Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/42318 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES—Finance Code 001), CNPq, FACEPE, FINEP and FUNCAP. |
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Martins, Anita Oliveira Brito Pereira BezerraWanderley, Almir GonçalvesAlcântara, Isabel SousaRodrigues, Lindaiane BezerraCesário, Francisco Rafael Alves SantanaOliveira, Maria Rayane Correia deCastro, Fyama Ferreira EAlbuquerque, Thaís Rodrigues deSilva, Maria Sanadia Alexandre daRibeiro Filho, JaimeCoutinho, Henrique Douglas MeloMenezes, Paula PassosQuintans Júnior, Lucindo JoséAraújo, Adriano Antunes de SouzaIriti, MarcelloAlmeida, Jackson Roberto Guedes da SilvaMenezes, Irwin Rose Alencar de2020-07-21T12:19:52Z2020-07-21T12:19:52Z2020MARTINS, Anita Oliveira Brito Pereira Bezerra et al. Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin. Biology, v. 9, 2020.s/idhttps://www.arca.fiocruz.br/handle/icict/4231810.3390/biology9060114Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES—Finance Code 001), CNPq, FACEPE, FINEP and FUNCAP.Federal University of Pernambuco. Laboratory of Pharmacology and Preclinical Bioactive Product Toxicology. Recife, PE, Brazil.Federal University of Pernambuco. Laboratory of Pharmacology and Preclinical Bioactive Product Toxicology. Recife, PE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Federal University of Ceara. Laboratory of Pharmacology and Molecular Chemistry. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.University of Cariri. Laboratory of Microbiology and Molecular Biology. Department of Biological Chemistry. Crato, CE, Brazil.Federal University of Sergipe. Laboratory of Pharmaceutical Testing and Toxicity. Department of Pharmacy. São Cristóvão, SE, Brazil.Federal University of Sergipe. Laboratory of Neuroscience and Pharmacological Assays. Department of Physiology. São Cristóvão, SE, Brazil.Federal University of Sergipe. Laboratory of Neuroscience and Pharmacological Assays. Department of Physiology. São Cristóvão, SE, Brazil.Milan State University. Department of Agricultural and Environmental Sciences. Milan, Italy.Federal University of Vale Sao Francisco. Laboratory of Pharmacology. Department of Pharmacy. Petrolina, PE, Brazil.Regional University of Cariri. Laboratory of Pharmacology and Molecular Chemistry. Department of Biological Chemistry, Pimenta, Crato, CE, Brazil.Croton rhamnifolioides is used in popular medicine for the treatment of inflammatory diseases. The objective of this study was to characterize and evaluate the anti-inflammatory effect of C. rhamnifolioides essential oil complexed in β-cyclodextrin (COEFC). The physicochemical characterization of the complexes was performed using different physical methods. The anti-inflammatory activity was evaluated in vivo by ear edema, paw edema, cotton pellet-induced granuloma, and vascular permeability by Evans blue extravasation. The mechanism of action was validated by molecular docking of the major constituent into the cyclooxygenase-2 (COX-2 enzyme). All doses of the COEFC reduced acute paw edema induced by carrageenan and dextran, as well as vascular permeability. Our results suggest the lowest effective dose of all samples inhibited the response induced by histamine or arachidonic acid as well as the granuloma formation. The complexation process showed that the pharmacological effects were maintained, however, showing similar results using much lower doses. The results demonstrated an involvement of the inhibition of pathways dependent on eicosanoids and histamine. Complexation of β-cyclodextrin/Essential oil (β-CD/EO) may present an important tool in the study of new compounds for the development of anti-inflammatory drugs.engMDPICroton rhamnifolioidesCiclodextrinaInflamaçãoCroton rhamnifolioidesCyclodextrinInflammationAnti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42318/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMartins, Anita Oliveira Brito Pereira Anti-inflamatory....pdfMartins, Anita Oliveira Brito Pereira Anti-inflamatory....pdfapplication/pdf2579794https://www.arca.fiocruz.br/bitstream/icict/42318/2/Martins%2c%20Anita%20Oliveira%20Brito%20Pereira%20Anti-inflamatory....pdf7ae894996c4d9bb213354d76465060b1MD52TEXTMartins, Anita Oliveira Brito Pereira Anti-inflamatory....pdf.txtMartins, Anita Oliveira Brito Pereira Anti-inflamatory....pdf.txtExtracted texttext/plain115090https://www.arca.fiocruz.br/bitstream/icict/42318/3/Martins%2c%20Anita%20Oliveira%20Brito%20Pereira%20Anti-inflamatory....pdf.txtd6ceb4d6f83bf401dfc0b1e76047f778MD53icict/423182023-03-15 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| dc.title.pt_BR.fl_str_mv |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| title |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| spellingShingle |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin Martins, Anita Oliveira Brito Pereira Bezerra Croton rhamnifolioides Ciclodextrina Inflamação Croton rhamnifolioides Cyclodextrin Inflammation |
| title_short |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| title_full |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| title_fullStr |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| title_full_unstemmed |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| title_sort |
Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin |
| author |
Martins, Anita Oliveira Brito Pereira Bezerra |
| author_facet |
Martins, Anita Oliveira Brito Pereira Bezerra Wanderley, Almir Gonçalves Alcântara, Isabel Sousa Rodrigues, Lindaiane Bezerra Cesário, Francisco Rafael Alves Santana Oliveira, Maria Rayane Correia de Castro, Fyama Ferreira E Albuquerque, Thaís Rodrigues de Silva, Maria Sanadia Alexandre da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Menezes, Paula Passos Quintans Júnior, Lucindo José Araújo, Adriano Antunes de Souza Iriti, Marcello Almeida, Jackson Roberto Guedes da Silva Menezes, Irwin Rose Alencar de |
| author_role |
author |
| author2 |
Wanderley, Almir Gonçalves Alcântara, Isabel Sousa Rodrigues, Lindaiane Bezerra Cesário, Francisco Rafael Alves Santana Oliveira, Maria Rayane Correia de Castro, Fyama Ferreira E Albuquerque, Thaís Rodrigues de Silva, Maria Sanadia Alexandre da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Menezes, Paula Passos Quintans Júnior, Lucindo José Araújo, Adriano Antunes de Souza Iriti, Marcello Almeida, Jackson Roberto Guedes da Silva Menezes, Irwin Rose Alencar de |
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author author author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Martins, Anita Oliveira Brito Pereira Bezerra Wanderley, Almir Gonçalves Alcântara, Isabel Sousa Rodrigues, Lindaiane Bezerra Cesário, Francisco Rafael Alves Santana Oliveira, Maria Rayane Correia de Castro, Fyama Ferreira E Albuquerque, Thaís Rodrigues de Silva, Maria Sanadia Alexandre da Ribeiro Filho, Jaime Coutinho, Henrique Douglas Melo Menezes, Paula Passos Quintans Júnior, Lucindo José Araújo, Adriano Antunes de Souza Iriti, Marcello Almeida, Jackson Roberto Guedes da Silva Menezes, Irwin Rose Alencar de |
| dc.subject.other.pt_BR.fl_str_mv |
Croton rhamnifolioides Ciclodextrina Inflamação |
| topic |
Croton rhamnifolioides Ciclodextrina Inflamação Croton rhamnifolioides Cyclodextrin Inflammation |
| dc.subject.en.pt_BR.fl_str_mv |
Croton rhamnifolioides Cyclodextrin Inflammation |
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES—Finance Code 001), CNPq, FACEPE, FINEP and FUNCAP. |
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2020 |
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2020-07-21T12:19:52Z |
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2020-07-21T12:19:52Z |
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2020 |
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MARTINS, Anita Oliveira Brito Pereira Bezerra et al. Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin. Biology, v. 9, 2020. |
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https://www.arca.fiocruz.br/handle/icict/42318 |
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s/id |
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10.3390/biology9060114 |
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MARTINS, Anita Oliveira Brito Pereira Bezerra et al. Anti-Inflammatory and Physicochemical Characterization of the Croton Rhamnifolioides Essential Oil Inclusion Complex in β-Cyclodextrin. Biology, v. 9, 2020. s/id 10.3390/biology9060114 |
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