Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31355 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil / Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil / Universidade Potiguar. Escola de Saúde. Natal, RN, Brasil. |
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Pereira, Nathalie de SenaQueiroga, Tamyres Bernadete DantasNunes, Daniela FerreiraAndrade, Cléber de MesquitaNascimento, Manuela Sales LimaMatta, Maria Adelaide do ValleCâmara, Antônia Cláudia Jácome daGalvão, Lúcia Maria da CunhaGuedes, Paulo Marcos MattaChiari, Egler2019-01-30T10:46:20Z2019-01-30T10:46:20Z2018PEREIRA, Nathalie de Sena; et al. Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients. PLoS Negl Trop Dis., v.12, n.7, e0006589, 21p, July 2018.1935-2727https://www.arca.fiocruz.br/handle/icict/313551935-2735engPublic Library of SciencePacientesCardiomiopatia Chagásica CrônicaDoença de ChagasDanos digestivosReceptores de Imunidade inataChronic chagasic cardiomyopathyInnate immune receptorsDigestive damagePatientsChagas diseaseInnate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil / Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil / Universidade Potiguar. Escola de Saúde. Natal, RN, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade do Estado do Rio Grande do Norte. Departamento de Ciências Biomédicas. Mossoró, RN, Brasil.Instituto Internacional de Neurociências Edmond e Lilly Safra. Macaíba, RN, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Ultraestrutura Celular. Rio de Janeiro, RJ. Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Análises Clínicas e Toxicológicas. Natal, RN, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil.Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil.Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrasilChronic chagasic cardiomyopathy (CCC) is observed in 30% to 50% of the individuals infected by Trypanosoma cruzi and heart failure is the important cause of death among patients in the chronic phase of Chagas disease. Although some studies have elucidated the role of adaptive immune responses involving T and B lymphocytes in cardiac pathogenesis, the role of innate immunity receptors such as Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in CCC pathophysiology has not yet been determined. In this study, we evaluated the association among innate immune receptors (TLR1-9 and nucleotide-binding domain-like receptor protein 3/NLRP3), its adapter molecules (Myd88, TRIF, ASC and caspase- 1) and cytokines (IL-1β, IL-6, IL-12, IL-18, IL-23, TNF-α, and IFN-β) with clinical manifestation, digestive and cardiac function in patients with different clinical forms of chronic Chagas disease. The TLR8 mRNA expression levels were enhanced in the peripheral blood mononuclear cells (PBMC) from digestive and cardiodigestive patients compared to indeterminate and cardiac patients. Furthermore, mRNA expression of IFN-β (cytokine produced after TLR8 activation) was higher in digestive and cardiodigestive patients when compared to indeterminate. Moreover, there was a positive correlation between TLR8 and IFN-β mRNA expression with sigmoid and rectum size. Cardiac and cardiodigestive patients presented higher TLR2, IL-12 and TNF-α mRNA expression than indeterminate and digestive patients. Moreover, cardiac patients also expressed higher levels of NLRP3, ASC and IL-1β mRNAs than indeterminate patients. In addition, we showed a negative correlation among TLR2, IL-1β, IL-12 and TNF-α levels with left ventricular ejection fraction, and positive correlation between NLRP3 with cardiothoracic index, and TLR2, IL-1β and IL-12 with left ventricular mass index. Together, our data suggest that high expression of innate immune.receptors in cardiac and digestive patients may induce an enhancement of cytokine expression and participate of cardiac and digestive dysfunction.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31355/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALadelaideV_Motta_etal_IOC_2018.pdfadelaideV_Motta_etal_IOC_2018.pdfapplication/pdf4348852https://www.arca.fiocruz.br/bitstream/icict/31355/2/adelaideV_Motta_etal_IOC_2018.pdf2a6663ea033f9812085adebf92dec5ceMD52TEXTadelaideV_Motta_etal_IOC_2018.pdf.txtadelaideV_Motta_etal_IOC_2018.pdf.txtExtracted texttext/plain67869https://www.arca.fiocruz.br/bitstream/icict/31355/3/adelaideV_Motta_etal_IOC_2018.pdf.txtb329396fd0f19d04f310b87130254427MD53icict/313552019-01-31 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dc.title.pt_BR.fl_str_mv |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
title |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
spellingShingle |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients Pereira, Nathalie de Sena Pacientes Cardiomiopatia Chagásica Crônica Doença de Chagas Danos digestivos Receptores de Imunidade inata Chronic chagasic cardiomyopathy Innate immune receptors Digestive damage Patients Chagas disease |
title_short |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
title_full |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
title_fullStr |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
title_full_unstemmed |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
title_sort |
Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients |
author |
Pereira, Nathalie de Sena |
author_facet |
Pereira, Nathalie de Sena Queiroga, Tamyres Bernadete Dantas Nunes, Daniela Ferreira Andrade, Cléber de Mesquita Nascimento, Manuela Sales Lima Matta, Maria Adelaide do Valle Câmara, Antônia Cláudia Jácome da Galvão, Lúcia Maria da Cunha Guedes, Paulo Marcos Matta Chiari, Egler |
author_role |
author |
author2 |
Queiroga, Tamyres Bernadete Dantas Nunes, Daniela Ferreira Andrade, Cléber de Mesquita Nascimento, Manuela Sales Lima Matta, Maria Adelaide do Valle Câmara, Antônia Cláudia Jácome da Galvão, Lúcia Maria da Cunha Guedes, Paulo Marcos Matta Chiari, Egler |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Pereira, Nathalie de Sena Queiroga, Tamyres Bernadete Dantas Nunes, Daniela Ferreira Andrade, Cléber de Mesquita Nascimento, Manuela Sales Lima Matta, Maria Adelaide do Valle Câmara, Antônia Cláudia Jácome da Galvão, Lúcia Maria da Cunha Guedes, Paulo Marcos Matta Chiari, Egler |
dc.subject.other.pt_BR.fl_str_mv |
Pacientes Cardiomiopatia Chagásica Crônica Doença de Chagas Danos digestivos Receptores de Imunidade inata |
topic |
Pacientes Cardiomiopatia Chagásica Crônica Doença de Chagas Danos digestivos Receptores de Imunidade inata Chronic chagasic cardiomyopathy Innate immune receptors Digestive damage Patients Chagas disease |
dc.subject.en.pt_BR.fl_str_mv |
Chronic chagasic cardiomyopathy Innate immune receptors Digestive damage Patients Chagas disease |
description |
Universidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, Brasil / Universidade Federal do Rio Grande do Norte. Departamento de Microbiologia e Parasitologia. Natal, RN, Brasil / Universidade Potiguar. Escola de Saúde. Natal, RN, Brasil. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2019-01-30T10:46:20Z |
dc.date.available.fl_str_mv |
2019-01-30T10:46:20Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PEREIRA, Nathalie de Sena; et al. Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients. PLoS Negl Trop Dis., v.12, n.7, e0006589, 21p, July 2018. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/31355 |
dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
dc.identifier.eissn.none.fl_str_mv |
1935-2735 |
identifier_str_mv |
PEREIRA, Nathalie de Sena; et al. Innate immune receptors over expression correlate with chronic chagasic cardiomyopathy and digestive damage in patients. PLoS Negl Trop Dis., v.12, n.7, e0006589, 21p, July 2018. 1935-2727 1935-2735 |
url |
https://www.arca.fiocruz.br/handle/icict/31355 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Public Library of Science |
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Public Library of Science |
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Repositório Institucional da FIOCRUZ (ARCA) |
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