Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis

Detalhes bibliográficos
Autor(a) principal: Johann, Susana
Data de Publicação: 2012
Outros Autores: Rosa, Luiz Henrique, Rosa, Carlos Augusto, Perez, Pilar, Cisalpino, Patrícia Silva, Zani, Carlos Leomar, Cota, Betania Barros
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7625
Resumo: Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil
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spelling Johann, SusanaRosa, Luiz HenriqueRosa, Carlos AugustoPerez, PilarCisalpino, Patrícia SilvaZani, Carlos LeomarCota, Betania Barros2014-05-14T14:29:47Z2014-05-14T14:29:47Z2012JOHANN, Susana et al. Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis. Revista Iberoamericana Micología, vol. 29, n.4, pp. 205-209, 20121130-1406https://www.arca.fiocruz.br/handle/icict/762510.1016/j.riam.2012.02.002engElsevier EspanaAntifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilUniversidad de Salamanca. Instituto de Microbiología Bioquímica CSIC. Salamanca, SpainUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, BrazilBACKGROUND: Altenusin is a biphenyl derivative isolated from different species of fungi, which presents several biological activities. AIMS: We report the antifungal activity of the altenusin isolated from the endophytic fungus Alternaria sp., against clinical isolates of Paracoccidioides brasiliensis, and its action on cell walls of P. brasiliensis and the nonpathogenic yeast Schizosaccharomyces pombe. METHODS: In vitro antifungal activity of altenusin was evaluated using the broth microdilution method against 11 strains of P. brasiliensis and one strain of S. pombe. The effects of the altenusin on the cell wall were estimated using the sorbitol protection assay. RESULTS: The altenusin presented strong activity against P. brasiliensis with MIC values ranging between 1.9 and 31.2 μg/ml, and 62.5 μg/ml for S. pombe. Our results demonstrated that the MIC values for altenusin were increased for P. brasiliensis Pb18 and for S. pombe when the medium was supplemented with sorbitol. Additionally, S. pombe cells treated with altenusin were more rounded in shape than untreated cells. CONCLUSIONS: Altenusin showed activity against clinical strains of P. brasiliensis at the concentration tested, and this compound probably affects fungal cell walls. These findings suggest that altenusin could act through the inhibition of cell wall synthesis or assembly in P. brasiliensis and S. pombe, and could be considered as a lead compound for the design of new antifungals.Paracoccidioides brasiliensisAntifungal activityGC-MStraditional medicinal plantsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAntifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioi.pdfAntifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioi.pdfapplication/pdf1006513https://www.arca.fiocruz.br/bitstream/icict/7625/1/Antifungal%20activity%20of%20altenusin%20isolated%20from%20the%20endophytic%20fungus%20Alternaria%20sp.%20against%20the%20pathogenic%20fungus%20Paracoccidioi.pdf1a2639c71c9509c25480c729404e1e02MD51LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
title Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
spellingShingle Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
Johann, Susana
Paracoccidioides brasiliensis
Antifungal activity
GC-MS
traditional medicinal plants
title_short Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
title_full Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
title_fullStr Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
title_full_unstemmed Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
title_sort Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis
author Johann, Susana
author_facet Johann, Susana
Rosa, Luiz Henrique
Rosa, Carlos Augusto
Perez, Pilar
Cisalpino, Patrícia Silva
Zani, Carlos Leomar
Cota, Betania Barros
author_role author
author2 Rosa, Luiz Henrique
Rosa, Carlos Augusto
Perez, Pilar
Cisalpino, Patrícia Silva
Zani, Carlos Leomar
Cota, Betania Barros
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Johann, Susana
Rosa, Luiz Henrique
Rosa, Carlos Augusto
Perez, Pilar
Cisalpino, Patrícia Silva
Zani, Carlos Leomar
Cota, Betania Barros
dc.subject.en.pt_BR.fl_str_mv Paracoccidioides brasiliensis
Antifungal activity
GC-MS
traditional medicinal plants
topic Paracoccidioides brasiliensis
Antifungal activity
GC-MS
traditional medicinal plants
description Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Química de Produtos Naturais. Belo Horizonte, MG, Brazil
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2014-05-14T14:29:47Z
dc.date.available.fl_str_mv 2014-05-14T14:29:47Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv JOHANN, Susana et al. Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis. Revista Iberoamericana Micología, vol. 29, n.4, pp. 205-209, 2012
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7625
dc.identifier.issn.none.fl_str_mv 1130-1406
dc.identifier.doi.none.fl_str_mv 10.1016/j.riam.2012.02.002
identifier_str_mv JOHANN, Susana et al. Antifungal activity of altenusin isolated from the endophytic fungus Alternaria sp. against the pathogenic fungus Paracoccidioides brasiliensis. Revista Iberoamericana Micología, vol. 29, n.4, pp. 205-209, 2012
1130-1406
10.1016/j.riam.2012.02.002
url https://www.arca.fiocruz.br/handle/icict/7625
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier Espana
publisher.none.fl_str_mv Elsevier Espana
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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