Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s11255-022-03454-4 http://hdl.handle.net/11449/248106 |
Resumo: | Introduction: Acute kidney injury (AKI) is one of the main complications of COVID-19 caused by SARS-CoV-2. This study aimed to evaluate the incidence of AKI in Brazilian hospitalized patients diagnosed with COVID-19 and identify the risk factors associated with its onset and those associated with its prognosis. Methods: A prospective cohort study of hospitalized patients diagnosed with COVID-19 at a public and tertiary university hospital in São Paulo from March to December 2020. Results: There were 347 patients hospitalized with COVID-19, 52.4% were admitted to the intensive care unit (ICU) and 47.6% were admitted to the wards. The overall incidence of AKI was 46.4%, more frequent in the ICU (68.1% vs 22.4, p < 0.01) and the overall mortality was 36.1%. Acute kidney replacement therapy was indicated in 46.6% of patients with AKI. In the general population, the factors associated with AKI were older age (OR 1.03, CI 1–1.05, p < 0.05), mechanical ventilation (OR 1.23, CI 1.06–1.83, p < 0.05), presence of proteinuria (OR 1.46, CI 1.22–1.93, p < 0.05), and use of vasoactive drugs (OR 1.26, CI 1.07–1.92, p < 0.05). Mortality was higher in the elderly (OR 1.08, CI 1.04–1.11, p < 0.05), in those with AKI (OR 1.12, CI 1.02–2.05, p < 0.05), particularly KDIGO stage 3 AKI (OR 1.10, CI 1.22–2.05, p < 0.05) and in need of mechanical ventilation (OR 1.13, CI 1.03–1.60, p < 0.05). Conclusion: AKI was frequent in hospitalized patients with COVID-19 and the factors associated with its development were older age, mechanical ventilation, use of vasoactive drugs, and presence of proteinuria, being a risk factor for death. |
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Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in BrazilAKICOVID-19Cross-talkIncidenceMortalityIntroduction: Acute kidney injury (AKI) is one of the main complications of COVID-19 caused by SARS-CoV-2. This study aimed to evaluate the incidence of AKI in Brazilian hospitalized patients diagnosed with COVID-19 and identify the risk factors associated with its onset and those associated with its prognosis. Methods: A prospective cohort study of hospitalized patients diagnosed with COVID-19 at a public and tertiary university hospital in São Paulo from March to December 2020. Results: There were 347 patients hospitalized with COVID-19, 52.4% were admitted to the intensive care unit (ICU) and 47.6% were admitted to the wards. The overall incidence of AKI was 46.4%, more frequent in the ICU (68.1% vs 22.4, p < 0.01) and the overall mortality was 36.1%. Acute kidney replacement therapy was indicated in 46.6% of patients with AKI. In the general population, the factors associated with AKI were older age (OR 1.03, CI 1–1.05, p < 0.05), mechanical ventilation (OR 1.23, CI 1.06–1.83, p < 0.05), presence of proteinuria (OR 1.46, CI 1.22–1.93, p < 0.05), and use of vasoactive drugs (OR 1.26, CI 1.07–1.92, p < 0.05). Mortality was higher in the elderly (OR 1.08, CI 1.04–1.11, p < 0.05), in those with AKI (OR 1.12, CI 1.02–2.05, p < 0.05), particularly KDIGO stage 3 AKI (OR 1.10, CI 1.22–2.05, p < 0.05) and in need of mechanical ventilation (OR 1.13, CI 1.03–1.60, p < 0.05). Conclusion: AKI was frequent in hospitalized patients with COVID-19 and the factors associated with its development were older age, mechanical ventilation, use of vasoactive drugs, and presence of proteinuria, being a risk factor for death.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)School of Medicine Faculdade de Medicina de Botucatu-UNESP, SPDepartamento de Clínica Médica Faculdade de Medicina de Botucatu-UNESP, SPSchool of Medicine Faculdade de Medicina de Botucatu-UNESP, SPDepartamento de Clínica Médica Faculdade de Medicina de Botucatu-UNESP, SPFAPESP: 2020/117668Universidade Estadual Paulista (UNESP)Magalhães, Luís Eduardo [UNESP]de Oliveira, Paula Gabriela Sousa [UNESP]Favarin, Ana Júlia [UNESP]Yuasa, Bruna Kaori [UNESP]Cardoso, Pedro Andriolo [UNESP]Zamoner, Welder [UNESP]Ponce, Daniela [UNESP]2023-07-29T13:34:37Z2023-07-29T13:34:37Z2023-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1501-1508http://dx.doi.org/10.1007/s11255-022-03454-4International Urology and Nephrology, v. 55, n. 6, p. 1501-1508, 2023.1573-25840301-1623http://hdl.handle.net/11449/24810610.1007/s11255-022-03454-42-s2.0-85145168975Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Urology and Nephrologyinfo:eu-repo/semantics/openAccess2024-08-14T17:21:55Zoai:repositorio.unesp.br:11449/248106Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:21:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
title |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
spellingShingle |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil Magalhães, Luís Eduardo [UNESP] AKI COVID-19 Cross-talk Incidence Mortality |
title_short |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
title_full |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
title_fullStr |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
title_full_unstemmed |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
title_sort |
Acute kidney injury in coronavirus infectious disease: a study of incidence, risk factors, and prognosis during the first wave of the disease in Brazil |
author |
Magalhães, Luís Eduardo [UNESP] |
author_facet |
Magalhães, Luís Eduardo [UNESP] de Oliveira, Paula Gabriela Sousa [UNESP] Favarin, Ana Júlia [UNESP] Yuasa, Bruna Kaori [UNESP] Cardoso, Pedro Andriolo [UNESP] Zamoner, Welder [UNESP] Ponce, Daniela [UNESP] |
author_role |
author |
author2 |
de Oliveira, Paula Gabriela Sousa [UNESP] Favarin, Ana Júlia [UNESP] Yuasa, Bruna Kaori [UNESP] Cardoso, Pedro Andriolo [UNESP] Zamoner, Welder [UNESP] Ponce, Daniela [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Magalhães, Luís Eduardo [UNESP] de Oliveira, Paula Gabriela Sousa [UNESP] Favarin, Ana Júlia [UNESP] Yuasa, Bruna Kaori [UNESP] Cardoso, Pedro Andriolo [UNESP] Zamoner, Welder [UNESP] Ponce, Daniela [UNESP] |
dc.subject.por.fl_str_mv |
AKI COVID-19 Cross-talk Incidence Mortality |
topic |
AKI COVID-19 Cross-talk Incidence Mortality |
description |
Introduction: Acute kidney injury (AKI) is one of the main complications of COVID-19 caused by SARS-CoV-2. This study aimed to evaluate the incidence of AKI in Brazilian hospitalized patients diagnosed with COVID-19 and identify the risk factors associated with its onset and those associated with its prognosis. Methods: A prospective cohort study of hospitalized patients diagnosed with COVID-19 at a public and tertiary university hospital in São Paulo from March to December 2020. Results: There were 347 patients hospitalized with COVID-19, 52.4% were admitted to the intensive care unit (ICU) and 47.6% were admitted to the wards. The overall incidence of AKI was 46.4%, more frequent in the ICU (68.1% vs 22.4, p < 0.01) and the overall mortality was 36.1%. Acute kidney replacement therapy was indicated in 46.6% of patients with AKI. In the general population, the factors associated with AKI were older age (OR 1.03, CI 1–1.05, p < 0.05), mechanical ventilation (OR 1.23, CI 1.06–1.83, p < 0.05), presence of proteinuria (OR 1.46, CI 1.22–1.93, p < 0.05), and use of vasoactive drugs (OR 1.26, CI 1.07–1.92, p < 0.05). Mortality was higher in the elderly (OR 1.08, CI 1.04–1.11, p < 0.05), in those with AKI (OR 1.12, CI 1.02–2.05, p < 0.05), particularly KDIGO stage 3 AKI (OR 1.10, CI 1.22–2.05, p < 0.05) and in need of mechanical ventilation (OR 1.13, CI 1.03–1.60, p < 0.05). Conclusion: AKI was frequent in hospitalized patients with COVID-19 and the factors associated with its development were older age, mechanical ventilation, use of vasoactive drugs, and presence of proteinuria, being a risk factor for death. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-07-29T13:34:37Z 2023-07-29T13:34:37Z 2023-06-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s11255-022-03454-4 International Urology and Nephrology, v. 55, n. 6, p. 1501-1508, 2023. 1573-2584 0301-1623 http://hdl.handle.net/11449/248106 10.1007/s11255-022-03454-4 2-s2.0-85145168975 |
url |
http://dx.doi.org/10.1007/s11255-022-03454-4 http://hdl.handle.net/11449/248106 |
identifier_str_mv |
International Urology and Nephrology, v. 55, n. 6, p. 1501-1508, 2023. 1573-2584 0301-1623 10.1007/s11255-022-03454-4 2-s2.0-85145168975 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Urology and Nephrology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1501-1508 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808128105465774080 |