The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods

Detalhes bibliográficos
Autor(a) principal: Bavinton, Benjamin R.
Data de Publicação: 2014
Outros Autores: Jin, Fengyi, Prestage, Garrett, Zablotska, Iryna, Koelsch, Kersten K., Phanuphak, Nittaya, Grinsztejn, Beatriz, Cooper, David A., Fairley, Christopher, Kelleher, Anthony, Triffitt, Kathy, Grulich, Andrew E.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11030
Resumo: National Health and Medical Research Council Project
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spelling Bavinton, Benjamin R.Jin, FengyiPrestage, GarrettZablotska, IrynaKoelsch, Kersten K.Phanuphak, NittayaGrinsztejn, BeatrizCooper, David A.Fairley, ChristopherKelleher, AnthonyTriffitt, KathyGrulich, Andrew E.2015-06-30T18:36:32Z2015-06-30T18:36:32Z2014BAVINTON, Benjamin R. et al. The opposites attract study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. BMC Infectious Diseases, v.14, n.917, p.1-8, 2014.1471-2334https://www.arca.fiocruz.br/handle/icict/1103010.1186/1471-2458-14-9171471-2334National Health and Medical Research Council ProjectUniversity of New South Wales. The Kirby Institute. Sydney, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, Australia / La Trobe University. Australian Research Centre in Sex. Health and Society. Melbourne, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, AustraliaThai Red Cross AIDS Research Centre. Bangkok, ThailandFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilUniversity of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, AustraliaMelbourne Sexual Health Centre. Victoria, Australia / Monash University. Victoria, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, Australia / St. Vincent’s Hospital. Sydney, Australia / St. Vincent’s Hospital. St. Vincent’s Centre for Applied Medical Research. Darlinghurst, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, AustraliaUniversity of New South Wales. The Kirby Institute. Sydney, AustraliaBackground: Studies in heterosexual HIV serodiscordant couples have provided critical evidence on the role of HIV treatments and undetectable viral load in reducing the risk of HIV transmission. There is very limited data on the risk of transmission from anal sex in homosexual male serodiscordant couples. Methods/Design: The Opposites Attract Study is an observational prospective longitudinal cohort study of male homosexual serodiscordant partnerships running from 2012 to 2015 and conducted in clinics throughout Australia, Brazil and Thailand. Couples attend two or more clinic visits per year. The HIV-positive partner’s viral load is tested and the HIV-negative partner is tested for HIV antibodies at every clinic visit. Results from any tests for sexually transmitted infections are also collected. Detailed behavioural questionnaires are completed by both partners at the time of each visit. The primary research question is whether HIV incidence is lower in those couples where the HIV-positive partner is receiving HIV treatment compared to couples where he is not receiving treatment. A voluntary semen sub-study will examine semen plasma viral load in a subsample of HIV-positive partners in Sydney, Rio de Janeiro and Bangkok. In cases of seroconversion of the initially HIV-negative partner, phylogenetic analysis will be conducted at the end of the study on virus from stored blood samples from both partners to determine if the infection came from the HIV-positive study partner. Men in new serodiscordant relationships will specifically be targeted for recruitment. Discussion: This study will provide critical data on the reduction in HIV transmission risk associated with being on HIV treatment in homosexual male serodiscordant couples in different regions of the world. Data from men in new relationships will be particularly valuable given that the highest transmission risk is in the first year of serodiscordant relationships. Furthermore, the detailed behavioural and attitudinal data from the participant questionnaires will allow exploration of many contextual factors associated with HIV risk, condom use and the negotiation of sexual practice within couples.engBioMed CentralThe opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methodsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIVHomosexualityAntiretroviral Therapy, Highly ActiveStatistical AnalysisHIVHomossexualidadeTerapia Antirretroviral de Alta AtividadeAnálise Estatísticainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82354https://www.arca.fiocruz.br/bitstream/icict/11030/1/license.txt8b4c200b4e10021c5683c6ccaba07169MD51ORIGINALThe Opposites Attract Study of viral load, HIV.pdfThe Opposites Attract Study of viral load, HIV.pdfapplication/pdf224838https://www.arca.fiocruz.br/bitstream/icict/11030/2/The%20Opposites%20Attract%20Study%20of%20viral%20load%2c%20HIV.pdf02f8e5d9560f9e2ca7b10be883dc3d46MD52TEXTThe Opposites Attract Study of viral load, HIV.pdf.txtThe Opposites Attract Study of viral load, HIV.pdf.txtExtracted texttext/plain40942https://www.arca.fiocruz.br/bitstream/icict/11030/3/The%20Opposites%20Attract%20Study%20of%20viral%20load%2c%20HIV.pdf.txt4d328cef57ad6fa9273a025b2ad99ebdMD53icict/110302023-06-15 16:17:16.735oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-06-15T19:17:16Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
title The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
spellingShingle The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
Bavinton, Benjamin R.
HIV
Homosexuality
Antiretroviral Therapy, Highly Active
Statistical Analysis
HIV
Homossexualidade
Terapia Antirretroviral de Alta Atividade
Análise Estatística
title_short The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
title_full The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
title_fullStr The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
title_full_unstemmed The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
title_sort The opposites attract study of viral load, hiv treatment and HIV transmission in serodiscordant homosexual male couples: design and methods
author Bavinton, Benjamin R.
author_facet Bavinton, Benjamin R.
Jin, Fengyi
Prestage, Garrett
Zablotska, Iryna
Koelsch, Kersten K.
Phanuphak, Nittaya
Grinsztejn, Beatriz
Cooper, David A.
Fairley, Christopher
Kelleher, Anthony
Triffitt, Kathy
Grulich, Andrew E.
author_role author
author2 Jin, Fengyi
Prestage, Garrett
Zablotska, Iryna
Koelsch, Kersten K.
Phanuphak, Nittaya
Grinsztejn, Beatriz
Cooper, David A.
Fairley, Christopher
Kelleher, Anthony
Triffitt, Kathy
Grulich, Andrew E.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bavinton, Benjamin R.
Jin, Fengyi
Prestage, Garrett
Zablotska, Iryna
Koelsch, Kersten K.
Phanuphak, Nittaya
Grinsztejn, Beatriz
Cooper, David A.
Fairley, Christopher
Kelleher, Anthony
Triffitt, Kathy
Grulich, Andrew E.
dc.subject.en.pt_BR.fl_str_mv HIV
Homosexuality
Antiretroviral Therapy, Highly Active
Statistical Analysis
topic HIV
Homosexuality
Antiretroviral Therapy, Highly Active
Statistical Analysis
HIV
Homossexualidade
Terapia Antirretroviral de Alta Atividade
Análise Estatística
dc.subject.decs.pt_BR.fl_str_mv HIV
Homossexualidade
Terapia Antirretroviral de Alta Atividade
Análise Estatística
description National Health and Medical Research Council Project
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-30T18:36:32Z
dc.date.available.fl_str_mv 2015-06-30T18:36:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BAVINTON, Benjamin R. et al. The opposites attract study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. BMC Infectious Diseases, v.14, n.917, p.1-8, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11030
dc.identifier.issn.none.fl_str_mv 1471-2334
dc.identifier.doi.none.fl_str_mv 10.1186/1471-2458-14-917
dc.identifier.eissn.none.fl_str_mv 1471-2334
identifier_str_mv BAVINTON, Benjamin R. et al. The opposites attract study of viral load, HIV treatment and HIV transmission in serodiscordant homosexual male couples: design and methods. BMC Infectious Diseases, v.14, n.917, p.1-8, 2014.
1471-2334
10.1186/1471-2458-14-917
url https://www.arca.fiocruz.br/handle/icict/11030
dc.language.iso.fl_str_mv eng
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dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
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