Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26813 |
Resumo: | National Council for Scientific and Technological Development (CNPq, Brazil), grant number: 4768572011-2. |
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Dantas, Rebeca Carolina MoraesSouza, Renata Oliveira deValverde, Ludmila de FaroVidal, Manuela Torres AndionSales, Caroline Brandi SchlaepferSousa, Letícia PalmeiraSantos, Jean Nunes dosRamos, Eduardo Antônio GonçalvesRocha, Clarissa Araújo Gurgel2018-06-11T18:59:13Z2018-06-11T18:59:13Z2017DANTAS, R. C. M. et al. Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 25, n. 10, p. e83-e88, 2017.1541-2016https://www.arca.fiocruz.br/handle/icict/26813National Council for Scientific and Technological Development (CNPq, Brazil), grant number: 4768572011-2.University of Bahia. School of Dentistry. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversity of Bahia. Institute of Health Science. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversity of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / University of Bahia. School of Dentistry of the Federal. Laboratory of Oral Surgical Pathology. Salvador, BA, BrazilThe objective of this study was to compare mast cell density (MCD) in oral epithelial dysplasias (OED) and oral squamous cell carcinoma (OSCC) and determine its correlation with clinical and histopathologic parameters and the degree of tumor differentiation. Thirty OSCC samples, 14 OED samples, and 4 non-neoplastic oral mucosa samples were analyzed by immunohistochemistry to determineMCD based on the expression of MC tryptase. In addition, MCs were categorized morphologically into degranulated and granulated cells. MCD was significantly higher in OSCC lesions with a greater degree of differentiation (P=0.04). No significant difference inMCD was detected between mild and moderate OED samples (P=0.09). Our findings indicate that MCs are present in the tumor microenvironment and may be associated with a better prognosisengLippincott, Williams & WilkinsMastocitomaCarcinoma oral de células escamosasDisplasia epitelial oralDensidade de mastócitosTriptase de mastócitosMast cellOral squamous cell carcinomaOral epithelial dysplasia,Mast cell densityMast cell tryptaseEvaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinomainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26813/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALDantas RCM Evaluation of mast...2017.pdfDantas RCM Evaluation of 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| dc.title.pt_BR.fl_str_mv |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| title |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| spellingShingle |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma Dantas, Rebeca Carolina Moraes Mastocitoma Carcinoma oral de células escamosas Displasia epitelial oral Densidade de mastócitos Triptase de mastócitos Mast cell Oral squamous cell carcinoma Oral epithelial dysplasia, Mast cell density Mast cell tryptase |
| title_short |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| title_full |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| title_fullStr |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| title_full_unstemmed |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| title_sort |
Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma |
| author |
Dantas, Rebeca Carolina Moraes |
| author_facet |
Dantas, Rebeca Carolina Moraes Souza, Renata Oliveira de Valverde, Ludmila de Faro Vidal, Manuela Torres Andion Sales, Caroline Brandi Schlaepfer Sousa, Letícia Palmeira Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| author_role |
author |
| author2 |
Souza, Renata Oliveira de Valverde, Ludmila de Faro Vidal, Manuela Torres Andion Sales, Caroline Brandi Schlaepfer Sousa, Letícia Palmeira Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Dantas, Rebeca Carolina Moraes Souza, Renata Oliveira de Valverde, Ludmila de Faro Vidal, Manuela Torres Andion Sales, Caroline Brandi Schlaepfer Sousa, Letícia Palmeira Santos, Jean Nunes dos Ramos, Eduardo Antônio Gonçalves Rocha, Clarissa Araújo Gurgel |
| dc.subject.other.pt_BR.fl_str_mv |
Mastocitoma Carcinoma oral de células escamosas Displasia epitelial oral Densidade de mastócitos Triptase de mastócitos |
| topic |
Mastocitoma Carcinoma oral de células escamosas Displasia epitelial oral Densidade de mastócitos Triptase de mastócitos Mast cell Oral squamous cell carcinoma Oral epithelial dysplasia, Mast cell density Mast cell tryptase |
| dc.subject.en.pt_BR.fl_str_mv |
Mast cell Oral squamous cell carcinoma Oral epithelial dysplasia, Mast cell density Mast cell tryptase |
| description |
National Council for Scientific and Technological Development (CNPq, Brazil), grant number: 4768572011-2. |
| publishDate |
2017 |
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2017 |
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2018-06-11T18:59:13Z |
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2018-06-11T18:59:13Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
DANTAS, R. C. M. et al. Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 25, n. 10, p. e83-e88, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/26813 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1541-2016 |
| identifier_str_mv |
DANTAS, R. C. M. et al. Evaluation of Mast Cell Density in the Tumor Microenvironment in Oral Epithelial Dysplasia and Oral Squamous Cell Carcinoma. Applied Immunohistochemistry and Molecular Morphology, v. 25, n. 10, p. e83-e88, 2017. 1541-2016 |
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Lippincott, Williams & Wilkins |
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Lippincott, Williams & Wilkins |
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