Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score

Detalhes bibliográficos
Autor(a) principal: Palomba, Henrique
Data de Publicação: 2023
Outros Autores: Cubos, Daniel, Bozza, Fernando, Zampieri, Fernando Godinho, Romano, Thiago Gomes
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1186/s12882-023-03095-4
Texto Completo: https://www.arca.fiocruz.br/handle/icict/58976
Resumo: Ethics approval and consent to participate The study was approved by the National Teaching and Ethical Committee (CONEP) in São Paulo / Brazil, number: 29496920.8.0000.5262 and informed consent was waived due to the observational nature of the study. The study was performed in accordance with the Declaration of Helsinki, the International Council for Harmonization and Good Clinical Practice.
id CRUZ_fc24f152252bd14a0180cc881679cbcf
oai_identifier_str oai:www.arca.fiocruz.br:icict/58976
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Palomba, HenriqueCubos, DanielBozza, FernandoZampieri, Fernando GodinhoRomano, Thiago Gomes2023-06-08T00:11:35Z2023-06-08T00:11:35Z2023PALOMBA, Henrique et al. Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score. BMC Nephrology, v. 24, n. 1, p. 1-8, Mar. 2023.1471-2369https://www.arca.fiocruz.br/handle/icict/5897610.1186/s12882-023-03095-41471-2369Ethics approval and consent to participate The study was approved by the National Teaching and Ethical Committee (CONEP) in São Paulo / Brazil, number: 29496920.8.0000.5262 and informed consent was waived due to the observational nature of the study. The study was performed in accordance with the Declaration of Helsinki, the International Council for Harmonization and Good Clinical Practice.Hospital Vila Nova Star - ICU. Critical Care Nephrology Department. São Paulo, SP, Brazil.Hospital Vila Nova Star - ICU. Critical Care Nephrology Department. São Paulo, SP, Brazil / Instituto D'Or de Pesquisa e Ensino. São Paulo, SP, Brazil.Instituto D'Or de Pesquisa e Ensino. São Paulo, SP, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brazil.Hospital Vila Nova Star - ICU. Critical Care Nephrology Department. São Paulo, SP, Brazil.Hospital Vila Nova Star - ICU. Critical Care Nephrology Department. São Paulo, SP, Brazil / Instituto D'Or de Pesquisa e Ensino. São Paulo, SP, Brazil / Hospital São Luiz Itaim. Oncologic Critical Care Department. São Paulo, SP, Brazil / ABC Medical School Nephrology Department Assistant Professor. Santo André, SP, Brazil.Purpose: Acute Kidney Injury (AKI) in COVID-19 patients is associated with increased morbidity and mortality. In the present study, we aimed to develop a prognostic score to predict AKI development in these patients. Materials and methods: This was a retrospective observational study of 2334 COVID 19 patients admitted to 23 different hospitals in Brazil, between January 10th and August 30rd, 2020. The primary outcome of AKI was defined as any increase in serum creatinine (SCr) by 0.3 mg/dL within 48 h or a change in SCr by ≥ 1.5 times of baseline within 1 week, based on Kidney Disease Improving Global Outcomes (KDIGO) guidelines. All patients aged ≥ 18 y/o admitted with confirmed SARS-COV-2 infection were included. Discrimination of variables was calculated by the Receiver Operator Characteristic Curve (ROC curve) utilizing area under curve. Some continuous variables were categorized through ROC curve. The cutoff points were calculated using the value with the best sensitivity and specificity. Results: A total of 1131 patients with COVID-19 admitted to the ICU were included. Patients mean age was 52 ± 15,8 y/o., with a prevalence of males 60% (n = 678). The risk of AKI was 33% (n = 376), 78% (n = 293) of which did not require dialysis. Overall mortality was 11% (n = 127), while for AKI patients, mortality rate was 21% (n = 80). Variables selected for the logistic regression model and inclusion in the final prognostic score were the following: age, diabetes, ACEis, ARBs, chronic kidney disease and hypertension. Conclusion: AKI development in COVID 19 patients is accurately predicted by common clinical variables, allowing early interventions to attenuate the impact of AKI in these patients.engBioMed CentralDevelopment of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Scoreinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCOVID-19COVID-19 PatientsCOV-AKI ScoreAcute Kidney Injury (AKI)info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/58976/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALve_Henrique_Palomba_etal_INI_2023.pdfve_Henrique_Palomba_etal_INI_2023.pdfapplication/pdf1003624https://www.arca.fiocruz.br/bitstream/icict/58976/2/ve_Henrique_Palomba_etal_INI_2023.pdff1c54a0505ca7ace2dcac6a8e14b50a4MD52icict/589762023-06-07 21:11:36.732oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-08T00:11:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.en_US.fl_str_mv Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
title Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
spellingShingle Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
Palomba, Henrique
COVID-19
COVID-19 Patients
COV-AKI Score
Acute Kidney Injury (AKI)
title_short Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
title_full Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
title_fullStr Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
title_full_unstemmed Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
title_sort Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score
author Palomba, Henrique
author_facet Palomba, Henrique
Cubos, Daniel
Bozza, Fernando
Zampieri, Fernando Godinho
Romano, Thiago Gomes
author_role author
author2 Cubos, Daniel
Bozza, Fernando
Zampieri, Fernando Godinho
Romano, Thiago Gomes
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Palomba, Henrique
Cubos, Daniel
Bozza, Fernando
Zampieri, Fernando Godinho
Romano, Thiago Gomes
dc.subject.en.en_US.fl_str_mv COVID-19
COVID-19 Patients
COV-AKI Score
Acute Kidney Injury (AKI)
topic COVID-19
COVID-19 Patients
COV-AKI Score
Acute Kidney Injury (AKI)
description Ethics approval and consent to participate The study was approved by the National Teaching and Ethical Committee (CONEP) in São Paulo / Brazil, number: 29496920.8.0000.5262 and informed consent was waived due to the observational nature of the study. The study was performed in accordance with the Declaration of Helsinki, the International Council for Harmonization and Good Clinical Practice.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-06-08T00:11:35Z
dc.date.available.fl_str_mv 2023-06-08T00:11:35Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PALOMBA, Henrique et al. Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score. BMC Nephrology, v. 24, n. 1, p. 1-8, Mar. 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/58976
dc.identifier.issn.en_US.fl_str_mv 1471-2369
dc.identifier.doi.none.fl_str_mv 10.1186/s12882-023-03095-4
dc.identifier.eissn.none.fl_str_mv 1471-2369
identifier_str_mv PALOMBA, Henrique et al. Development of a Risk Score for AKI onset in COVID-19 Patients: COV-AKI Score. BMC Nephrology, v. 24, n. 1, p. 1-8, Mar. 2023.
1471-2369
10.1186/s12882-023-03095-4
url https://www.arca.fiocruz.br/handle/icict/58976
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/58976/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/58976/2/ve_Henrique_Palomba_etal_INI_2023.pdf
bitstream.checksum.fl_str_mv 5a560609d32a3863062d77ff32785d58
f1c54a0505ca7ace2dcac6a8e14b50a4
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1822792144767680512

Registros relacionados