GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/46737 |
Resumo: | Universidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil. |
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Teles, Amanda MaraSilva, João Victor SilvaFernandes, Juan Matheus PereiraSilva, Ana Lucia AbreuCalabrese, Kátia da SilvaMendes Filho, Nestor EvertonMouchrek, Adenilde NascimentoSouza, Fernando Almeida2021-04-16T15:02:59Z2021-04-16T15:02:59Z2021TELES, Amanda Mara et al. GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol. Evidence-Based Complementary and Alternative Medicine, v. 2021, Article ID 666.3255, 12p, Feb. 2021.1741-427Xhttps://www.arca.fiocruz.br/handle/icict/4673710.1155/2021/6663255engHindawiSyzygium aromaticumAtividade antibacterianaAtividade antioxidanteAntitripanossômicaÓleo essencialEugenolCaracterização por GC-MSSyzygium aromaticumAntibacterial activityAntioxidant activityAntitrypanosomal ActivityGC-MS CharacterizationEssential OilEugenolGC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Estadual do Maranhão. Pós-Graduação em Ciência Animal. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil.Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Àgua. São Luis, MA, Brasil.Universidade Federal do Maranhão. Laboratório de Controle de Qualidade de Alimentos e Àgua. São Luis, MA, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil / Universidade Estadual do Maranhão. Pós-Graduação em Ciência Animal. São Luis, MA, Brasil.Syzygium aromaticum has a diversity of biological activities due to the chemical compounds found in its plant products such as total phenolic compounds and flavonoids. The present work describes the chemical analysis and antimicrobial, antioxidant, and antitrypanosomal activity of the essential oil of S. aromaticum. Eugenol (53.23%) as the major compound was verified by gas chromatography-mass spectrometry. S. aromaticum essential oil was more effective against S. aureus (MIC 50 μg/mL) than eugenol (MIC 250 μg/mL). Eugenol presented higher antioxidant activity than S. aromaticum essential oil, with an EC50 of 12.66 and 78.98 µg/mL, respectively. S. aromaticum essential oil and eugenol exhibited Trypanosoma cruzi inhibitory activity, with IC50 of 28.68 ± 1.073 and 31.97 ± 1.061 μg/mL against epimastigotes and IC50 of 64.51 ± 1.658 and 45.73 ± 1.252 μg/mL against intracellular amastigotes, respectively. Both compounds presented low cytotoxicity, with S. aromaticum essential oil displaying 15.5-fold greater selectivity for the parasite than the cells. Nitrite levels in T. cruzi-stimulated cells were reduced by essential oil (47.01%; = 0.002) and eugenol (48.05%; = 0.003) treatment. The trypanocidal activity of S. aromaticum essential oil showed that it is reasonable to use it in future research in the search for new therapeutic alternatives for trypanosomiasis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/46737/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoaoVitorSilva_KatiaCalabrese_etal_IOC_2021.pdfJoaoVitorSilva_KatiaCalabrese_etal_IOC_2021.pdfapplication/pdf2933310https://www.arca.fiocruz.br/bitstream/icict/46737/2/JoaoVitorSilva_KatiaCalabrese_etal_IOC_2021.pdf37e49a5cb5eb201be746503d0057f53aMD52TEXTJoaoVitorSilva_KatiaCalabrese_etal_IOC_2021.pdf.txtJoaoVitorSilva_KatiaCalabrese_etal_IOC_2021.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| title |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| spellingShingle |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol Teles, Amanda Mara Syzygium aromaticum Atividade antibacteriana Atividade antioxidante Antitripanossômica Óleo essencial Eugenol Caracterização por GC-MS Syzygium aromaticum Antibacterial activity Antioxidant activity Antitrypanosomal Activity GC-MS Characterization Essential Oil Eugenol |
| title_short |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| title_full |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| title_fullStr |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| title_full_unstemmed |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| title_sort |
GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol |
| author |
Teles, Amanda Mara |
| author_facet |
Teles, Amanda Mara Silva, João Victor Silva Fernandes, Juan Matheus Pereira Silva, Ana Lucia Abreu Calabrese, Kátia da Silva Mendes Filho, Nestor Everton Mouchrek, Adenilde Nascimento Souza, Fernando Almeida |
| author_role |
author |
| author2 |
Silva, João Victor Silva Fernandes, Juan Matheus Pereira Silva, Ana Lucia Abreu Calabrese, Kátia da Silva Mendes Filho, Nestor Everton Mouchrek, Adenilde Nascimento Souza, Fernando Almeida |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Teles, Amanda Mara Silva, João Victor Silva Fernandes, Juan Matheus Pereira Silva, Ana Lucia Abreu Calabrese, Kátia da Silva Mendes Filho, Nestor Everton Mouchrek, Adenilde Nascimento Souza, Fernando Almeida |
| dc.subject.other.pt_BR.fl_str_mv |
Syzygium aromaticum Atividade antibacteriana Atividade antioxidante Antitripanossômica Óleo essencial Eugenol Caracterização por GC-MS |
| topic |
Syzygium aromaticum Atividade antibacteriana Atividade antioxidante Antitripanossômica Óleo essencial Eugenol Caracterização por GC-MS Syzygium aromaticum Antibacterial activity Antioxidant activity Antitrypanosomal Activity GC-MS Characterization Essential Oil Eugenol |
| dc.subject.en.pt_BR.fl_str_mv |
Syzygium aromaticum Antibacterial activity Antioxidant activity Antitrypanosomal Activity GC-MS Characterization Essential Oil Eugenol |
| description |
Universidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil. |
| publishDate |
2021 |
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2021-04-16T15:02:59Z |
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2021-04-16T15:02:59Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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TELES, Amanda Mara et al. GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol. Evidence-Based Complementary and Alternative Medicine, v. 2021, Article ID 666.3255, 12p, Feb. 2021. |
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https://www.arca.fiocruz.br/handle/icict/46737 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1741-427X |
| dc.identifier.doi.none.fl_str_mv |
10.1155/2021/6663255 |
| identifier_str_mv |
TELES, Amanda Mara et al. GC-MS Characterization of Antibacterial, Antioxidant, and Antitrypanosomal Activity of Syzygium aromaticum Essential Oil and Eugenol. Evidence-Based Complementary and Alternative Medicine, v. 2021, Article ID 666.3255, 12p, Feb. 2021. 1741-427X 10.1155/2021/6663255 |
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https://www.arca.fiocruz.br/handle/icict/46737 |
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Hindawi |
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Hindawi |
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