Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection

Detalhes bibliográficos
Autor(a) principal: Lima Junior, Josué da Costa
Data de Publicação: 2016
Outros Autores: Riccio, Lilian Rose Pratt
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/16541
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.
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spelling Lima Junior, Josué da CostaRiccio, Lilian Rose Pratt2016-12-15T12:49:34Z2016-12-15T12:49:34Z2016LIMA JUNIOR, Josué da Costa; RICCIO, Lilan Rose Pratt. Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax infection. Frontiers in Immunology, v.7, Article 13, 13p, Jan. 2016.1664-3224https://www.arca.fiocruz.br/handle/icict/1654110.3389/fimmu.2016.00013engFrontiers MediaMaláriaPlasmodium vivaxVacinaComplexo de HistocompatibilidademalariaP.vivaxMHCHLAvaccineMajor Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz, Instituto Oswaldo Cruz. Laboratório de Pesquisa em Malária. Rio de Janeiro, RJ, Brasil.The importance of host and parasite genetic factors in malaria resistance or susceptibility has been investigated since the middle of the last century. Nowadays, of all diseases that affect man, malaria still plays one of the highest levels of selective pressure on human genome. Susceptibility to malaria depends on exposure profile, epidemiological characteristics, and several components of the innate and adaptive immune system that influences the quality of the immune response generated during the Plasmodium lifecycle in the vertebrate host. But it is well known that the parasite's enormous capacity of genetic variation in conjunction with the host genetics polymorphism is also associated with a wide spectrum of susceptibility degrees to complicated or severe forms of the disease. In this scenario, variations in genes of the major histocompatibility complex (MHC) associated with host resistance or susceptibility to malaria have been identified and used as markers in host-pathogen interaction studies, mainly those evaluating the impact on the immune response, acquisition of resistance, or increased susceptibility to infection or vulnerability to disease. However, due to the intense selective pressure, number of cases, and mortality rates, the majority of the reported associations reported concerned Plasmodium falciparum malaria. Studies on the MHC polymorphism and its association with Plasmodium vivax, which is the most widespread Plasmodium and the most prevalent species outside the African continent, are less frequent but equally important. Despite punctual contributions, there are accumulated evidences of human genetic control in P. vivax infection and disease. Herein, we review the current knowledge in the field of MHC and derived molecules (HLA Class I, Class II, TNF-α, LTA, BAT1, and CTL4) regarding P. vivax malaria. We discuss particularly the results of P. vivax studies on HLA class I and II polymorphisms in relation to host susceptibility, naturally acquired immune response against specific antigens and the implication of this knowledge to overcome the parasite immune evasion. 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dc.title.pt_BR.fl_str_mv Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
title Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
spellingShingle Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
Lima Junior, Josué da Costa
Malária
Plasmodium vivax
Vacina
Complexo de Histocompatibilidade
malaria
P.vivax
MHC
HLA
vaccine
title_short Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
title_full Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
title_fullStr Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
title_full_unstemmed Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
title_sort Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax Infection
author Lima Junior, Josué da Costa
author_facet Lima Junior, Josué da Costa
Riccio, Lilian Rose Pratt
author_role author
author2 Riccio, Lilian Rose Pratt
author2_role author
dc.contributor.author.fl_str_mv Lima Junior, Josué da Costa
Riccio, Lilian Rose Pratt
dc.subject.other.pt_BR.fl_str_mv Malária
Plasmodium vivax
Vacina
Complexo de Histocompatibilidade
topic Malária
Plasmodium vivax
Vacina
Complexo de Histocompatibilidade
malaria
P.vivax
MHC
HLA
vaccine
dc.subject.en.pt_BR.fl_str_mv malaria
P.vivax
MHC
HLA
vaccine
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ. Brasil.
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-12-15T12:49:34Z
dc.date.available.fl_str_mv 2016-12-15T12:49:34Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv LIMA JUNIOR, Josué da Costa; RICCIO, Lilan Rose Pratt. Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax infection. Frontiers in Immunology, v.7, Article 13, 13p, Jan. 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/16541
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2016.00013
identifier_str_mv LIMA JUNIOR, Josué da Costa; RICCIO, Lilan Rose Pratt. Major Histocompatibility Complex and Malaria: Focus on Plasmodium vivax infection. Frontiers in Immunology, v.7, Article 13, 13p, Jan. 2016.
1664-3224
10.3389/fimmu.2016.00013
url https://www.arca.fiocruz.br/handle/icict/16541
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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