Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.

Detalhes bibliográficos
Autor(a) principal: Lima, Celio Geraldo Freire de
Data de Publicação: 2000
Outros Autores: Nascimento, Danielle de Oliveira, Soares, Milena Botelho Pereira, Bozza, Patrícia Torres, Faria Neto, Hugo Caire de Castro, Mello, Fernando G. de, DosReis, George Alexandre, Lopes, Marcela de Freitas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/9910
Resumo: Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
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spelling Lima, Celio Geraldo Freire deNascimento, Danielle de OliveiraSoares, Milena Botelho PereiraBozza, Patrícia TorresFaria Neto, Hugo Caire de CastroMello, Fernando G. deDosReis, George AlexandreLopes, Marcela de Freitas2015-04-07T16:30:54Z2015-04-07T16:30:54Z2000Freirde-Lima, C. G. et al. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature, v. 403, n. 6766, p. 199-203, 2000.0028-0836https://www.arca.fiocruz.br/handle/icict/9910engMacmillan Magazines LtdUptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilUniversidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, BrasilAfter apoptosis, phagocytes prevent inflammation and tissue damage by the uptake and removal of dead cells. In addition, apoptotic cells evoke an anti-inflammatory response through macrophages. We have previously shown that there is intense lymphocyte apoptosis in an experimental model of Chagas' disease, a debilitating cardiac illness caused by the protozoan Trypanosoma cruzi. Here we show that the interaction of apoptotic, but not necrotic T lymphocytes with macrophages infected with T. cruzi fuels parasite growth in a manner dependent on prostaglandins, transforming growth factor-beta (TGF-beta) and polyamine biosynthesis. We show that the vitronectin receptor is critical, in both apoptotic-cell cytoadherence and the induction of prostaglandin E2/TGF-beta release and ornithine decarboxylase activity in macrophages. A single injection of apoptotic cells in infected mice increases parasitaemia, whereas treatment with cyclooxygenase inhibitors almost completely ablates it in vivo. These results suggest that continual lymphocyte apoptosis and phagocytosis of apoptotic cells by macrophages have a role in parasite persistence in the host, and that cyclooxygenase inhibitors have potential therapeutic application in the control of parasite replication and spread in Chagas' disease.ApoptoseMacrófagos/parasitologiaLinfócitos T/fisiologiaTrypanosoma cruzi/crescimento & desenvolvimentoClorometilcetonas de Aminoácidos/farmacologiaAnimaisCélulas CultivadasDoença de Chagas/imunologiaInibidores de Cisteína Proteinase/farmacologiaDinoprostona/biossínteseMasculinoCamundongosCamundongos Endogâmicos BALB CNecroseFagocitose/fisiologiaPutrescina/biossínteseReceptores de Vitronectina/metabolismoLinfócitos T/efeitos de drogasFator de Crescimento Transformador beta/fisiologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
title Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
spellingShingle Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
Lima, Celio Geraldo Freire de
Apoptose
Macrófagos/parasitologia
Linfócitos T/fisiologia
Trypanosoma cruzi/crescimento & desenvolvimento
Clorometilcetonas de Aminoácidos/farmacologia
Animais
Células Cultivadas
Doença de Chagas/imunologia
Inibidores de Cisteína Proteinase/farmacologia
Dinoprostona/biossíntese
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Necrose
Fagocitose/fisiologia
Putrescina/biossíntese
Receptores de Vitronectina/metabolismo
Linfócitos T/efeitos de drogas
Fator de Crescimento Transformador beta/fisiologia
title_short Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
title_full Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
title_fullStr Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
title_full_unstemmed Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
title_sort Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages.
author Lima, Celio Geraldo Freire de
author_facet Lima, Celio Geraldo Freire de
Nascimento, Danielle de Oliveira
Soares, Milena Botelho Pereira
Bozza, Patrícia Torres
Faria Neto, Hugo Caire de Castro
Mello, Fernando G. de
DosReis, George Alexandre
Lopes, Marcela de Freitas
author_role author
author2 Nascimento, Danielle de Oliveira
Soares, Milena Botelho Pereira
Bozza, Patrícia Torres
Faria Neto, Hugo Caire de Castro
Mello, Fernando G. de
DosReis, George Alexandre
Lopes, Marcela de Freitas
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lima, Celio Geraldo Freire de
Nascimento, Danielle de Oliveira
Soares, Milena Botelho Pereira
Bozza, Patrícia Torres
Faria Neto, Hugo Caire de Castro
Mello, Fernando G. de
DosReis, George Alexandre
Lopes, Marcela de Freitas
dc.subject.decs.pt_BR.fl_str_mv Apoptose
Macrófagos/parasitologia
Linfócitos T/fisiologia
Trypanosoma cruzi/crescimento & desenvolvimento
Clorometilcetonas de Aminoácidos/farmacologia
Animais
Células Cultivadas
Doença de Chagas/imunologia
Inibidores de Cisteína Proteinase/farmacologia
Dinoprostona/biossíntese
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Necrose
Fagocitose/fisiologia
Putrescina/biossíntese
Receptores de Vitronectina/metabolismo
Linfócitos T/efeitos de drogas
Fator de Crescimento Transformador beta/fisiologia
topic Apoptose
Macrófagos/parasitologia
Linfócitos T/fisiologia
Trypanosoma cruzi/crescimento & desenvolvimento
Clorometilcetonas de Aminoácidos/farmacologia
Animais
Células Cultivadas
Doença de Chagas/imunologia
Inibidores de Cisteína Proteinase/farmacologia
Dinoprostona/biossíntese
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Necrose
Fagocitose/fisiologia
Putrescina/biossíntese
Receptores de Vitronectina/metabolismo
Linfócitos T/efeitos de drogas
Fator de Crescimento Transformador beta/fisiologia
description Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Rio de Janeiro, RJ, Brasil
publishDate 2000
dc.date.issued.fl_str_mv 2000
dc.date.accessioned.fl_str_mv 2015-04-07T16:30:54Z
dc.date.available.fl_str_mv 2015-04-07T16:30:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Freirde-Lima, C. G. et al. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature, v. 403, n. 6766, p. 199-203, 2000.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/9910
dc.identifier.issn.none.fl_str_mv 0028-0836
identifier_str_mv Freirde-Lima, C. G. et al. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Nature, v. 403, n. 6766, p. 199-203, 2000.
0028-0836
url https://www.arca.fiocruz.br/handle/icict/9910
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Macmillan Magazines Ltd
publisher.none.fl_str_mv Macmillan Magazines Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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