SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/49831 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay. |
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Tort, Luis Fernando LopezRibeiro, Ieda PereiraMenezes, Lidiane Souza RaphaelSantos, Alexandre Araújo Cunha dosSantos, Marta PereiraDamasceno, LuanaSilva, Paola Cristina ResendeSiqueira, Marilda Agudo Mendonça Teixeira deBrasil, PatriciaBonaldo, Myrna Cristina2021-11-14T12:53:21Z2021-11-14T12:53:21Z2021TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021.0074-0206https://www.arca.fiocruz.br/handle/icict/4983110.1590/0074-027602101661678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.SARS-CoV-2COVID-19Variantes de interesseLinhagem N.9E484KRio de JaneiroBrasilSARS-CoV-2COVID-19Variants of interestLineage N.9E484KRio de JaneiroBrazilSARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.BACKGROUND The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.33-derived lineage named N.9 was described recently in Brazil and it’s considered a potential variant of interest (VOI) due to the presence of E484K substitution at the receptor-binding domain (RBD) of the Spike (S) protein. OBJECTIVE To describe the first detection of variant N.9 in Rio de Janeiro State. METHODS SARS-CoV-2 N.9 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR), wholegenome sequencing and phylogenetic analysis. FINDINGS Here, we report two SARS-CoV-2 N.9 lineage strains in Rio de Janeiro. One of them had only the E484K substitution of the six N.9 lineage-defining mutations. Other three strains pre-defined as N.9 have the same genomic profile. These four strains are grouped within the B.1.1.33 lineage and basal to the N.9 lineage in our phylogenetic analysis, and we call them “N.9- like/B.1.1.33 + E484K”. MAIN CONCLUSIONS The phylogenetic analysis shows four independent introductions of N.9 in the state of Rio de Janeiro in October and December 2020, January and March 2021. SARS-CoV-2 N.9 dissemination in the Rio de Janeiro could have been limited by the emergence and dominance of other variants, mainly by the lineage P.2 VOI Zeta that emerged in the same period and co-circulated with N.9, as observed in the neighboring State of São Paulo.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49831/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarilda Siqueira_PaolaSIlva_etal_IOC_2021.pdfMarilda Siqueira_PaolaSIlva_etal_IOC_2021.pdfapplication/pdf2187254https://www.arca.fiocruz.br/bitstream/icict/49831/2/Marilda%20Siqueira_PaolaSIlva_etal_IOC_2021.pdf3f553ae36dcc365650e10e748e79aec7MD52icict/498312021-11-14 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| dc.title.pt_BR.fl_str_mv |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| title |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| spellingShingle |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil Tort, Luis Fernando Lopez SARS-CoV-2 COVID-19 Variantes de interesse Linhagem N.9 E484K Rio de Janeiro Brasil SARS-CoV-2 COVID-19 Variants of interest Lineage N.9 E484K Rio de Janeiro Brazil |
| title_short |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| title_full |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| title_fullStr |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| title_full_unstemmed |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| title_sort |
SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil |
| author |
Tort, Luis Fernando Lopez |
| author_facet |
Tort, Luis Fernando Lopez Ribeiro, Ieda Pereira Menezes, Lidiane Souza Raphael Santos, Alexandre Araújo Cunha dos Santos, Marta Pereira Damasceno, Luana Silva, Paola Cristina Resende Siqueira, Marilda Agudo Mendonça Teixeira de Brasil, Patricia Bonaldo, Myrna Cristina |
| author_role |
author |
| author2 |
Ribeiro, Ieda Pereira Menezes, Lidiane Souza Raphael Santos, Alexandre Araújo Cunha dos Santos, Marta Pereira Damasceno, Luana Silva, Paola Cristina Resende Siqueira, Marilda Agudo Mendonça Teixeira de Brasil, Patricia Bonaldo, Myrna Cristina |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Tort, Luis Fernando Lopez Ribeiro, Ieda Pereira Menezes, Lidiane Souza Raphael Santos, Alexandre Araújo Cunha dos Santos, Marta Pereira Damasceno, Luana Silva, Paola Cristina Resende Siqueira, Marilda Agudo Mendonça Teixeira de Brasil, Patricia Bonaldo, Myrna Cristina |
| dc.subject.other.pt_BR.fl_str_mv |
SARS-CoV-2 COVID-19 Variantes de interesse Linhagem N.9 E484K Rio de Janeiro Brasil |
| topic |
SARS-CoV-2 COVID-19 Variantes de interesse Linhagem N.9 E484K Rio de Janeiro Brasil SARS-CoV-2 COVID-19 Variants of interest Lineage N.9 E484K Rio de Janeiro Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
SARS-CoV-2 COVID-19 Variants of interest Lineage N.9 E484K Rio de Janeiro Brazil |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay. |
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2021 |
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2021-11-14T12:53:21Z |
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2021-11-14T12:53:21Z |
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2021 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021. |
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https://www.arca.fiocruz.br/handle/icict/49831 |
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0074-0206 |
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10.1590/0074-02760210166 |
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1678-8060 |
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TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021. 0074-0206 10.1590/0074-02760210166 1678-8060 |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. |
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