Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49956 |
Resumo: | Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. |
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Carloto, Amanda Cristina MachadoBortoleti, Bruna Taciane da SilvaRodrigues, Ana Carolina JacobSilva, Taylon FelipeTomiotto-Pellissier, FernandaBidóia, Danielle LazarinGonçalves, Manoela DaieleAssolini, João PauloDekker, Robert F. H.Costa, Idessania NazarethConchon-Costa, IveteMiranda-Sapla, Milena MenegazzoPavanelli, Wander Rogério2021-11-23T13:56:40Z2021-11-23T13:56:40Z2022CARLOTO, Amanda Cristina Machado et al. Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules. Chemico-Biological Interactions. v. 351, n. 109713, p. 1–13, 2022.0009-2797https://www.arca.fiocruz.br/handle/icict/4995610.1016/j.cbi.2021.109713porElsevier. International Society for the Study of XenobioticsBotryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory moleculesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Bahia, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. / Universidade Federal do Paraná. Setor de Ciências da Saúde. Departamento de Patologia Médica, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de londrina. Centro de Ciências Exatas. Departamento de Química. Laboratório de Biotransformação e Fitoquímica. Londrina, PR, Brasil.Universidade Alto Vale do Rio do Peixe. Caçador, SC, Brasil.Universidade Tecnológica Federal do Paraná. Programa de Pós-Graduação em Engenharia Ambiental. Londrina, PR, Brasil. / Beta-Glucan Pharmaceuticals. Londrina, PR, Brasil.Universidade Tecnológica Federal do Paraná. Programa de Pós-Graduação em Engenharia Ambiental. Londrina, PR, Brasil. / Beta-Glucan Pharmaceuticals. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil.Leishmaniasis is an infectious-parasitic disease caused by the protozoan Leishmania spp. The available treatments are based upon expensive drugs bearing adverse side-effects. The search for new therapeutic alternatives that present a more effective action without causing adverse effects to the patient is therefore important. The objective of this study was to evaluate the in vitro effect of botryosphaeran, a (1 → 3)(1 → 6)-β-D-glucan, on the promastigote and intracellular amastigote forms of Leishmania amazonensis. The direct activity of botryosphaeran on promastigote forms was evaluated in vitro and inhibited proliferation, the IC50 7 μg/mL in 48 h was calculated. After 48 h treatment, botryosphaeran induced nitric oxide production (NO), caused mitochondrial membrane hyperpolarization, increased reactive oxygen species (ROS), and accumulation of lipid vesicles in promastigotes, resulting in apoptosis, necrosis and autophagy, and was accompanied by morphological and ultrastructural changes. The range of concentrations used did not alter the viability of peritoneal macrophages from BALB/c mice and erythrocytes of sheep. Botryosphaeran was able to reduce the number of infected macrophages and the number of amastigotes per macrophage at 12.5 μg/mL (50.75% ± 6.48), 25 μg/mL (55.66% ± 3.93) and 50 μg/ mL (72.9% ± 6.98), and IC50 9.3 μg/mL (±0.66) for intracellular amastigotes forms. The leishmanicidal effect was due to activation of NF-κB and promoted an increase in pro-inflammatory cytokines (TNF-α and IL-6), iNOS and microbial-derived ROS and NO, in addition to decreasing the levels of SOD. Based upon the data obtained, we infer that botryosphaeran exerted an active leishmanicidal and immunomodulatory effect, acting on promastigotes through autophagic, apoptotic and necrosis processes, and in the intracellular amastigote form, through the action of ROS and NO.LeishmaniasisCytotoxicity, ImmunologicApoptosisLeishmaniasisCitotoxicidad InmunológicaApoptosisLeishmanioseCytotoxicité immunologiqueApoptoseLeishmanioseCitotoxicidade ImunológicaApoptoseinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/49956/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINAL1-s2.0-S0009279721003513-OK.pdf1-s2.0-S0009279721003513-OK.pdfapplication/pdf9061635https://www.arca.fiocruz.br/bitstream/icict/49956/2/1-s2.0-S0009279721003513-OK.pdf1e375592fd68dc666401477742cd8050MD52icict/499562021-11-23 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| dc.title.pt_BR.fl_str_mv |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| title |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| spellingShingle |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules Carloto, Amanda Cristina Machado Leishmaniasis Cytotoxicity, Immunologic Apoptosis Leishmaniasis Citotoxicidad Inmunológica Apoptosis Leishmaniose Cytotoxicité immunologique Apoptose Leishmaniose Citotoxicidade Imunológica Apoptose |
| title_short |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| title_full |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| title_fullStr |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| title_full_unstemmed |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| title_sort |
Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules |
| author |
Carloto, Amanda Cristina Machado |
| author_facet |
Carloto, Amanda Cristina Machado Bortoleti, Bruna Taciane da Silva Rodrigues, Ana Carolina Jacob Silva, Taylon Felipe Tomiotto-Pellissier, Fernanda Bidóia, Danielle Lazarin Gonçalves, Manoela Daiele Assolini, João Paulo Dekker, Robert F. H. Costa, Idessania Nazareth Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo Pavanelli, Wander Rogério |
| author_role |
author |
| author2 |
Bortoleti, Bruna Taciane da Silva Rodrigues, Ana Carolina Jacob Silva, Taylon Felipe Tomiotto-Pellissier, Fernanda Bidóia, Danielle Lazarin Gonçalves, Manoela Daiele Assolini, João Paulo Dekker, Robert F. H. Costa, Idessania Nazareth Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo Pavanelli, Wander Rogério |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Carloto, Amanda Cristina Machado Bortoleti, Bruna Taciane da Silva Rodrigues, Ana Carolina Jacob Silva, Taylon Felipe Tomiotto-Pellissier, Fernanda Bidóia, Danielle Lazarin Gonçalves, Manoela Daiele Assolini, João Paulo Dekker, Robert F. H. Costa, Idessania Nazareth Conchon-Costa, Ivete Miranda-Sapla, Milena Menegazzo Pavanelli, Wander Rogério |
| dc.subject.en.pt_BR.fl_str_mv |
Leishmaniasis Cytotoxicity, Immunologic Apoptosis |
| topic |
Leishmaniasis Cytotoxicity, Immunologic Apoptosis Leishmaniasis Citotoxicidad Inmunológica Apoptosis Leishmaniose Cytotoxicité immunologique Apoptose Leishmaniose Citotoxicidade Imunológica Apoptose |
| dc.subject.es.pt_BR.fl_str_mv |
Leishmaniasis Citotoxicidad Inmunológica Apoptosis |
| dc.subject.fr.pt_BR.fl_str_mv |
Leishmaniose Cytotoxicité immunologique Apoptose |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Citotoxicidade Imunológica Apoptose |
| description |
Universidade Estadual de Londrina. Centro de Ciências Biológicas. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia de Doenças Negligenciadas e Câncer. Londrina, PR, Brasil. |
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2021 |
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2021-11-23T13:56:40Z |
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2021-11-23T13:56:40Z |
| dc.date.issued.fl_str_mv |
2022 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
CARLOTO, Amanda Cristina Machado et al. Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules. Chemico-Biological Interactions. v. 351, n. 109713, p. 1–13, 2022. |
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https://www.arca.fiocruz.br/handle/icict/49956 |
| dc.identifier.issn.pt_BR.fl_str_mv |
0009-2797 |
| dc.identifier.doi.none.fl_str_mv |
10.1016/j.cbi.2021.109713 |
| identifier_str_mv |
CARLOTO, Amanda Cristina Machado et al. Botryosphaeran, [(1 → 3)(1 → 6)-β-D-glucan], induces apoptosis-like death in promastigotes of Leishmania amazonensis, and exerts a leishmanicidal effect on infected macrophages by activating NF-kB and producing pro-inflammatory molecules. Chemico-Biological Interactions. v. 351, n. 109713, p. 1–13, 2022. 0009-2797 10.1016/j.cbi.2021.109713 |
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https://www.arca.fiocruz.br/handle/icict/49956 |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Elsevier. International Society for the Study of Xenobiotics |
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Elsevier. International Society for the Study of Xenobiotics |
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