SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Tort, Luis Fernando Lopez
Data de Publicação: 2021
Outros Autores: Ribeiro, Ieda Pereira, Menezes, Lidiane Souza Raphael, Santos, Alexandre Araújo Cunha dos, Santos, Marta Pereira, Damasceno, Luana, Silva, Paola Cristina Resende, Siqueira, Marilda Agudo Mendonça Teixeira de, Brasil, Patricia, Bonaldo, Myrna Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/49831
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
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spelling Tort, Luis Fernando LopezRibeiro, Ieda PereiraMenezes, Lidiane Souza RaphaelSantos, Alexandre Araújo Cunha dosSantos, Marta PereiraDamasceno, LuanaSilva, Paola Cristina ResendeSiqueira, Marilda Agudo Mendonça Teixeira deBrasil, PatriciaBonaldo, Myrna Cristina2021-11-14T12:53:21Z2021-11-14T12:53:21Z2021TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021.0074-0206https://www.arca.fiocruz.br/handle/icict/4983110.1590/0074-027602101661678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.SARS-CoV-2COVID-19Variantes de interesseLinhagem N.9E484KRio de JaneiroBrasilSARS-CoV-2COVID-19Variants of interestLineage N.9E484KRio de JaneiroBrazilSARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.BACKGROUND The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.33-derived lineage named N.9 was described recently in Brazil and it’s considered a potential variant of interest (VOI) due to the presence of E484K substitution at the receptor-binding domain (RBD) of the Spike (S) protein. OBJECTIVE To describe the first detection of variant N.9 in Rio de Janeiro State. METHODS SARS-CoV-2 N.9 was confirmed by quantitative reverse transcription polymerase chain reaction (qRT-PCR), wholegenome sequencing and phylogenetic analysis. FINDINGS Here, we report two SARS-CoV-2 N.9 lineage strains in Rio de Janeiro. One of them had only the E484K substitution of the six N.9 lineage-defining mutations. Other three strains pre-defined as N.9 have the same genomic profile. These four strains are grouped within the B.1.1.33 lineage and basal to the N.9 lineage in our phylogenetic analysis, and we call them “N.9- like/B.1.1.33 + E484K”. MAIN CONCLUSIONS The phylogenetic analysis shows four independent introductions of N.9 in the state of Rio de Janeiro in October and December 2020, January and March 2021. SARS-CoV-2 N.9 dissemination in the Rio de Janeiro could have been limited by the emergence and dominance of other variants, mainly by the lineage P.2 VOI Zeta that emerged in the same period and co-circulated with N.9, as observed in the neighboring State of São Paulo.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/49831/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALMarilda Siqueira_PaolaSIlva_etal_IOC_2021.pdfMarilda Siqueira_PaolaSIlva_etal_IOC_2021.pdfapplication/pdf2187254https://www.arca.fiocruz.br/bitstream/icict/49831/2/Marilda%20Siqueira_PaolaSIlva_etal_IOC_2021.pdf3f553ae36dcc365650e10e748e79aec7MD52icict/498312021-11-14 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dc.title.pt_BR.fl_str_mv SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
title SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
spellingShingle SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
Tort, Luis Fernando Lopez
SARS-CoV-2
COVID-19
Variantes de interesse
Linhagem N.9
E484K
Rio de Janeiro
Brasil
SARS-CoV-2
COVID-19
Variants of interest
Lineage N.9
E484K
Rio de Janeiro
Brazil
title_short SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
title_full SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
title_fullStr SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
title_full_unstemmed SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
title_sort SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil
author Tort, Luis Fernando Lopez
author_facet Tort, Luis Fernando Lopez
Ribeiro, Ieda Pereira
Menezes, Lidiane Souza Raphael
Santos, Alexandre Araújo Cunha dos
Santos, Marta Pereira
Damasceno, Luana
Silva, Paola Cristina Resende
Siqueira, Marilda Agudo Mendonça Teixeira de
Brasil, Patricia
Bonaldo, Myrna Cristina
author_role author
author2 Ribeiro, Ieda Pereira
Menezes, Lidiane Souza Raphael
Santos, Alexandre Araújo Cunha dos
Santos, Marta Pereira
Damasceno, Luana
Silva, Paola Cristina Resende
Siqueira, Marilda Agudo Mendonça Teixeira de
Brasil, Patricia
Bonaldo, Myrna Cristina
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tort, Luis Fernando Lopez
Ribeiro, Ieda Pereira
Menezes, Lidiane Souza Raphael
Santos, Alexandre Araújo Cunha dos
Santos, Marta Pereira
Damasceno, Luana
Silva, Paola Cristina Resende
Siqueira, Marilda Agudo Mendonça Teixeira de
Brasil, Patricia
Bonaldo, Myrna Cristina
dc.subject.other.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
Variantes de interesse
Linhagem N.9
E484K
Rio de Janeiro
Brasil
topic SARS-CoV-2
COVID-19
Variantes de interesse
Linhagem N.9
E484K
Rio de Janeiro
Brasil
SARS-CoV-2
COVID-19
Variants of interest
Lineage N.9
E484K
Rio de Janeiro
Brazil
dc.subject.en.pt_BR.fl_str_mv SARS-CoV-2
COVID-19
Variants of interest
Lineage N.9
E484K
Rio de Janeiro
Brazil
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil / Universidad de la República. Centro Universitario Regional Litoral Norte. Laboratorio de Virología Molecular. Salto, Uruguay.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-11-14T12:53:21Z
dc.date.available.fl_str_mv 2021-11-14T12:53:21Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/49831
dc.identifier.issn.pt_BR.fl_str_mv 0074-0206
dc.identifier.doi.none.fl_str_mv 10.1590/0074-02760210166
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv TORT, Luis Fernando Lopez et al. SARS-CoV-2 variant N.9 identified in Rio de Janeiro, Brazil. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 116, e210166, p. 1-4, 2021.
0074-0206
10.1590/0074-02760210166
1678-8060
url https://www.arca.fiocruz.br/handle/icict/49831
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
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