Phylodynamics of HIV-1 subtype C epidemic in east Africa
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/15811 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
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Delatorre, Edson OliveiraBello, Gonzalo2016-09-15T14:45:28Z2016-09-15T14:45:28Z2012DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012.1932-6203https://www.arca.fiocruz.br/handle/icict/1581110.1371/journal.pone.0041904engPublic Library of ScienceInfecções por HIVAfrica OrientalHIV-1 subtipo CHIV-1 subtype CEast AfricaHIV infectionsPhylodynamics of HIV-1 subtype C epidemic in east Africainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.The HIV-1 subtype C accounts for an important fraction of HIV infections in east Africa, but little is known about the genetic characteristics and evolutionary history of this epidemic. Here we reconstruct the origin and spatiotemporal dynamics of the major HIV-1 subtype C clades circulating in east Africa. A large number (n = 1,981) of subtype C pol sequences were retrieved from public databases to explore relationships between strains from the east, southern and central African regions. Maximum-likelihood phylogenetic analysis of those sequences revealed that most (>70%) strains from east Africa segregated in a single regional-specific monophyletic group, here called C(EA). A second major Ethiopian subtype C lineage and a large collection of minor Kenyan and Tanzanian subtype C clades of southern African origin were also detected. A bayesian coalescent-based method was then used to reconstruct evolutionary parameters and migration pathways of the C(EA) African lineage. This analysis indicates that the C(EA) clade most probably originated in Burundi around the early 1960s, and later spread to Ethiopia, Kenya, Tanzania and Uganda, giving rise to major country-specific monophyletic sub-clusters between the early 1970s and early 1980s. The results presented here demonstrate that a substantial proportion of subtype C infections in east Africa resulted from dissemination of a single HIV local variant, probably originated in Burundi during the 1960s. Burundi was the most important hub of dissemination of that subtype C clade in east Africa, fueling the origin of new local epidemics in Ethiopia, Kenya, Tanzania and Uganda. Subtype C lineages of southern African origin have also been introduced in east Africa, but seem to have had a much more restricted spread.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/15811/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALedson_delatorreebello_IOC_2012.pdfedson_delatorreebello_IOC_2012.pdfapplication/pdf1030944https://www.arca.fiocruz.br/bitstream/icict/15811/2/edson_delatorreebello_IOC_2012.pdf9901530757e5bf1d446c31e2cc7d928aMD52TEXTedson_delatorreebello_IOC_2012.pdf.txtedson_delatorreebello_IOC_2012.pdf.txtExtracted texttext/plain46510https://www.arca.fiocruz.br/bitstream/icict/15811/3/edson_delatorreebello_IOC_2012.pdf.txt1770e675fff1ee729993c68465c4bfedMD53icict/158112018-04-02 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dc.title.pt_BR.fl_str_mv |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
title |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
spellingShingle |
Phylodynamics of HIV-1 subtype C epidemic in east Africa Delatorre, Edson Oliveira Infecções por HIV Africa Oriental HIV-1 subtipo C HIV-1 subtype C East Africa HIV infections |
title_short |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
title_full |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
title_fullStr |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
title_full_unstemmed |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
title_sort |
Phylodynamics of HIV-1 subtype C epidemic in east Africa |
author |
Delatorre, Edson Oliveira |
author_facet |
Delatorre, Edson Oliveira Bello, Gonzalo |
author_role |
author |
author2 |
Bello, Gonzalo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Delatorre, Edson Oliveira Bello, Gonzalo |
dc.subject.other.pt_BR.fl_str_mv |
Infecções por HIV Africa Oriental HIV-1 subtipo C |
topic |
Infecções por HIV Africa Oriental HIV-1 subtipo C HIV-1 subtype C East Africa HIV infections |
dc.subject.en.pt_BR.fl_str_mv |
HIV-1 subtype C East Africa HIV infections |
description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil. |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2016-09-15T14:45:28Z |
dc.date.available.fl_str_mv |
2016-09-15T14:45:28Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/15811 |
dc.identifier.issn.pt_BR.fl_str_mv |
1932-6203 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0041904 |
identifier_str_mv |
DELATORRE, Edson Oliveira; BELLO, Gonzalo. Phylodynamics of HIV-1 Subtype C Epidemic in East Africa. Plos One, v.7, n.7, e42904. 10p, July 2012. 1932-6203 10.1371/journal.pone.0041904 |
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https://www.arca.fiocruz.br/handle/icict/15811 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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