Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals
Main Author: | |
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Publication Date: | 2003 |
Other Authors: | , , , , , |
Format: | Article |
Language: | eng |
Source: | Memórias do Instituto Oswaldo Cruz |
Download full: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200007 |
Summary: | Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU. |
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Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individualshuman immunodeficiency virus-1antibodiesinjection drug usersSera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU.Instituto Oswaldo Cruz, Ministério da Saúde2003-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200007Memórias do Instituto Oswaldo Cruz v.98 n.2 2003reponame:Memórias do Instituto Oswaldo Cruzinstname:Fundação Oswaldo Cruzinstacron:FIOCRUZ10.1590/S0074-02762003000200007info:eu-repo/semantics/openAccessBongertz,VeraOuverney,Elaine PriscillaTeixeira,Sylvia LMSilva-de-Jesus,CarlosHacker,Mariana AMorgado,Mariza GBastos,Francisco Ieng2020-04-25T17:49:01Zhttp://www.scielo.br/oai/scielo-oai.php0074-02761678-8060opendoar:null2020-04-26 02:11:44.671Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruztrue |
dc.title.none.fl_str_mv |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
title |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
spellingShingle |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals Bongertz,Vera human immunodeficiency virus-1 antibodies injection drug users |
title_short |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
title_full |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
title_fullStr |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
title_full_unstemmed |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
title_sort |
Anti-human immunodeficiency virus-1 antibody titers in injection drug users compared to sexually infected individuals |
author |
Bongertz,Vera |
author_facet |
Bongertz,Vera Ouverney,Elaine Priscilla Teixeira,Sylvia LM Silva-de-Jesus,Carlos Hacker,Mariana A Morgado,Mariza G Bastos,Francisco I |
author_role |
author |
author2 |
Ouverney,Elaine Priscilla Teixeira,Sylvia LM Silva-de-Jesus,Carlos Hacker,Mariana A Morgado,Mariza G Bastos,Francisco I |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Bongertz,Vera Ouverney,Elaine Priscilla Teixeira,Sylvia LM Silva-de-Jesus,Carlos Hacker,Mariana A Morgado,Mariza G Bastos,Francisco I |
dc.subject.por.fl_str_mv |
human immunodeficiency virus-1 antibodies injection drug users |
topic |
human immunodeficiency virus-1 antibodies injection drug users |
dc.description.none.fl_txt_mv |
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU. |
description |
Sera from infected injection drug users (IDU) have shown to have antibodies against synthetic human immunodeficiency virus-1 (HIV-1) envelope peptides more frequently. In this study, reactivity of 48 IDU plasma were compared to 60 plasmas obtained from sexually infected individuals (S). The overall reactivity of plasma from IDU compared to S was higher, and the reactivity titers were much higher for IDU plasma than S. IDU plasma also showed a broader antibody response. The higher reactivity titers were observed mainly for the gp41 immunodominant epitope and V3 peptides corresponding to the consensus sequences of HIV-1 subtypes/variants prevalent in Brazil (B, F, C) indicating the specificity in the higher immune response of IDU. |
publishDate |
2003 |
dc.date.none.fl_str_mv |
2003-03-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200007 |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000200007 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0074-02762003000200007 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
dc.source.none.fl_str_mv |
Memórias do Instituto Oswaldo Cruz v.98 n.2 2003 reponame:Memórias do Instituto Oswaldo Cruz instname:Fundação Oswaldo Cruz instacron:FIOCRUZ |
reponame_str |
Memórias do Instituto Oswaldo Cruz |
collection |
Memórias do Instituto Oswaldo Cruz |
instname_str |
Fundação Oswaldo Cruz |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
repository.name.fl_str_mv |
Memórias do Instituto Oswaldo Cruz - Fundação Oswaldo Cruz |
repository.mail.fl_str_mv |
|
_version_ |
1669937688147394560 |