Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection

Detalhes bibliográficos
Autor(a) principal: Rocha, Iara Caixeta Marques da
Data de Publicação: 2018
Outros Autores: Santos, Letícia Helena Marques Dos, Coura-Vital, Wendel, Cunha, Gisele Macedo Rodrigues da, Magalhães, Fernanda do Carmo, Silva, Thais Almeida Marques da, Morais, Maria Helena Franco, Oliveira, Edward José de, Reis, Ilka Afonso, Carneiro, Mariângela
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/54569
Resumo: FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS
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spelling Rocha, Iara Caixeta Marques daSantos, Letícia Helena Marques DosCoura-Vital, WendelCunha, Gisele Macedo Rodrigues daMagalhães, Fernanda do CarmoSilva, Thais Almeida Marques daMorais, Maria Helena FrancoOliveira, Edward José deReis, Ilka AfonsoCarneiro, Mariângela2022-08-10T17:59:34Z2022-08-10T17:59:34Z2018ROCHA, Iara Caixeta Marques da et al. Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection. Parasit Vectors, v. 11, n. 1, 586, 2018. doi: 10.1186/s13071-018-3166-0.1756-3305https://www.arca.fiocruz.br/handle/icict/5456910.1186/s13071-018-3166-0FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAISUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Secretaria Municipal de Saúde de Belo Horizonte. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Universidade Federal de Ouro Preto. Escola de Farmácia. Departamento de Análises Clínicas. Pós-graduação em Ciências Farmacêuticas. Ouro Preto, MG, Brazil/Universidade Federal de Ouro Preto. Núcleo de Pesquisa em Ciências Biológicas. Pós-graduação em Ciências Biológicas Ouro Preto. Ouro Preto, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/ Santa Casa Belo Horizonte. Instituto de Ensino e Pesquisa. Belo Horizonte, MG, Brazil.Secretaria Municipal de Saúde de Belo Horizonte. Belo Horizonte, MG, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Laboratório de Pesquisas Clínicas. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Exatas. Departamento de Estatística. Belo Horizonte, MG, Brazil.Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Parasitologia. Laboratório de Epidemiologia das Doenças Infecciosas e Parasitárias. Belo Horizonte, MG, Brazil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Pós-graduação em Ciências da Saúde: Infectologia e Medicina Tropical. Belo Horizonte, MG, BrazilBackground: Control strategies adopted by the Brazilian Visceral Leishmaniasis Surveillance and Control Programme (VLSCP) include identifying and culling seropositive infected dogs, early diagnosis and treatment of human cases, chemical control of the vector and population awareness. This study evaluated the effectiveness of the VLSCP on the prevalence and incidence rates of Leishmania infantum in children residing in areas under different VLSCP intervention times. Methods: A quasi-experimental epidemiological study with a panel (two cross-sectional) and a concurrent cohort was performed in three areas of Belo Horizonte, southeast Brazil. The first cross-sectional study (I) was carried out with 1875 children, 478 of which were enrolled in the cohort study. In the second cross-sectional study (II), 413 additional children were included, totalizing 891 children. Laboratory diagnosis was performed by ELISA-rK39. Analyses included multilevel logistic and Poisson regression models. Results: The incidence rates of L. infantum infection were: 14.4% in the area where VLSCP intervention was initiated in 2006 (AI2006); 21.1% in the area where intervention was initiated in 2008 (AI2008); and 11.6% in the area where intervention was initiated in 2010 (AI2010 - control area). A follow-up period of 24 months showed that the persons-time incidence rates in AI2006, AI2008, and AI2010 were: 6.2/100, 10/100, and 5.6/100 persons/24 months, respectively. The final prevalence rates of infection (cross-sectional II - in 2012), compared to the initial rates (cross-sectional I - in 2010), increased 83.7% in AI2006, 74.1% in AI2008, and decreased 5% in AI2010. Analysis of the effectiveness revealed that children residing in AI2008 are more likely to be infected (OR = 1.84; 95% CI: 1.06-3.23) and present a higher risk of infection (IRR = 1.76; 95% CI: 1.05-2.95) compared to those in AI2010. No statistically significant differences were observed in asymptomatic infection (OR and IRR) in AI2006 compared to AI2010. Conclusions: The VLSCP was not effective at controlling L. infantum infection in areas where interventions had respectively been carried out for six and four years. However, it is unclear what the consequences in terms of human infection and diseases would be in the absence of the VLSCP. Efforts to improve the effectiveness of control measures remain a necessary priority.engBioMed CentralEffectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleControl programmeVisceral leishmaniasisEffectivenessLeishmania infantum infectionQuasi-experimental studyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/54569/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALEffectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection.pdfEffectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection.pdfapplication/pdf591767https://www.arca.fiocruz.br/bitstream/icict/54569/2/Effectiveness%20of%20the%20Brazilian%20Visceral%20Leishmaniasis%20Surveillance%20and%20Control%20Programme%20in%20reducing%20the%20prevalence%20and%20incidence%20of%20Leishmania%20infantum%20infection.pdf6bed8c9a9a827f5f489cd026b636b8fcMD52icict/545692022-08-10 14:59:34.674oai:www.arca.fiocruz.br:icict/54569Tk9URTogUExBQ0UgWU9VUiBPV04gTElDRU5TRSBIRVJFClRoaXMgc2FtcGxlIGxpY2Vuc2UgaXMgcHJvdmlkZWQgZm9yIGluZm9ybWF0aW9uYWwgcHVycG9zZXMgb25seS4KCk5PTi1FWENMVVNJVkUgRElTVFJJQlVUSU9OIExJQ0VOU0UKCkJ5IHNpZ25pbmcgYW5kIHN1Ym1pdHRpbmcgdGhpcyBsaWNlbnNlLCB5b3UgKHRoZSBhdXRob3Iocykgb3IgY29weXJpZ2h0Cm93bmVyKSBncmFudHMgdG8gRFNwYWNlIFVuaXZlcnNpdHkgKERTVSkgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgdG8gcmVwcm9kdWNlLAp0cmFuc2xhdGUgKGFzIGRlZmluZWQgYmVsb3cpLCBhbmQvb3IgZGlzdHJpYnV0ZSB5b3VyIHN1Ym1pc3Npb24gKGluY2x1ZGluZwp0aGUgYWJzdHJhY3QpIHdvcmxkd2lkZSBpbiBwcmludCBhbmQgZWxlY3Ryb25pYyBmb3JtYXQgYW5kIGluIGFueSBtZWRpdW0sCmluY2x1ZGluZyBidXQgbm90IGxpbWl0ZWQgdG8gYXVkaW8gb3IgdmlkZW8uCgpZb3UgYWdyZWUgdGhhdCBEU1UgbWF5LCB3aXRob3V0IGNoYW5naW5nIHRoZSBjb250ZW50LCB0cmFuc2xhdGUgdGhlCnN1Ym1pc3Npb24gdG8gYW55IG1lZGl1bSBvciBmb3JtYXQgZm9yIHRoZSBwdXJwb3NlIG9mIHByZXNlcnZhdGlvbi4KCllvdSBhbHNvIGFncmVlIHRoYXQgRFNVIG1heSBrZWVwIG1vcmUgdGhhbiBvbmUgY29weSBvZiB0aGlzIHN1Ym1pc3Npb24gZm9yCnB1cnBvc2VzIG9mIHNlY3VyaXR5LCBiYWNrLXVwIGFuZCBwcmVzZXJ2YXRpb24uCgpZb3UgcmVwcmVzZW50IHRoYXQgdGhlIHN1Ym1pc3Npb24gaXMgeW91ciBvcmlnaW5hbCB3b3JrLCBhbmQgdGhhdCB5b3UgaGF2ZQp0aGUgcmlnaHQgdG8gZ3JhbnQgdGhlIHJpZ2h0cyBjb250YWluZWQgaW4gdGhpcyBsaWNlbnNlLiBZb3UgYWxzbyByZXByZXNlbnQKdGhhdCB5b3VyIHN1Ym1pc3Npb24gZG9lcyBub3QsIHRvIHRoZSBiZXN0IG9mIHlvdXIga25vd2xlZGdlLCBpbmZyaW5nZSB1cG9uCmFueW9uZSdzIGNvcHlyaWdodC4KCklmIHRoZSBzdWJtaXNzaW9uIGNvbnRhaW5zIG1hdGVyaWFsIGZvciB3aGljaCB5b3UgZG8gbm90IGhvbGQgY29weXJpZ2h0LAp5b3UgcmVwcmVzZW50IHRoYXQgeW91IGhhdmUgb2J0YWluZWQgdGhlIHVucmVzdHJpY3RlZCBwZXJtaXNzaW9uIG9mIHRoZQpjb3B5cmlnaHQgb3duZXIgdG8gZ3JhbnQgRFNVIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdApzdWNoIHRoaXJkLXBhcnR5IG93bmVkIG1hdGVyaWFsIGlzIGNsZWFybHkgaWRlbnRpZmllZCBhbmQgYWNrbm93bGVkZ2VkCndpdGhpbiB0aGUgdGV4dCBvciBjb250ZW50IG9mIHRoZSBzdWJtaXNzaW9uLgoKSUYgVEhFIFNVQk1JU1NJT04gSVMgQkFTRUQgVVBPTiBXT1JLIFRIQVQgSEFTIEJFRU4gU1BPTlNPUkVEIE9SIFNVUFBPUlRFRApCWSBBTiBBR0VOQ1kgT1IgT1JHQU5JWkFUSU9OIE9USEVSIFRIQU4gRFNVLCBZT1UgUkVQUkVTRU5UIFRIQVQgWU9VIEhBVkUKRlVMRklMTEVEIEFOWSBSSUdIVCBPRiBSRVZJRVcgT1IgT1RIRVIgT0JMSUdBVElPTlMgUkVRVUlSRUQgQlkgU1VDSApDT05UUkFDVCBPUiBBR1JFRU1FTlQuCgpEU1Ugd2lsbCBjbGVhcmx5IGlkZW50aWZ5IHlvdXIgbmFtZShzKSBhcyB0aGUgYXV0aG9yKHMpIG9yIG93bmVyKHMpIG9mIHRoZQpzdWJtaXNzaW9uLCBhbmQgd2lsbCBub3QgbWFrZSBhbnkgYWx0ZXJhdGlvbiwgb3RoZXIgdGhhbiBhcyBhbGxvd2VkIGJ5IHRoaXMKbGljZW5zZSwgdG8geW91ciBzdWJtaXNzaW9uLgo=Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-08-10T17:59:34Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
title Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
spellingShingle Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
Rocha, Iara Caixeta Marques da
Control programme
Visceral leishmaniasis
Effectiveness
Leishmania infantum infection
Quasi-experimental study
title_short Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
title_full Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
title_fullStr Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
title_full_unstemmed Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
title_sort Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection
author Rocha, Iara Caixeta Marques da
author_facet Rocha, Iara Caixeta Marques da
Santos, Letícia Helena Marques Dos
Coura-Vital, Wendel
Cunha, Gisele Macedo Rodrigues da
Magalhães, Fernanda do Carmo
Silva, Thais Almeida Marques da
Morais, Maria Helena Franco
Oliveira, Edward José de
Reis, Ilka Afonso
Carneiro, Mariângela
author_role author
author2 Santos, Letícia Helena Marques Dos
Coura-Vital, Wendel
Cunha, Gisele Macedo Rodrigues da
Magalhães, Fernanda do Carmo
Silva, Thais Almeida Marques da
Morais, Maria Helena Franco
Oliveira, Edward José de
Reis, Ilka Afonso
Carneiro, Mariângela
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Rocha, Iara Caixeta Marques da
Santos, Letícia Helena Marques Dos
Coura-Vital, Wendel
Cunha, Gisele Macedo Rodrigues da
Magalhães, Fernanda do Carmo
Silva, Thais Almeida Marques da
Morais, Maria Helena Franco
Oliveira, Edward José de
Reis, Ilka Afonso
Carneiro, Mariângela
dc.subject.en.pt_BR.fl_str_mv Control programme
Visceral leishmaniasis
Effectiveness
Leishmania infantum infection
Quasi-experimental study
topic Control programme
Visceral leishmaniasis
Effectiveness
Leishmania infantum infection
Quasi-experimental study
description FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2022-08-10T17:59:34Z
dc.date.available.fl_str_mv 2022-08-10T17:59:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ROCHA, Iara Caixeta Marques da et al. Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection. Parasit Vectors, v. 11, n. 1, 586, 2018. doi: 10.1186/s13071-018-3166-0.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/54569
dc.identifier.issn.pt_BR.fl_str_mv 1756-3305
dc.identifier.doi.none.fl_str_mv 10.1186/s13071-018-3166-0
identifier_str_mv ROCHA, Iara Caixeta Marques da et al. Effectiveness of the Brazilian Visceral Leishmaniasis Surveillance and Control Programme in reducing the prevalence and incidence of Leishmania infantum infection. Parasit Vectors, v. 11, n. 1, 586, 2018. doi: 10.1186/s13071-018-3166-0.
1756-3305
10.1186/s13071-018-3166-0
url https://www.arca.fiocruz.br/handle/icict/54569
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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