Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| DOI: | 10.2147/IDR.S135420 |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/20642 |
Resumo: | Program for Technological Development in Tools for Health (PDTIS), Fiocruz, the workers from LACENBA, LACEN-AC, and Fundação Hospitalar do Acre (Fundhacre). Funding support was provided by the National Counsel of Technological and Scientific Development (CNPq) process 478322/2012-7 and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) “Brasil sem Miséria” (BSM, Brazil without Misery) |
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Pacheco, Sidelcina RugieriSantos, Maria Isabel Magalhães Andrade dosStocker, AndreasZarife, Maria Alice Sant'AnnaSchinoni, Maria IsabelParaná, RaymundoReis, Mitermayer Galvão dosSilva, Luciano Kalabric2017-08-16T16:39:09Z2017-08-16T16:39:09Z2017PACHECO, S. R. et al. Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B. Infection and Drug Resistance, jul. 2017.1178-6973https://www.arca.fiocruz.br/handle/icict/2064210.2147/IDR.S135420Program for Technological Development in Tools for Health (PDTIS), Fiocruz, the workers from LACENBA, LACEN-AC, and Fundação Hospitalar do Acre (Fundhacre). Funding support was provided by the National Counsel of Technological and Scientific Development (CNPq) process 478322/2012-7 and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) “Brasil sem Miséria” (BSM, Brazil without Misery)Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilCentral Laboratory of Public Health of Bahia. Salvador, BA, BrazilUniversidade Federal da Bahia. Salvador, BA, BrasilUniversidade Federal da Bahia. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilResistance mutation analogs to nucleos(t)ides have been described in treatment-naïve patients with chronic hepatitis B (CHB), with clinical implications. The aim of this study was to investigate primary resistance mutations and genotypes circulating in patients naïve to chronic hepatitis B, in the Northern and Northeastern regions of Brazil. Methods: We conducted a study of resistance mutations and genotypic characterization of hepatitis B virus (HBV) in 189 treatment-naïve patients chronically infected with HBV. Results: Drug resistance-associated mutations located in the RT domain of the P gene (rtHBV) were found in 6% of the treatment-naïve patients from the Northeastern Region. The mutations were rtA194T, rtL180M + rtM204V, rtS202I, rtM204I, and rtA181S. No patient in the Northern Region had the resistance mutation. In the gene S region, the frequency of vaccine escape mutations was 2.4% in the Northeastern Region and 8.6% in the Northern Region. Conclusion: This information before the start of treatment may contribute to clinical decision making, reducing treatment failure and the risk of progression to cirrhosis and hepatocellular carcinoma for CHB.engDove Medical PressNordesteBrasilSequenciação diretaFalha de tratamentoNortheastBrazilDirect sequencingTreatment failureGenotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis Binfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/20642/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPacheco SR Genotyping of HBV....pdfPacheco SR Genotyping of 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| dc.title.pt_BR.fl_str_mv |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| title |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| spellingShingle |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B Pacheco, Sidelcina Rugieri Nordeste Brasil Sequenciação direta Falha de tratamento Northeast Brazil Direct sequencing Treatment failure |
| title_short |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| title_full |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| title_fullStr |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| title_full_unstemmed |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| title_sort |
Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B |
| author |
Pacheco, Sidelcina Rugieri |
| author_facet |
Pacheco, Sidelcina Rugieri Santos, Maria Isabel Magalhães Andrade dos Stocker, Andreas Zarife, Maria Alice Sant'Anna Schinoni, Maria Isabel Paraná, Raymundo Reis, Mitermayer Galvão dos Silva, Luciano Kalabric |
| author_role |
author |
| author2 |
Santos, Maria Isabel Magalhães Andrade dos Stocker, Andreas Zarife, Maria Alice Sant'Anna Schinoni, Maria Isabel Paraná, Raymundo Reis, Mitermayer Galvão dos Silva, Luciano Kalabric |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pacheco, Sidelcina Rugieri Santos, Maria Isabel Magalhães Andrade dos Stocker, Andreas Zarife, Maria Alice Sant'Anna Schinoni, Maria Isabel Paraná, Raymundo Reis, Mitermayer Galvão dos Silva, Luciano Kalabric |
| dc.subject.other.pt_BR.fl_str_mv |
Nordeste Brasil Sequenciação direta Falha de tratamento |
| topic |
Nordeste Brasil Sequenciação direta Falha de tratamento Northeast Brazil Direct sequencing Treatment failure |
| dc.subject.en.pt_BR.fl_str_mv |
Northeast Brazil Direct sequencing Treatment failure |
| description |
Program for Technological Development in Tools for Health (PDTIS), Fiocruz, the workers from LACENBA, LACEN-AC, and Fundação Hospitalar do Acre (Fundhacre). Funding support was provided by the National Counsel of Technological and Scientific Development (CNPq) process 478322/2012-7 and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) “Brasil sem Miséria” (BSM, Brazil without Misery) |
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2017 |
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2017-08-16T16:39:09Z |
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2017-08-16T16:39:09Z |
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2017 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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PACHECO, S. R. et al. Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B. Infection and Drug Resistance, jul. 2017. |
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https://www.arca.fiocruz.br/handle/icict/20642 |
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1178-6973 |
| dc.identifier.doi.none.fl_str_mv |
10.2147/IDR.S135420 |
| identifier_str_mv |
PACHECO, S. R. et al. Genotyping of HBV and tracking of resistance mutations in treatment-naïve patients with chronic hepatitis B. Infection and Drug Resistance, jul. 2017. 1178-6973 10.2147/IDR.S135420 |
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info:eu-repo/semantics/openAccess |
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Dove Medical Press |
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Dove Medical Press |
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