Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25529 |
Resumo: | U-MDT Leprosy clinical trial ± Brazil was funded by the Department of Science and Technology (DECIT) of Brazilian Ministry of Health and the Brazilian Council for Research (CNPq process #403293/2005-7) |
| id |
CRUZ_ff6e543481b906bfd5998f55e07ee6ab |
|---|---|
| oai_identifier_str |
oai:www.arca.fiocruz.br:icict/25529 |
| network_acronym_str |
CRUZ |
| network_name_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| repository_id_str |
2135 |
| spelling |
Penna, Gerson OliveiraBührer-Sékula, SamiraKerr, Lígia Regina SansigoloStefani, Mariane Martins de AraújoRodrigues, Laura CunhaAraújo, Marcelo Grossi deRamos, Andrea Machado CoelhoAndrade, Ana Regina Coelho deCosta, Maurício BarcelosRosa, Patricia SammarcoGonçalves, Heitor de SáCruz, RossileneBarreto, Maurício LimaPontes, Maria Araci de AndradePenna, Maria Lúcia Fernandes2018-03-27T17:01:58Z2018-03-27T17:01:58Z2017PENNA, G. O. et al. Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients. PLoS Neglected Tropical Diseases, v. 11, n. 7, p. e0005725, 2017.1935-2727https://www.arca.fiocruz.br/handle/icict/2552910.1371/journal.pntd.0005725U-MDT Leprosy clinical trial ± Brazil was funded by the Department of Science and Technology (DECIT) of Brazilian Ministry of Health and the Brazilian Council for Research (CNPq process #403293/2005-7)University of Brasília. Tropical Medicine Centre. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Brasília, DF, BrasilFederal University of Goiás. Tropical Pathology and Public Health Institute. Goiânia, GO, BrazilFederal University of Ceará. Department of Public Health. Fortaleza, CE, BrazilFederal University of Goiás. Tropical Pathology and Public Health Institute. Goiânia, GO, BrazilLondon School of Hygiene and Tropical Medicine. Department of Infectious and Tropical Diseases.London EnglandFederal University of Minas Gerais. Clinical Hospital. Dermatology Department. Belo Horizonte, MG, BraziFederal University of Minas Gerais. Clinical Hospital. Dermatology Department. Belo Horizonte, MG, BraziFederal University of Minas Gerais. Clinical Hospital. Dermatology Department. Belo Horizonte, MG, BraziFederal University of Goiás. Medicine Faculty. Goiania, GO, BrazilLauro de Souza Lima Institute, Bauru, SP, BrazilDona Libania Dermatology Centre. Fortaleza, CE, BrazilTropical Dermatology and Venerology Alfredo da Matta Foundation. Manaus, AM, BrazilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, BrasilDona Libania Dermatology Centre. Fortaleza, CE, BrazilFederal University Fluminense. Epidemiology and Biostatistics Department. Niteroi, RJ, BrazilLeprosy control is based on early diagnosis and multidrug therapy. For treatment purposes, leprosy patients can be classified as paucibacillary (PB) or multibacillary (MB), according to the number of skin lesions. Studies regarding a uniform treatment regimen (U-MDT) for all leprosy patients have been encouraged by the WHO, rendering disease classification unnecessary.engPublic Library of ScienceHanseníase MultibacilarFatores de TempoDiagnóstico precoceTuberculose resistente a drogasResultado do tratamentoHumanosBrasilLeprosy, MultibacillaryTime FactorsEarly diagnosisDrug Resistant TuberculosisTreatment OutcomeHumansBrazilUniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25529/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALPenna GO Uniform multidrug therapy for leprosy....pdfPenna GO Uniform multidrug therapy for leprosy....pdfapplication/pdf4808381https://www.arca.fiocruz.br/bitstream/icict/25529/2/Penna%20GO%20Uniform%20multidrug%20therapy%20for%20leprosy....pdf2a0d3c844f1146b106bd3c2c66d2fd68MD52TEXTPenna GO Uniform multidrug therapy for leprosy....pdf.txtPenna GO Uniform multidrug therapy for leprosy....pdf.txtExtracted texttext/plain53225https://www.arca.fiocruz.br/bitstream/icict/25529/3/Penna%20GO%20Uniform%20multidrug%20therapy%20for%20leprosy....pdf.txt3a8ca3cf84ba1bab122c82cef49374c2MD53icict/255292023-03-15 14:33:56.99oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:56Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| title |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| spellingShingle |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients Penna, Gerson Oliveira Hanseníase Multibacilar Fatores de Tempo Diagnóstico precoce Tuberculose resistente a drogas Resultado do tratamento Humanos Brasil Leprosy, Multibacillary Time Factors Early diagnosis Drug Resistant Tuberculosis Treatment Outcome Humans Brazil |
| title_short |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| title_full |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| title_fullStr |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| title_full_unstemmed |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| title_sort |
Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients |
| author |
Penna, Gerson Oliveira |
| author_facet |
Penna, Gerson Oliveira Bührer-Sékula, Samira Kerr, Lígia Regina Sansigolo Stefani, Mariane Martins de Araújo Rodrigues, Laura Cunha Araújo, Marcelo Grossi de Ramos, Andrea Machado Coelho Andrade, Ana Regina Coelho de Costa, Maurício Barcelos Rosa, Patricia Sammarco Gonçalves, Heitor de Sá Cruz, Rossilene Barreto, Maurício Lima Pontes, Maria Araci de Andrade Penna, Maria Lúcia Fernandes |
| author_role |
author |
| author2 |
Bührer-Sékula, Samira Kerr, Lígia Regina Sansigolo Stefani, Mariane Martins de Araújo Rodrigues, Laura Cunha Araújo, Marcelo Grossi de Ramos, Andrea Machado Coelho Andrade, Ana Regina Coelho de Costa, Maurício Barcelos Rosa, Patricia Sammarco Gonçalves, Heitor de Sá Cruz, Rossilene Barreto, Maurício Lima Pontes, Maria Araci de Andrade Penna, Maria Lúcia Fernandes |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Penna, Gerson Oliveira Bührer-Sékula, Samira Kerr, Lígia Regina Sansigolo Stefani, Mariane Martins de Araújo Rodrigues, Laura Cunha Araújo, Marcelo Grossi de Ramos, Andrea Machado Coelho Andrade, Ana Regina Coelho de Costa, Maurício Barcelos Rosa, Patricia Sammarco Gonçalves, Heitor de Sá Cruz, Rossilene Barreto, Maurício Lima Pontes, Maria Araci de Andrade Penna, Maria Lúcia Fernandes |
| dc.subject.other.pt_BR.fl_str_mv |
Hanseníase Multibacilar Fatores de Tempo Diagnóstico precoce Tuberculose resistente a drogas Resultado do tratamento Humanos Brasil |
| topic |
Hanseníase Multibacilar Fatores de Tempo Diagnóstico precoce Tuberculose resistente a drogas Resultado do tratamento Humanos Brasil Leprosy, Multibacillary Time Factors Early diagnosis Drug Resistant Tuberculosis Treatment Outcome Humans Brazil |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy, Multibacillary Time Factors Early diagnosis Drug Resistant Tuberculosis Treatment Outcome Humans Brazil |
| description |
U-MDT Leprosy clinical trial ± Brazil was funded by the Department of Science and Technology (DECIT) of Brazilian Ministry of Health and the Brazilian Council for Research (CNPq process #403293/2005-7) |
| publishDate |
2017 |
| dc.date.issued.fl_str_mv |
2017 |
| dc.date.accessioned.fl_str_mv |
2018-03-27T17:01:58Z |
| dc.date.available.fl_str_mv |
2018-03-27T17:01:58Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.citation.fl_str_mv |
PENNA, G. O. et al. Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients. PLoS Neglected Tropical Diseases, v. 11, n. 7, p. e0005725, 2017. |
| dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/25529 |
| dc.identifier.issn.pt_BR.fl_str_mv |
1935-2727 |
| dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pntd.0005725 |
| identifier_str_mv |
PENNA, G. O. et al. Uniform multidrug therapy for leprosy patients in Brazil (U-MDT/CT-BR): Results of an open label, randomized and controlled clinical trial, among multibacillary patients. PLoS Neglected Tropical Diseases, v. 11, n. 7, p. e0005725, 2017. 1935-2727 10.1371/journal.pntd.0005725 |
| url |
https://www.arca.fiocruz.br/handle/icict/25529 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.publisher.none.fl_str_mv |
Public Library of Science |
| publisher.none.fl_str_mv |
Public Library of Science |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
| instacron_str |
FIOCRUZ |
| institution |
FIOCRUZ |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| bitstream.url.fl_str_mv |
https://www.arca.fiocruz.br/bitstream/icict/25529/1/license.txt https://www.arca.fiocruz.br/bitstream/icict/25529/2/Penna%20GO%20Uniform%20multidrug%20therapy%20for%20leprosy....pdf https://www.arca.fiocruz.br/bitstream/icict/25529/3/Penna%20GO%20Uniform%20multidrug%20therapy%20for%20leprosy....pdf.txt |
| bitstream.checksum.fl_str_mv |
5a560609d32a3863062d77ff32785d58 2a0d3c844f1146b106bd3c2c66d2fd68 3a8ca3cf84ba1bab122c82cef49374c2 |
| bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
| repository.name.fl_str_mv |
Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ) |
| repository.mail.fl_str_mv |
repositorio.arca@fiocruz.br |
| _version_ |
1813009013069053952 |