Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2013 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.1590/0037-8682-0064-2012 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/6545 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose |
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Grenfell, Rafaella Fortini QueirozMartins, Watson Mauricio HermanDrummond, Sandra CostaAntunes, Carlos Maurício de FigueiredoVoieta, IzabelaOtoni, AlbaOliveira, Áureo Almeida deMoraes, Vanessa SilvaOliveira, Eduardo Ribeiro deOliveira, Edward José deLambertucci, José RobertoFonseca, Cristina ToscanoCoelho, Paulo Marcos Zach2013-06-03T15:58:30Z2013-06-03T15:58:30Z2013GRENFELL, Rafaella Fortini Queiroz et al. Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma manson.i Rev. Soc. Bras. Med. Trop . 2013, vol.46, n.2, pp. 208-2130037-8682https://www.arca.fiocruz.br/handle/icict/654510.1590/0037-8682-0064-2012engAcute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoniinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Nacional de SaúdeSanta Casa de Misericórdia de Belo HorizonteUniversidade Federal de Minas Gerais. Faculdade de Medicina. Serviço de Doenças Infecciosas e ParasitáriasUniversidade Federal de Minas Gerais. Faculdade de Medicina. Serviço de Doenças Infecciosas e Parasitárias,Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Pesquisas ClínicasUniversidade Federal de Minas Gerais. Faculdade de Medicina. Serviço de Doenças Infecciosas e ParasitáriasFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de EsquistossomoseIntroduction The diagnosis of schistosomiasis mansoni on early stages of infection is important to prevent late morbidity. A simple, cheap, sensitive and specific assay for routine diagnosis of schistosome infection based on the detection of specific IgG for schistosomula tegument antigens (ELISA-SmTeg) was developed by our group. Methods We describe here an acute outbreak involving a travel group of 80 individuals from a non-endemic area of the State of Minas Gerais, Brazil. These individuals were in contact with a freshwater pool where Biomphalaria glabrata was found. Results obtained from our new methodology were compared to IgG antibody titers against soluble worm antigenic preparation (SWAP) by ELISA and, also to parasitological examination, nuclear magnetic resonance and clinical findings. Results ELISA-SmTeg was capable of detecting 64 positive cases among the 80 individuals participating at the survey with a positivity ratio of 80% and a higher sensitivity than ELISA-SWAP that was only sensitive for 56% of positive cases. Besides, a significant correlation was found for the severity of the infection and the specific IgG titers against SmTeg. Conclusions Our data showed that ELISA-SmTeg might serve as the initial diagnostic tool for acute stages of the infection in community-based helminth control programs or for the surveillance of individuals from non-endemic areas.Schistosomiasis mansoniImmunological diagnosisSchistosomula antigensAcute outbreakinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINAL46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdf46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdfapplication/pdf1192741https://www.arca.fiocruz.br/bitstream/icict/6545/1/46%282%292013.indd%20-%200037-8682-rsbmt-46-02-208.pdf.pdf948c10768b93c2aa18baf8fc181468aaMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6545/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXT46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdf.txt46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdf.txtExtracted texttext/plain6https://www.arca.fiocruz.br/bitstream/icict/6545/5/46%282%292013.indd%20-%200037-8682-rsbmt-46-02-208.pdf.pdf.txt6d93d3216dc4a7f5df47d4876fbec4d3MD55THUMBNAIL46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdf.jpg46(2)2013.indd - 0037-8682-rsbmt-46-02-208.pdf.pdf.jpgGenerated Thumbnailimage/jpeg2322https://www.arca.fiocruz.br/bitstream/icict/6545/4/46%282%292013.indd%20-%200037-8682-rsbmt-46-02-208.pdf.pdf.jpg0a5cf77491d1ba8c204e8c88b36d48a8MD54icict/65452018-04-25 14:12:24.668oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-25T17:12:24Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| title |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| spellingShingle |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni Grenfell, Rafaella Fortini Queiroz Schistosomiasis mansoni Immunological diagnosis Schistosomula antigens Acute outbreak |
| title_short |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| title_full |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| title_fullStr |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| title_full_unstemmed |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| title_sort |
Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma mansoni |
| author |
Grenfell, Rafaella Fortini Queiroz |
| author_facet |
Grenfell, Rafaella Fortini Queiroz Martins, Watson Mauricio Herman Drummond, Sandra Costa Antunes, Carlos Maurício de Figueiredo Voieta, Izabela Otoni, Alba Oliveira, Áureo Almeida de Moraes, Vanessa Silva Oliveira, Eduardo Ribeiro de Oliveira, Edward José de Lambertucci, José Roberto Fonseca, Cristina Toscano Coelho, Paulo Marcos Zach |
| author_role |
author |
| author2 |
Martins, Watson Mauricio Herman Drummond, Sandra Costa Antunes, Carlos Maurício de Figueiredo Voieta, Izabela Otoni, Alba Oliveira, Áureo Almeida de Moraes, Vanessa Silva Oliveira, Eduardo Ribeiro de Oliveira, Edward José de Lambertucci, José Roberto Fonseca, Cristina Toscano Coelho, Paulo Marcos Zach |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Grenfell, Rafaella Fortini Queiroz Martins, Watson Mauricio Herman Drummond, Sandra Costa Antunes, Carlos Maurício de Figueiredo Voieta, Izabela Otoni, Alba Oliveira, Áureo Almeida de Moraes, Vanessa Silva Oliveira, Eduardo Ribeiro de Oliveira, Edward José de Lambertucci, José Roberto Fonseca, Cristina Toscano Coelho, Paulo Marcos Zach |
| dc.subject.en.pt_BR.fl_str_mv |
Schistosomiasis mansoni Immunological diagnosis Schistosomula antigens Acute outbreak |
| topic |
Schistosomiasis mansoni Immunological diagnosis Schistosomula antigens Acute outbreak |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Esquistossomose |
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2013 |
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2013-06-03T15:58:30Z |
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2013-06-03T15:58:30Z |
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2013 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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GRENFELL, Rafaella Fortini Queiroz et al. Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma manson.i Rev. Soc. Bras. Med. Trop . 2013, vol.46, n.2, pp. 208-213 |
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https://www.arca.fiocruz.br/handle/icict/6545 |
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0037-8682 |
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10.1590/0037-8682-0064-2012 |
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GRENFELL, Rafaella Fortini Queiroz et al. Acute schistosomiasis diagnosis: a new tool for the diagnosis of schistosomiasis in a group of travelers recently infected in a new focus of Schistosoma manson.i Rev. Soc. Bras. Med. Trop . 2013, vol.46, n.2, pp. 208-213 0037-8682 10.1590/0037-8682-0064-2012 |
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