Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.

Detalhes bibliográficos
Autor(a) principal: Andrade, Marcus Vinicius Melo de
Data de Publicação: 2011
Outros Autores: Iwaki, Shoko, Ropert, Catherine Maryvette, Gazzinelli, Ricardo Tostes, Melo, Jose Renan da Cunha, Beaven, Michael Antony
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/8103
Resumo: National Institutes of Health. National Heart, Lung, and Blood Institute. Laboratory of Molecular Immunology. Bethesda, MD, USA/Universidade Federal de Minas Gerais. Escola de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brazil
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spelling Andrade, Marcus Vinicius Melo deIwaki, ShokoRopert, Catherine MaryvetteGazzinelli, Ricardo TostesMelo, Jose Renan da CunhaBeaven, Michael Antony2014-07-31T12:50:33Z2014-07-31T12:50:33Z2011ANDRADE, Marcus Vinicius Melo de et al. Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33. Eur J Immunol., 41(3): 760-772,2011.0014-2980https://www.arca.fiocruz.br/handle/icict/8103engVerlag Chemie GmbH.Antigens/administration & dosageCytokines/biosynthesisMast Cells/metabolismMyeloid Differentiation Factor 88/deficiencyAmplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNational Institutes of Health. National Heart, Lung, and Blood Institute. Laboratory of Molecular Immunology. Bethesda, MD, USA/Universidade Federal de Minas Gerais. Escola de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, BrazilNational Institutes of Health. National Heart, Lung, and Blood Institute. Laboratory of Molecular Immunology. Bethesda, MD, USAFundação Oswaldo Cruz. Centro de Pesquisas Rene ́Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas Rene ́Rachou. Laboratório de Imunopatologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Escola de Medicina. Departamento de Enfermagem. Belo Horizonte, MG, BrazilNational Institutes of Health. National Heart, Lung, and Blood Institute. Laboratory of Molecular Immunology. Bethesda, MD, USAL-33 is associated with atopic and autoimmune diseases and, as reported here, it interacts synergistically with Ag to markedly enhance production of inflammatory cytokines in rodent mast cells even in the absence of degranulation. Investigation of the underlying mechanisms revealed that synergy in signaling occurred at the level of TGF-β-activated kinase 1, which was then transmitted downstream through JNK, p38 MAP kinase, and AP-1. Stimulation of the Ca(2+) /calcineurin/NFAT pathway by Ag, which IL-33 did not, was critical for the synergy between Ag and IL-33. For example, selective stimulation of the NFAT pathway by thapsigargin also markedly enhanced responses to IL-33 in a calcineurin-dependent manner. As indicated by luciferase-reporter assays, IL-33 failed to stimulate the transcriptional activities of NFAT and AP-1 but augmented the activation of these transcription factors by Ag or thapsigargin. Robust stimulation of NF-κB transcriptional activity by IL-33 was also essential for the synergy. These and pharmacologic data suggested that the enhanced production of cytokines resulted in part from amplification of the activation of AP-1 and NFAT as well as co-operative interactions among transcription factors. IL-33 may retune mast cell responses to Ag toward enhanced cytokine production and thus determine the symptoms and severity of Ag-dependent allergic and autoimmune diseases.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAmplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.pdfAmplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.pdfapplication/pdf3336885https://www.arca.fiocruz.br/bitstream/icict/8103/1/Amplification%20of%20cytokine%20production%20through%20synergistic%20activation%20of%20NFAT%20and%20AP-1%20following%20stimulation%20of%20mast%20cells%20with%20antigen%20and%20IL-33.pdfa989827a69a92122d37dfa68bfd4d32aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8103/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTAmplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.pdf.txtAmplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.pdf.txtExtracted texttext/plain13https://www.arca.fiocruz.br/bitstream/icict/8103/3/Amplification%20of%20cytokine%20production%20through%20synergistic%20activation%20of%20NFAT%20and%20AP-1%20following%20stimulation%20of%20mast%20cells%20with%20antigen%20and%20IL-33.pdf.txt67e866c735744ec6037b77b623ee022dMD53icict/81032018-04-06 08:48:47.272oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:48:47Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
title Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
spellingShingle Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
Andrade, Marcus Vinicius Melo de
Antigens/administration & dosage
Cytokines/biosynthesis
Mast Cells/metabolism
Myeloid Differentiation Factor 88/deficiency
title_short Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
title_full Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
title_fullStr Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
title_full_unstemmed Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
title_sort Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33.
author Andrade, Marcus Vinicius Melo de
author_facet Andrade, Marcus Vinicius Melo de
Iwaki, Shoko
Ropert, Catherine Maryvette
Gazzinelli, Ricardo Tostes
Melo, Jose Renan da Cunha
Beaven, Michael Antony
author_role author
author2 Iwaki, Shoko
Ropert, Catherine Maryvette
Gazzinelli, Ricardo Tostes
Melo, Jose Renan da Cunha
Beaven, Michael Antony
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Andrade, Marcus Vinicius Melo de
Iwaki, Shoko
Ropert, Catherine Maryvette
Gazzinelli, Ricardo Tostes
Melo, Jose Renan da Cunha
Beaven, Michael Antony
dc.subject.other.pt_BR.fl_str_mv Antigens/administration & dosage
Cytokines/biosynthesis
Mast Cells/metabolism
Myeloid Differentiation Factor 88/deficiency
topic Antigens/administration & dosage
Cytokines/biosynthesis
Mast Cells/metabolism
Myeloid Differentiation Factor 88/deficiency
description National Institutes of Health. National Heart, Lung, and Blood Institute. Laboratory of Molecular Immunology. Bethesda, MD, USA/Universidade Federal de Minas Gerais. Escola de Medicina. Departamento de Medicina Interna. Belo Horizonte, MG, Brazil
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2014-07-31T12:50:33Z
dc.date.available.fl_str_mv 2014-07-31T12:50:33Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Marcus Vinicius Melo de et al. Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33. Eur J Immunol., 41(3): 760-772,2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/8103
dc.identifier.issn.none.fl_str_mv 0014-2980
identifier_str_mv ANDRADE, Marcus Vinicius Melo de et al. Amplification of cytokine production through synergistic activation of NFAT and AP-1 following stimulation of mast cells with antigen and IL-33. Eur J Immunol., 41(3): 760-772,2011.
0014-2980
url https://www.arca.fiocruz.br/handle/icict/8103
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Verlag Chemie GmbH.
publisher.none.fl_str_mv Verlag Chemie GmbH.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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