Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets

Detalhes bibliográficos
Autor(a) principal: Wrasse-Sangoi,Micheli
Data de Publicação: 2010
Outros Autores: Secretti,Leonardo Trevisan, Diefenbach,Isabel Fração, Rolim,Clarice Madalena Bueno, Sangoi,Maximiliano da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Química Nova (Online)
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600021
Resumo: For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r² = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05).
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spelling Development and validation of an UV spectrophotometric method for the determination of aliskiren in tabletsaliskirenpharmaceutical formulationUV spectrophotometryFor determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r² = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05).Sociedade Brasileira de Química2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600021Química Nova v.33 n.6 2010reponame:Química Nova (Online)instname:Sociedade Brasileira de Química (SBQ)instacron:SBQ10.1590/S0100-40422010000600021info:eu-repo/semantics/openAccessWrasse-Sangoi,MicheliSecretti,Leonardo TrevisanDiefenbach,Isabel FraçãoRolim,Clarice Madalena BuenoSangoi,Maximiliano da Silvaeng2010-08-24T00:00:00Zoai:scielo:S0100-40422010000600021Revistahttps://www.scielo.br/j/qn/ONGhttps://old.scielo.br/oai/scielo-oai.phpquimicanova@sbq.org.br1678-70640100-4042opendoar:2010-08-24T00:00Química Nova (Online) - Sociedade Brasileira de Química (SBQ)false
dc.title.none.fl_str_mv Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
title Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
spellingShingle Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
Wrasse-Sangoi,Micheli
aliskiren
pharmaceutical formulation
UV spectrophotometry
title_short Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
title_full Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
title_fullStr Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
title_full_unstemmed Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
title_sort Development and validation of an UV spectrophotometric method for the determination of aliskiren in tablets
author Wrasse-Sangoi,Micheli
author_facet Wrasse-Sangoi,Micheli
Secretti,Leonardo Trevisan
Diefenbach,Isabel Fração
Rolim,Clarice Madalena Bueno
Sangoi,Maximiliano da Silva
author_role author
author2 Secretti,Leonardo Trevisan
Diefenbach,Isabel Fração
Rolim,Clarice Madalena Bueno
Sangoi,Maximiliano da Silva
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Wrasse-Sangoi,Micheli
Secretti,Leonardo Trevisan
Diefenbach,Isabel Fração
Rolim,Clarice Madalena Bueno
Sangoi,Maximiliano da Silva
dc.subject.por.fl_str_mv aliskiren
pharmaceutical formulation
UV spectrophotometry
topic aliskiren
pharmaceutical formulation
UV spectrophotometry
description For determination of aliskiren in commercial samples, an analytical UV spectrophotometric method was developed and validate according to ICH guideline. The method was linear in the range between 40 and 100 μg mL-1 (r² = 0.9997, n = 7) and exhibited suitable specificity, accuracy, precision, and robustness. It is simple, it has low cost, and it has low use polluting reagents. Therefore, the proposed method was successfully applied for the assay and dissolution studies of aliskiren in tablet dosage forms, and the results were compared to a validated RP-LC method, showing non-significant difference (P > 0.05).
publishDate 2010
dc.date.none.fl_str_mv 2010-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600021
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422010000600021
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0100-40422010000600021
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Química
publisher.none.fl_str_mv Sociedade Brasileira de Química
dc.source.none.fl_str_mv Química Nova v.33 n.6 2010
reponame:Química Nova (Online)
instname:Sociedade Brasileira de Química (SBQ)
instacron:SBQ
instname_str Sociedade Brasileira de Química (SBQ)
instacron_str SBQ
institution SBQ
reponame_str Química Nova (Online)
collection Química Nova (Online)
repository.name.fl_str_mv Química Nova (Online) - Sociedade Brasileira de Química (SBQ)
repository.mail.fl_str_mv quimicanova@sbq.org.br
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