_mv 2020-07-10T19:07:56Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv OLIVEIRA, Gabriel Melo de; ROSSI, Maria Inês Doria. The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren. Nephrology and Renal Diseases, v. 5, p. 1-5, May 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42205
dc.identifier.issn.pt_BR.fl_str_mv 2399-908X
dc.identifier.doi.none.fl_str_mv 10.15761/NRD.1000165
identifier_str_mv OLIVEIRA, Gabriel Melo de; ROSSI, Maria Inês Doria. The possible management of hypertensive patients infected with COVID-19 through the use of Aliskiren. Nephrology and Renal Diseases, v. 5, p. 1-5, May 2020.
2399-908X
10.15761/NRD.1000165
url https://www.arca.fiocruz.br/handle/icict/42205
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Scholars Central
publisher.none.fl_str_mv Scholars Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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