The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review

Detalhes bibliográficos
Autor(a) principal: Moreira, José
Data de Publicação: 2015
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/31535
Resumo: Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Hospital Evandro Chagas, Rio de Janeiro, RJ, Brasil.
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spelling Moreira, José2019-02-11T13:20:28Z2019-02-11T13:20:28Z2015MOREIRA, José. The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review. Brazilian Journal of Infectious Diseases, v. 19, n. 1, p. 77-81, 2015.1413-8670https://www.arca.fiocruz.br/handle/icict/3153510.1016/j.bjid.2014.05.0101678-4391engElsevierThe burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Hospital Evandro Chagas, Rio de Janeiro, RJ, Brasil.Since the advent of highly active antiretroviral therapy in 1996, we have seen dramatic changes in morbi-mortality rates from human immunodeficiency virus-positive patients. If on the one hand, the immunologic preservation-associated with the use of current antiretroviral therapy markedly diminishes the incidence of opportunistic infections, on the other hand it extended life expectancy of human immunodeficiency virus-infected individuals similarly to the general population. However, the management of critically ill human immunodeficiency virus-infected patients remains challenging and troublesome for practicing clinician. Sepsis - a complex systemic inflammatory syndrome in response to infection - is the second leading cause of intensive care unit admission in both human immunodeficiency virus-infected and uninfected populations. Recent data have emerged describing a substantial burden of sepsis in the infected population, in addition, to a much poorer prognosis in this group. Many factors contribute to this outcome, including specific etiologies, patterns of inflammation, underlying immune dysregulation related to chronic human immunodeficiency virus infection and delays in prompt diagnosis and treatment. This brief review explores the impact of sepsis in the context of human immunodeficiency virus infection, and proposes future directions for better management and prevention of human immunodeficiency virus-associated sepsis.SepsisHIVHighly active antiretroviral therapyIntensive careinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31535/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Moreira_José_INI_2015.pdfve_Moreira_José_INI_2015.pdfapplication/pdf674887https://www.arca.fiocruz.br/bitstream/icict/31535/2/ve_Moreira_Jos%c3%a9_INI_2015.pdf578fcfd5f3a62e47825fde3dc4308aaeMD52TEXTve_Moreira_José_INI_2015.pdf.txtve_Moreira_José_INI_2015.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
title The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
spellingShingle The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
Moreira, José
Sepsis
HIV
Highly active antiretroviral therapy
Intensive care
title_short The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
title_full The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
title_fullStr The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
title_full_unstemmed The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
title_sort The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review
author Moreira, José
author_facet Moreira, José
author_role author
dc.contributor.author.fl_str_mv Moreira, José
dc.subject.en.pt_BR.fl_str_mv Sepsis
HIV
Highly active antiretroviral therapy
Intensive care
topic Sepsis
HIV
Highly active antiretroviral therapy
Intensive care
description Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Hospital Evandro Chagas, Rio de Janeiro, RJ, Brasil.
publishDate 2015
dc.date.issued.fl_str_mv 2015
dc.date.accessioned.fl_str_mv 2019-02-11T13:20:28Z
dc.date.available.fl_str_mv 2019-02-11T13:20:28Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MOREIRA, José. The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review. Brazilian Journal of Infectious Diseases, v. 19, n. 1, p. 77-81, 2015.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/31535
dc.identifier.issn.pt_BR.fl_str_mv 1413-8670
dc.identifier.doi.none.fl_str_mv 10.1016/j.bjid.2014.05.010
dc.identifier.eissn.none.fl_str_mv 1678-4391
identifier_str_mv MOREIRA, José. The burden of sepsis in critically ill human immunodeficiency virus-infected patients: a brief review. Brazilian Journal of Infectious Diseases, v. 19, n. 1, p. 77-81, 2015.
1413-8670
10.1016/j.bjid.2014.05.010
1678-4391
url https://www.arca.fiocruz.br/handle/icict/31535
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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