Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study

Detalhes bibliográficos
Autor(a) principal: Miranda, Ana Carolina de
Data de Publicação: 2023
Outros Autores: Stefani, Fernanda do Carmo de, Vesco, Bruna Cassia Dal, Carraro Júnior, Hipólito, Assreuy, Jamil, Morello, Luis Gustavo, Menezes, Igor Alexandre Cortês de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/60731
Resumo: Universidade Federal do Paraná. Hospital das Clínicas. Departamento de Medicina Interna. Curitiba, PR, Brasil.
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spelling Miranda, Ana Carolina deStefani, Fernanda do Carmo deVesco, Bruna Cassia DalCarraro Júnior, HipólitoAssreuy, JamilMorello, Luis GustavoMenezes, Igor Alexandre Cortês de2023-10-06T18:18:09Z2023-10-06T18:18:09Z2023MIRANDA, Ana Carolina de et al. Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study. Crit Care Sci. v. 35, n. 2, p. 177-186, 2023.https://www.arca.fiocruz.br/handle/icict/60731porAssociação de Medicina Intensiva Brasileira - AMIBRelationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Paraná. Hospital das Clínicas. Departamento de Medicina Interna. Curitiba, PR, Brasil.Universidade Federal do Paraná. Hospital das Clínicas. Unidade de Terapia Intensiva. Curitiba, PR.Universidade Federal do Paraná. Hospital das Clínicas. Unidade de Terapia Intensiva. Curitiba, PR.Universidade Federal do Paraná. Hospital das Clínicas. Unidade de Terapia Intensiva. Curitiba, PR.Universidade Federal de Santa Catarina. Departamento de Farmacologia. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Curitiba, PR, Brasil.Universidade Federal do Paraná. Hospital das Clínicas. Departamento de Medicina Interna. Curitiba, PR, Brasil.To measure the prognostic value of peripheral ischemic microvascular reserve in the context of persistent sepsis-induced hyperlactatemia and measure its influence on the temporal dynamics of lactate and the strength of association between these variables. Methods: This post hoc analysis of the peripheral perfusion index/postocclusive reactive hyperemia trial, an observational cohort study that enrolled patients with sepsis who persisted with lactate levels ≥ 2mmol/L after fluid resuscitation (with or without shock). Peripheral ischemic microvascular reserve was evaluated using the association of the peripheral perfusion index and postocclusive reactive hyperemia techniques. The cut off point of ∆ peripheral perfusion index peak values (%) defined the groups with low (≤ 62%) and high peripheral ischemic microvascular reserve (> 62%). Results: A total of 108 consecutive patients with persistent sepsis-induced hyperlactatemia were studied. The high peripheral ischemic microvascular reserve group showed higher 28-day mortality. than the low peripheral ischemic microvascular reserve group (p < 0.01). The temporal dynamics of lactate within the first 48 hours showed a rapid decrease in lactate levels in the low peripheral ischemic microvascular reserve group (p < 0.01). However, this result was not reproduced in the linear mixed effects model. A weak correlation between peripheral ischemic microvascular reserve (%) and lactate level (mmol/L) was observed within the first 24 hours (r = 0.23; p < 0.05). Conclusion: The prognostic value of high peripheral ischemic microvascular reserve was confirmed in the context of persistent sepsis-induced hyperlactatemia. Although there was a weak positive correlation between peripheral ischemic microvascular reserve value and lactate level within the first 24 hours of sepsis diagnosis, the low peripheral ischemic microvascular reserve group appeared to have a faster decrease in lactate over the 48 hours of follow-up.SepsisMicrocirculationHyperemiaPerfusion IndexLactatePrognosisSepsisMicrocirculaciónHiperemiaÍndice de PerfusiónPronósticoSepsieMicrocirculationIschémieHyperhémieIndice de perfusionPronosticSepseMicrocirculaçãoIsquemiaHiperemiaÍndice de PerfusãoLactatoPrognósticoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALccsci-35-02-0177.pdfccsci-35-02-0177.pdfapplication/pdf1055681https://www.arca.fiocruz.br/bitstream/icict/60731/2/ccsci-35-02-0177.pdff8faa8ddbaf5faec27298548557b8b63MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
title Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
spellingShingle Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
Miranda, Ana Carolina de
Sepsis
Microcirculation
Hyperemia
Perfusion Index
Lactate
Prognosis
Sepsis
Microcirculación
Hiperemia
Índice de Perfusión
Pronóstico
Sepsie
Microcirculation
Ischémie
Hyperhémie
Indice de perfusion
Pronostic
Sepse
Microcirculação
Isquemia
Hiperemia
Índice de Perfusão
Lactato
Prognóstico
title_short Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
title_full Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
title_fullStr Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
title_full_unstemmed Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
title_sort Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study
author Miranda, Ana Carolina de
author_facet Miranda, Ana Carolina de
Stefani, Fernanda do Carmo de
Vesco, Bruna Cassia Dal
Carraro Júnior, Hipólito
Assreuy, Jamil
Morello, Luis Gustavo
Menezes, Igor Alexandre Cortês de
author_role author
author2 Stefani, Fernanda do Carmo de
Vesco, Bruna Cassia Dal
Carraro Júnior, Hipólito
Assreuy, Jamil
Morello, Luis Gustavo
Menezes, Igor Alexandre Cortês de
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Miranda, Ana Carolina de
Stefani, Fernanda do Carmo de
Vesco, Bruna Cassia Dal
Carraro Júnior, Hipólito
Assreuy, Jamil
Morello, Luis Gustavo
Menezes, Igor Alexandre Cortês de
dc.subject.en.en_US.fl_str_mv Sepsis
Microcirculation
Hyperemia
Perfusion Index
Lactate
Prognosis
topic Sepsis
Microcirculation
Hyperemia
Perfusion Index
Lactate
Prognosis
Sepsis
Microcirculación
Hiperemia
Índice de Perfusión
Pronóstico
Sepsie
Microcirculation
Ischémie
Hyperhémie
Indice de perfusion
Pronostic
Sepse
Microcirculação
Isquemia
Hiperemia
Índice de Perfusão
Lactato
Prognóstico
dc.subject.es.en_US.fl_str_mv Sepsis
Microcirculación
Hiperemia
Índice de Perfusión
Pronóstico
dc.subject.fr.en_US.fl_str_mv Sepsie
Microcirculation
Ischémie
Hyperhémie
Indice de perfusion
Pronostic
dc.subject.decs.en_US.fl_str_mv Sepse
Microcirculação
Isquemia
Hiperemia
Índice de Perfusão
Lactato
Prognóstico
description Universidade Federal do Paraná. Hospital das Clínicas. Departamento de Medicina Interna. Curitiba, PR, Brasil.
publishDate 2023
dc.date.accessioned.fl_str_mv 2023-10-06T18:18:09Z
dc.date.available.fl_str_mv 2023-10-06T18:18:09Z
dc.date.issued.fl_str_mv 2023
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MIRANDA, Ana Carolina de et al. Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study. Crit Care Sci. v. 35, n. 2, p. 177-186, 2023.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/60731
identifier_str_mv MIRANDA, Ana Carolina de et al. Relationship between peripheral ischemic microvascular reserve, persistent hyperlactatemia, and its temporal dynamics in sepsis: a post hoc study. Crit Care Sci. v. 35, n. 2, p. 177-186, 2023.
url https://www.arca.fiocruz.br/handle/icict/60731
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação de Medicina Intensiva Brasileira - AMIB
publisher.none.fl_str_mv Associação de Medicina Intensiva Brasileira - AMIB
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/60731/2/ccsci-35-02-0177.pdf
https://www.arca.fiocruz.br/bitstream/icict/60731/1/license.txt
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repository.mail.fl_str_mv repositorio.arca@fiocruz.br
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