Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2

Detalhes bibliográficos
Autor(a) principal: Matos, Natália Alves de
Data de Publicação: 2013
Outros Autores: Silva, Josiane Fernandes da, Matsui, Tamires Cardoso, Damasceno, Karine Araujo, Duarte, Igor Dimitri Gama, Lemos, Virgínia Soares, Cassali, Geovanni D, Klein, André
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/26877
Resumo: Damasceno, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Matos, Natália Alves deSilva, Josiane Fernandes daMatsui, Tamires CardosoDamasceno, Karine AraujoDuarte, Igor Dimitri GamaLemos, Virgínia SoaresCassali, Geovanni DKlein, André2018-06-13T17:32:32Z2018-06-13T17:32:32Z2013Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 20360-3997https://www.arca.fiocruz.br/handle/icict/2687710.1007/s10753-013-9664-5Damasceno, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Conselho Nacional de Pesquisa e Desenvolvimento (CNPq/Brazil), Fundação de Amparo à Pesquisa de Minas Gerais (FAPEMIG/Brazil) and CAPES/Brazil.Universidade Federal de Minas Gerais. Departamento de Farmacologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Farmacologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Patologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Farmacologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Fisiologia e Biofísica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Patologia Geral. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Departamento de Farmacologia. Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Farmacologia. Belo Horizonte, MG, BrasilProteinase-activated receptor (PAR) 2 has been implicated in eosinophil migration. Mast cell (MC) tryptase has been similarly implicated in allergic diseases through the activation of PAR-2, but the role of this receptor in MC tryptase-induced inflammation is not well elucidated. This study aims to investigate the ability of MC tryptase or PAR-2 activating peptide (SLIGRL-NH2) to induce eosinophil recruitment to the pleural cavity of mice. Mast cell tryptase-injected mice were pretreated with PAR-2 antagonist ENMD-1068. Mice injected with SLIGRL-NH2 were pretreated with mast cell tryptase inhibitor APC 366, and eosinophil migration into the pleural cavity and PAR-2 expression was analyzed after 24 or 48 h. SLIGRL-NH2-induced eosinophil recruitment was inhibited by APC 366, and MC tryptase-induced eosinophil recruitment was abolished by ENMD-1068. MC tryptase induced PAR-2 expression on pleural eosinophils. Our results demonstrate a key role for PAR-2 in mediating eosinophil recruitment in MC tryptase-induced pleurisy in mice. The ability of MC tryptase to inducing PAR-2 expression on eosinophils corroborates the relevance of MC tryptase and PAR-2 on modulating eosinophil migration.engSpringer VerlagEosinófilosMigração de eosinófilosTriptase de mastócitosPAR-2PleurisiaEosinophilsEosinophil migrationMast cell tryptasePAR-2PleurisyMast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26877/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMatos NA Mast cell....pdfMatos NA Mast cell....pdfapplication/pdf339205https://www.arca.fiocruz.br/bitstream/icict/26877/2/Matos%20NA%20Mast%20cell....pdfb6110350c74cad0922a10500f44e497bMD52TEXTMatos 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dc.title.pt_BR.fl_str_mv Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
title Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
spellingShingle Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
Matos, Natália Alves de
Eosinófilos
Migração de eosinófilos
Triptase de mastócitos
PAR-2
Pleurisia
Eosinophils
Eosinophil migration
Mast cell tryptase
PAR-2
Pleurisy
title_short Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
title_full Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
title_fullStr Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
title_full_unstemmed Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
title_sort Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
author Matos, Natália Alves de
author_facet Matos, Natália Alves de
Silva, Josiane Fernandes da
Matsui, Tamires Cardoso
Damasceno, Karine Araujo
Duarte, Igor Dimitri Gama
Lemos, Virgínia Soares
Cassali, Geovanni D
Klein, André
author_role author
author2 Silva, Josiane Fernandes da
Matsui, Tamires Cardoso
Damasceno, Karine Araujo
Duarte, Igor Dimitri Gama
Lemos, Virgínia Soares
Cassali, Geovanni D
Klein, André
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Matos, Natália Alves de
Silva, Josiane Fernandes da
Matsui, Tamires Cardoso
Damasceno, Karine Araujo
Duarte, Igor Dimitri Gama
Lemos, Virgínia Soares
Cassali, Geovanni D
Klein, André
dc.subject.other.pt_BR.fl_str_mv Eosinófilos
Migração de eosinófilos
Triptase de mastócitos
PAR-2
Pleurisia
topic Eosinófilos
Migração de eosinófilos
Triptase de mastócitos
PAR-2
Pleurisia
Eosinophils
Eosinophil migration
Mast cell tryptase
PAR-2
Pleurisy
dc.subject.en.pt_BR.fl_str_mv Eosinophils
Eosinophil migration
Mast cell tryptase
PAR-2
Pleurisy
description Damasceno, Karine Araújo. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2018-06-13T17:32:32Z
dc.date.available.fl_str_mv 2018-06-13T17:32:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/26877
dc.identifier.issn.pt_BR.fl_str_mv 0360-3997
dc.identifier.doi.none.fl_str_mv 10.1007/s10753-013-9664-5
identifier_str_mv Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2
0360-3997
10.1007/s10753-013-9664-5
url https://www.arca.fiocruz.br/handle/icict/26877
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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