Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/35365 |
Resumo: | Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. |
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Corrêa, Raquel da SilvaRodrigues, Luciana SilvaPereira, Leticia Hagge LimaNogueira, Otto CastroLeung, JanaínaSousa, Marcela da S.Hacker, Mariana de AndreaSiqueira, Helio Ribeiro deCapone, DomênicoAlves, Rogério Lopes RufinoPessolani, Maria Cristina VidalSchmitz, VeronicaPereira, Geraldo Moura Batista2019-09-05T17:04:38Z2019-09-05T17:04:38Z2019CORRÊA, Raquel da Silva et al. Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-8, 2019.0074-0276https://www.arca.fiocruz.br/handle/icict/3536510.1590/0074-027601805791678-8060engFundação Oswaldo Cruz. Instituto Oswaldo CruzTuberculoseNeutrófilosCD64BiomarcadoresInfecção latente por tuberculoseTuberculosisBiomarkersNeutrophilsCD64Latent tuberculosis infectionNeutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Serviço de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Serviço de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Serviço de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Hospital Universitário Pedro Ernesto. Serviço de Pneumologia e Tisiologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.BACKGROUND CD64 (FcγR1) is a high-affinity receptor for monomeric IgG1 and IgG3. Circulating neutrophils express very low amounts of CD64 on their surface. OBJECTIVES Our primary aim was to investigate the utility of neutrophil CD64 surface expression as a biomarker of active pulmonary tuberculosis (TB). We hypothesised that elevated neutrophil CD64 expression in TB infection would be associated with interferon gamma (IFN-g) as an inducer of CD64 expression. METHODS The expression level of CD64 per neutrophil (PMN CD64 index) was quantitatively measured with flow cytometry using a Leuko64 kit in samples from patients with TB and latent TB infection (LTBI) as well as healthy controls, as part of a prospective cohort study in Brazil. FINDINGS The PMN CD64 index in patients with TB was higher than that in healthy controls and LTBI. Receiver operating characteristic curve analyses determined that the PMN CD64 index could discriminate patients with TB from those with LTBI and healthy individuals. PMN CD64 index levels returned to baseline levels after treatment. CONCLUSIONS T he p ositive r egulation o f C D64 e xpression i n c irculating n eutrophils o f p atients w ith a ctive T B c ould represent an additional biomarker for diagnosis of active TB and could be used for monitoring individuals with LTBI before progression of TB disease.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/35365/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALOttoNogueira_VeronicaSchmidt_etal_IOC_2019.pdfOttoNogueira_VeronicaSchmidt_etal_IOC_2019.pdfapplication/pdf1446910https://www.arca.fiocruz.br/bitstream/icict/35365/2/OttoNogueira_VeronicaSchmidt_etal_IOC_2019.pdfef033d0531670e4d42f32bc4c6409761MD52TEXTOttoNogueira_VeronicaSchmidt_etal_IOC_2019.pdf.txtOttoNogueira_VeronicaSchmidt_etal_IOC_2019.pdf.txtExtracted 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| dc.title.pt_BR.fl_str_mv |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| title |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| spellingShingle |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease Corrêa, Raquel da Silva Tuberculose Neutrófilos CD64 Biomarcadores Infecção latente por tuberculose Tuberculosis Biomarkers Neutrophils CD64 Latent tuberculosis infection |
| title_short |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| title_full |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| title_fullStr |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| title_full_unstemmed |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| title_sort |
Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease |
| author |
Corrêa, Raquel da Silva |
| author_facet |
Corrêa, Raquel da Silva Rodrigues, Luciana Silva Pereira, Leticia Hagge Lima Nogueira, Otto Castro Leung, Janaína Sousa, Marcela da S. Hacker, Mariana de Andrea Siqueira, Helio Ribeiro de Capone, Domênico Alves, Rogério Lopes Rufino Pessolani, Maria Cristina Vidal Schmitz, Veronica Pereira, Geraldo Moura Batista |
| author_role |
author |
| author2 |
Rodrigues, Luciana Silva Pereira, Leticia Hagge Lima Nogueira, Otto Castro Leung, Janaína Sousa, Marcela da S. Hacker, Mariana de Andrea Siqueira, Helio Ribeiro de Capone, Domênico Alves, Rogério Lopes Rufino Pessolani, Maria Cristina Vidal Schmitz, Veronica Pereira, Geraldo Moura Batista |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Corrêa, Raquel da Silva Rodrigues, Luciana Silva Pereira, Leticia Hagge Lima Nogueira, Otto Castro Leung, Janaína Sousa, Marcela da S. Hacker, Mariana de Andrea Siqueira, Helio Ribeiro de Capone, Domênico Alves, Rogério Lopes Rufino Pessolani, Maria Cristina Vidal Schmitz, Veronica Pereira, Geraldo Moura Batista |
| dc.subject.other.pt_BR.fl_str_mv |
Tuberculose Neutrófilos CD64 Biomarcadores Infecção latente por tuberculose |
| topic |
Tuberculose Neutrófilos CD64 Biomarcadores Infecção latente por tuberculose Tuberculosis Biomarkers Neutrophils CD64 Latent tuberculosis infection |
| dc.subject.en.pt_BR.fl_str_mv |
Tuberculosis Biomarkers Neutrophils CD64 Latent tuberculosis infection |
| description |
Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Laboratório de Imunopatologia. Rio de Janeiro, RJ, Brasil. |
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2019 |
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2019-09-05T17:04:38Z |
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2019-09-05T17:04:38Z |
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2019 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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CORRÊA, Raquel da Silva et al. Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-8, 2019. |
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https://www.arca.fiocruz.br/handle/icict/35365 |
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0074-0276 |
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10.1590/0074-02760180579 |
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1678-8060 |
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CORRÊA, Raquel da Silva et al. Neutrophil CD64 expression levels in IGRA-positive individuals distinguish latent tuberculosis from active disease. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 114, p. 1-8, 2019. 0074-0276 10.1590/0074-02760180579 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz |
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