Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2005 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/657 |
Resumo: | Financial support: Faperj E-26/170.409/99, CNPq 33530/2000-0 begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting, WHO, Brazilian Ministry of Health |
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Bongertz, VeraTeixeira, Sylvia Lopes MaiaGrinsztejn, BeatrizPilotto, Jose Henrique da SilvaSantos, Valdiléa Gonçalves Veloso dosMorgado, Mariza GonçalvesBastos, Francisco Inácio Pinkusfeld MonteiroReis, Elaine Priscilla Ouverney2010-08-23T16:58:36Z2010-11-04T14:20:06Z2010-11-04T14:20:06Z2010-08-23T16:58:36Z2005BONGERTZ, Vera et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005.0074-0276https://www.arca.fiocruz.br/handle/icict/657Financial support: Faperj E-26/170.409/99, CNPq 33530/2000-0 begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting, WHO, Brazilian Ministry of HealthFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisa Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Centro de Informações Científicas e Tecnológicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids e Imunologia Molecular, Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.Anti-human immunodeficiency virus type 1 (HIV-1) “binding antibodies” (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1.engFundação Oswaldo CruzHuman immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individualsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHuman Immunodeficiency Virus type 1NeutralizationGenotypeBrazilinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTBastos_HIV_ type 1 neutralization by plasma_2005.pdf.txtBastos_HIV_ type 1 neutralization by plasma_2005.pdf.txtExtracted texttext/plain25945https://www.arca.fiocruz.br/bitstream/icict/657/6/Bastos_HIV_%20type%201%20neutralization%20by%20plasma_2005.pdf.txt0432126966b0a8c4aec6d2f2b9b01f4dMD56LICENSElicense.txttext/plain1841https://www.arca.fiocruz.br/bitstream/icict/657/2/license.txtfb4265d9de23d317f8a32e7dda047458MD52ORIGINALBastos_HIV_ type 1 neutralization by plasma_2005.pdfapplication/pdf49675https://www.arca.fiocruz.br/bitstream/icict/657/3/Bastos_HIV_%20type%201%20neutralization%20by%20plasma_2005.pdfe690b50447282eeb3ee71e9a1d3067efMD53THUMBNAILBastos_HIV_ type 1 neutralization by plasma_2005.pdf.jpgBastos_HIV_ type 1 neutralization by plasma_2005.pdf.jpgGenerated Thumbnailimage/jpeg2504https://www.arca.fiocruz.br/bitstream/icict/657/5/Bastos_HIV_%20type%201%20neutralization%20by%20plasma_2005.pdf.jpg351a9c9ee6885d3ead264addf75ff5cfMD55icict/6572023-09-04 11:17:46.644oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T14:17:46Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| title |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| spellingShingle |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals Bongertz, Vera Human Immunodeficiency Virus type 1 Neutralization Genotype Brazil |
| title_short |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| title_full |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| title_fullStr |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| title_full_unstemmed |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| title_sort |
Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals |
| author |
Bongertz, Vera |
| author_facet |
Bongertz, Vera Teixeira, Sylvia Lopes Maia Grinsztejn, Beatriz Pilotto, Jose Henrique da Silva Santos, Valdiléa Gonçalves Veloso dos Morgado, Mariza Gonçalves Bastos, Francisco Inácio Pinkusfeld Monteiro Reis, Elaine Priscilla Ouverney |
| author_role |
author |
| author2 |
Teixeira, Sylvia Lopes Maia Grinsztejn, Beatriz Pilotto, Jose Henrique da Silva Santos, Valdiléa Gonçalves Veloso dos Morgado, Mariza Gonçalves Bastos, Francisco Inácio Pinkusfeld Monteiro Reis, Elaine Priscilla Ouverney |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Bongertz, Vera Teixeira, Sylvia Lopes Maia Grinsztejn, Beatriz Pilotto, Jose Henrique da Silva Santos, Valdiléa Gonçalves Veloso dos Morgado, Mariza Gonçalves Bastos, Francisco Inácio Pinkusfeld Monteiro Reis, Elaine Priscilla Ouverney |
| dc.subject.en.pt_BR.fl_str_mv |
Human Immunodeficiency Virus type 1 Neutralization Genotype Brazil |
| topic |
Human Immunodeficiency Virus type 1 Neutralization Genotype Brazil |
| description |
Financial support: Faperj E-26/170.409/99, CNPq 33530/2000-0 begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting begin_of_the_skype_highlighting 33530/2000-0 end_of_the_skype_highlighting, WHO, Brazilian Ministry of Health |
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2005 |
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2005 |
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2010-08-23T16:58:36Z 2010-11-04T14:20:06Z |
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2010-11-04T14:20:06Z 2010-08-23T16:58:36Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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BONGERTZ, Vera et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005. |
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https://www.arca.fiocruz.br/handle/icict/657 |
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0074-0276 |
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BONGERTZ, Vera et al. Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 100, n. 1, p. 85-89, Feb. 2005. 0074-0276 |
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