Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence

Detalhes bibliográficos
Autor(a) principal: Castro, Taciana Padilha de
Data de Publicação: 2019
Outros Autores: Penha, Ricardo Cortez Cardoso, Buexm, Luisa Aguirre, Carvalho, Flávia Nascimento de, Oliveira, Raquel de Vasconcellos Carvalhaes, Vaz Agarez, Fernando, Pinto, Luciana Wernersbach, Carvalho, Denise P.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/57023
Resumo: This work was supported by Netcon (Consulting and engineering company), Pro Onco Vivi Nabuco-Fundação do Câncer, Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq no. 404150/2016-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
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spelling Castro, Taciana Padilha dePenha, Ricardo Cortez CardosoBuexm, Luisa AguirreCarvalho, Flávia Nascimento deOliveira, Raquel de Vasconcellos CarvalhaesVaz Agarez, FernandoPinto, Luciana WernersbachCarvalho, Denise P.2023-02-11T16:10:13Z2023-02-11T16:10:13Z2019CASTRO, Taciana Padilha de et al. Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence. Frontiers in Endocrinology, v. 10, Article 839, p. 1-9, Dec. 2019.1664-2392https://www.arca.fiocruz.br/handle/icict/5702310.3389/fendo.2019.008391664-2392This work was supported by Netcon (Consulting and engineering company), Pro Onco Vivi Nabuco-Fundação do Câncer, Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq no. 404150/2016-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Oswaldo Cruz Foundation. National School of Public Health Sergio Arouca. Center for Health Work and Human Ecology. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Molecular Carcinogenesis Program. Research Center. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Molecular Carcinogenesis Program. Research Center. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Molecular Carcinogenesis Program. Research Center. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Helmintos Parasitos de Vertebrados. Rio de Janeiro, RJ, Brasil.Oswaldo Cruz Foundation. Evandro Chagas National Institute of Infectious Diseases. Clinical Epidemiology Laboratory. Rio de Janeiro, RJ, Brazil.National Cancer Institute. Pathology Division. Rio de Janeiro, RJ, Brazil.National Cancer Institute. Pathology Division. Rio de Janeiro, RJ, Brazil.Federal University of Rio de Janeiro. Institute of Biophysics Carlos Chagas Filho. Endocrine Physiology Laboratory Doris Rosenthal. Rio de Janeiro, RJ, Brazil.Despite its indolent course, one-third of the papillary thyroid carcinoma (PTC) cases relapses, which directly impact on the quality of patients' lives. The molecular predictors of recurrence of PTC are poorly defined. We aimed at evaluating the long-term (10-20 years) prognostic value of aggressiveness markers in advanced PTC. To this end, immunohistochemistry for BRAFV600E, Estrogen receptor α, Progesterone receptor, Ki-67, and E-cadherin were performed in 53 primary advanced PTC from an up to 20 years follow-up patients from a well-characterized Brazilian cohort. Categorical data were summarized using frequencies and groups were compared using Chi-squared and Fisher's exact tests. The expressions of the aggressiveness markers were associated with clinical-pathological data using the single-covariate logistic regression analysis. The Kaplan-Meier method with the Log-rank and Peto tests was used to estimate the probability of PTC-free survival. Persistence and recurrence (active disease) were associated with age (≥55 years), tumor size (>2 cm), extrathyroidal extension, local aggressiveness, macroscopic lymph node metastasis, and TNM stage at initial treatment. The BRAFV600E mutation status was associated with extrathyroidal extension, local aggressiveness, and inversely associated with distant metastasis at initial treatment. All progesterone receptor-positive patients had active disease and displayed a shorter time of PTC-free survival than the negative ones using the Kaplan-Meir analysis (p = 0.001, Log Rank; p = 0.005, Peto). Loss of E-cadherin expression was associated with an increase in the probability of active disease (OR = 3.75). BRAFV600E could be useful as a biomarker of local aggressiveness, while PR positive and E-cadherin loss of expression could predict the recurrence of advanced PTC.engFrontiers Research FoundationMolecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrenceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBRAFV600EE-cadherinPapillary thyroid carcinomaProgesterone receptorRecurrenceinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALve_Taciana_Castro_etal_INI_ENSP_2019.pdfve_Taciana_Castro_etal_INI_ENSP_2019.pdfapplication/pdf2746838https://www.arca.fiocruz.br/bitstream/icict/57023/2/ve_Taciana_Castro_etal_INI_ENSP_2019.pdf1ac446ac53ce6c9adb74f19b2198fc55MD52LICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/57023/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51icict/570232023-07-10 20:33:06.608oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-07-10T23:33:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
title Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
spellingShingle Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
Castro, Taciana Padilha de
BRAFV600E
E-cadherin
Papillary thyroid carcinoma
Progesterone receptor
Recurrence
title_short Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
title_full Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
title_fullStr Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
title_full_unstemmed Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
title_sort Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence
author Castro, Taciana Padilha de
author_facet Castro, Taciana Padilha de
Penha, Ricardo Cortez Cardoso
Buexm, Luisa Aguirre
Carvalho, Flávia Nascimento de
Oliveira, Raquel de Vasconcellos Carvalhaes
Vaz Agarez, Fernando
Pinto, Luciana Wernersbach
Carvalho, Denise P.
author_role author
author2 Penha, Ricardo Cortez Cardoso
Buexm, Luisa Aguirre
Carvalho, Flávia Nascimento de
Oliveira, Raquel de Vasconcellos Carvalhaes
Vaz Agarez, Fernando
Pinto, Luciana Wernersbach
Carvalho, Denise P.
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Castro, Taciana Padilha de
Penha, Ricardo Cortez Cardoso
Buexm, Luisa Aguirre
Carvalho, Flávia Nascimento de
Oliveira, Raquel de Vasconcellos Carvalhaes
Vaz Agarez, Fernando
Pinto, Luciana Wernersbach
Carvalho, Denise P.
dc.subject.en.en_US.fl_str_mv BRAFV600E
E-cadherin
Papillary thyroid carcinoma
Progesterone receptor
Recurrence
topic BRAFV600E
E-cadherin
Papillary thyroid carcinoma
Progesterone receptor
Recurrence
description This work was supported by Netcon (Consulting and engineering company), Pro Onco Vivi Nabuco-Fundação do Câncer, Fundação de Amparo à Pesquisa do Rio de Janeiro (FAPERJ), and Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq no. 404150/2016-0). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2023-02-11T16:10:13Z
dc.date.available.fl_str_mv 2023-02-11T16:10:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Taciana Padilha de et al. Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence. Frontiers in Endocrinology, v. 10, Article 839, p. 1-9, Dec. 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/57023
dc.identifier.issn.en_US.fl_str_mv 1664-2392
dc.identifier.doi.none.fl_str_mv 10.3389/fendo.2019.00839
dc.identifier.eissn.none.fl_str_mv 1664-2392
identifier_str_mv CASTRO, Taciana Padilha de et al. Molecular Predictors for Advanced Papillary Thyroid Carcinoma Recurrence. Frontiers in Endocrinology, v. 10, Article 839, p. 1-9, Dec. 2019.
1664-2392
10.3389/fendo.2019.00839
url https://www.arca.fiocruz.br/handle/icict/57023
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/57023/2/ve_Taciana_Castro_etal_INI_ENSP_2019.pdf
https://www.arca.fiocruz.br/bitstream/icict/57023/1/license.txt
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repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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