Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/47060 |
Resumo: | Fundação Centro de Controle de Oncologia do Estado do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brasil. / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. |
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Santana, Monique FreirePinto, Rebecca Augusta de AraújoMarcon, Bruna HilzendegerMedeiros, Lia Carolina SoaresMorais, Thiago Barros do Nascimento deDias, Lucas CastanholaSouza, Lorenna Pereira deMelo, Gisely Cardoso deMonteiro, Wuelton MarceloLacerda, Marcus Vinicius GuimarãesVal, Fernando AlmeidaLalwani, Pritesh JaychandFerreira, Luiz Carlos de Lima2021-05-05T17:57:48Z2021-05-05T17:57:48Z2021SANTANA, Monique Freire et al. Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy. Revista da Sociedade Brasileira de Medicina Tropical, v.54, p. 1–7, 2021.1678-9849https://www.arca.fiocruz.br/handle/icict/4706010.1590/0037-8682-0850-2020porSociedade Brasileira de Medicina TropicalCOVID-19Doença PulmonarCoronavirus InfectionsSevere Acute Respiratory SyndromeLung DiseasesElectron MicroscopyAlveolar Epithelial CellsPostmortem evidenceInfecciones por CoronavirusSíndrome Respiratorio Agudo GraveEnfermedades PulmonaresMicroscopía ElectrónicaCélulas Epiteliales AlveolaresInfections à coronavirusSyndrome respiratoire aigu sévèreMaladies pulmonairesMicroscopie électroniquePneumocytesExamen postmortemInfecções por CoronavirusSíndrome Respiratória Aguda GravePneumopatiasMicroscopia EletrônicaCélulas Epiteliais AlveolaresNecrópsiaPathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Centro de Controle de Oncologia do Estado do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brasil. / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Hospital Universitário Getúlio Vargas. Programa de Residência Médica em Patologia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brasil.Instituto Nacional de Pesquisas da Amazônia. Laboratório Temático de Microscopia e Nanotecnologia. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil. / Universidade Federal do Amazonas. Programa de Pós-Graduação em Ciências da Saúde. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto de Pesquisas Leônidas & Maria Deane. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. / Hospital Universitário Getúlio Vargas. Programa de Residência Médica em Patologia. Manaus, AM, Brasil. / Universidade Federal do Amazonas. Programa de Pós-Graduação em Ciências da Saúde. Manaus, AM, Brasil.Electron microscopy (EM) is a rapid and effective tool that can be used to create images of a whole spectrum of virus-host interactions and, as such, has long been used in the discovery and description of viral mechanisms. Methods: Electron microscopy was used to evaluate the pulmonary pathologies of postmortem lung sections from three patients who died from infection with SARS-associated coronavirus 2 (SARS-CoV-2), a new member of the Coronaviridae family. Results: Diffuse alveolar damage (DAD) was predominant in all three patients. The early exudative stage was characterized principally by edema and extravasation of red blood cells into the alveolar space with injury to the alveolar epithelial cells; this was followed by detachment, apoptosis, and necrosis of type I and II pneumocytes. The capillaries exhibited congestion, exposure of the basement membrane from denuded endothelial cells, platelet adhesion, fibrin thrombi, and rupture of the capillary walls. The proliferative stage was characterized by pronounced proliferation of type II alveolar pneumocytes and multinucleated giant cells. The cytopathic effect of SARS-CoV-2 was observed both in degenerated type II pneumocytes and freely circulating in the alveoli, with components from virions, macrophages, lymphocytes, and cellular debris. Conclusions: Viral particles consistent with the characteristics of SARS-CoV-2 were observed mainly in degenerated pneumocytes, in the endothelium, or freely circulating in the alveoli. In the final stage of illness, the alveolar spaces were replaced by fibrosis.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/47060/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINAL1678-9849-rsbmt-54-e0850OK.pdf1678-9849-rsbmt-54-e0850OK.pdfapplication/pdf3480853https://www.arca.fiocruz.br/bitstream/icict/47060/2/1678-9849-rsbmt-54-e0850OK.pdf030a085ec7a9edd3cd342cab944ba8adMD52TEXT1678-9849-rsbmt-54-e0850OK.pdf.txt1678-9849-rsbmt-54-e0850OK.pdf.txtExtracted texttext/plain30744https://www.arca.fiocruz.br/bitstream/icict/47060/3/1678-9849-rsbmt-54-e0850OK.pdf.txt64b19663d736dd0a55cc7cfe28628d9eMD53icict/470602022-03-24 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| dc.title.pt_BR.fl_str_mv |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| title |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| spellingShingle |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy Santana, Monique Freire COVID-19 Doença Pulmonar Coronavirus Infections Severe Acute Respiratory Syndrome Lung Diseases Electron Microscopy Alveolar Epithelial Cells Postmortem evidence Infecciones por Coronavirus Síndrome Respiratorio Agudo Grave Enfermedades Pulmonares Microscopía Electrónica Células Epiteliales Alveolares Infections à coronavirus Syndrome respiratoire aigu sévère Maladies pulmonaires Microscopie électronique Pneumocytes Examen postmortem Infecções por Coronavirus Síndrome Respiratória Aguda Grave Pneumopatias Microscopia Eletrônica Células Epiteliais Alveolares Necrópsia |
| title_short |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| title_full |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| title_fullStr |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| title_full_unstemmed |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| title_sort |
Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy |
| author |
Santana, Monique Freire |
| author_facet |
Santana, Monique Freire Pinto, Rebecca Augusta de Araújo Marcon, Bruna Hilzendeger Medeiros, Lia Carolina Soares Morais, Thiago Barros do Nascimento de Dias, Lucas Castanhola Souza, Lorenna Pereira de Melo, Gisely Cardoso de Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães Val, Fernando Almeida Lalwani, Pritesh Jaychand Ferreira, Luiz Carlos de Lima |
| author_role |
author |
| author2 |
Pinto, Rebecca Augusta de Araújo Marcon, Bruna Hilzendeger Medeiros, Lia Carolina Soares Morais, Thiago Barros do Nascimento de Dias, Lucas Castanhola Souza, Lorenna Pereira de Melo, Gisely Cardoso de Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães Val, Fernando Almeida Lalwani, Pritesh Jaychand Ferreira, Luiz Carlos de Lima |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Santana, Monique Freire Pinto, Rebecca Augusta de Araújo Marcon, Bruna Hilzendeger Medeiros, Lia Carolina Soares Morais, Thiago Barros do Nascimento de Dias, Lucas Castanhola Souza, Lorenna Pereira de Melo, Gisely Cardoso de Monteiro, Wuelton Marcelo Lacerda, Marcus Vinicius Guimarães Val, Fernando Almeida Lalwani, Pritesh Jaychand Ferreira, Luiz Carlos de Lima |
| dc.subject.other.pt_BR.fl_str_mv |
COVID-19 Doença Pulmonar |
| topic |
COVID-19 Doença Pulmonar Coronavirus Infections Severe Acute Respiratory Syndrome Lung Diseases Electron Microscopy Alveolar Epithelial Cells Postmortem evidence Infecciones por Coronavirus Síndrome Respiratorio Agudo Grave Enfermedades Pulmonares Microscopía Electrónica Células Epiteliales Alveolares Infections à coronavirus Syndrome respiratoire aigu sévère Maladies pulmonaires Microscopie électronique Pneumocytes Examen postmortem Infecções por Coronavirus Síndrome Respiratória Aguda Grave Pneumopatias Microscopia Eletrônica Células Epiteliais Alveolares Necrópsia |
| dc.subject.en.pt_BR.fl_str_mv |
Coronavirus Infections Severe Acute Respiratory Syndrome Lung Diseases Electron Microscopy Alveolar Epithelial Cells Postmortem evidence |
| dc.subject.es.pt_BR.fl_str_mv |
Infecciones por Coronavirus Síndrome Respiratorio Agudo Grave Enfermedades Pulmonares Microscopía Electrónica Células Epiteliales Alveolares |
| dc.subject.fr.pt_BR.fl_str_mv |
Infections à coronavirus Syndrome respiratoire aigu sévère Maladies pulmonaires Microscopie électronique Pneumocytes Examen postmortem |
| dc.subject.decs.pt_BR.fl_str_mv |
Infecções por Coronavirus Síndrome Respiratória Aguda Grave Pneumopatias Microscopia Eletrônica Células Epiteliais Alveolares Necrópsia |
| description |
Fundação Centro de Controle de Oncologia do Estado do Amazonas. Departamento de Ensino e Pesquisa. Manaus, AM, Brasil. / Universidade do Estado do Amazonas. Programa de Pós-Graduação em Medicina Tropical. Manaus, AM, Brasil. / Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. Manaus, AM, Brasil. |
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2021 |
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2021-05-05T17:57:48Z |
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2021-05-05T17:57:48Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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SANTANA, Monique Freire et al. Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy. Revista da Sociedade Brasileira de Medicina Tropical, v.54, p. 1–7, 2021. |
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https://www.arca.fiocruz.br/handle/icict/47060 |
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1678-9849 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/0037-8682-0850-2020 |
| identifier_str_mv |
SANTANA, Monique Freire et al. Pathological findings and morphologic correlation of the lungs of autopsied patients with SARS-CoV-2 infection in the Brazilian Amazon using transmission electron microscopy. Revista da Sociedade Brasileira de Medicina Tropical, v.54, p. 1–7, 2021. 1678-9849 10.1590/0037-8682-0850-2020 |
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Sociedade Brasileira de Medicina Tropical |
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